G11 -
mGlu3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.2
PAE mean: 25.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | H8 | V | 835 | 8x51 | G.hns1 | A | 36 | G.hns1.01 |
Van-der-waals | H8 | V | 835 | 8x51 | G.hns1 | A | 36 | G.hns1.01 |
Polar | H8 | H | 837 | 8x53 | G.h2s4 | N | 222 | G.h2s4.03 |
Ionic | H8 | R | 838 | 8x54 | G.HN | D | 32 | G.HN.50 |
Polar | H8 | R | 838 | 8x54 | G.HN | D | 32 | G.HN.50 |
Hydrophobic | H8 | R | 838 | 8x54 | G.HN | D | 32 | G.HN.50 |
Van-der-waals | H8 | R | 838 | 8x54 | G.HN | D | 32 | G.HN.50 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | N | 357 | G.H5.24 |
Ionic | ICL2 | R | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | ICL2 | R | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | ICL2 | R | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | TM6 | A | 768 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | A | 768 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL2 | V | 673 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | H8 | V | 835 | 8x51 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | H8 | V | 835 | 8x51 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | H8 | V | 834 | 8x50 | G.HN | K | 33 | G.HN.51 |
Van-der-waals | H8 | V | 834 | 8x50 | G.HN | K | 33 | G.HN.51 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL1 | K | 608 | 12x51 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | K | 608 | 12x51 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL3 | P | 762 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | P | 762 | - | G.H5 | K | 354 | G.H5.21 |
Polar | H8 | H | 837 | 8x53 | G.HN | K | 33 | G.HN.51 |
Hydrophobic | H8 | H | 837 | 8x53 | G.HN | K | 33 | G.HN.51 |
Van-der-waals | H8 | H | 837 | 8x53 | G.HN | K | 33 | G.HN.51 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL3 | C | 761 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL3 | C | 761 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL3 | C | 761 | - | G.H5 | V | 359 | G.H5.26 |
Polar | ICL3 | N | 764 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | L | 353 | G.H5.20 |
Polar | ICL3 | N | 764 | - | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | N | 357 | G.H5.24 |
Polar | ICL1 | P | 605 | 12x48 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | P | 605 | 12x48 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | P | 605 | 12x48 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL2 | V | 673 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM3 | I | 666 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 666 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL3 | F | 765 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | V | 835 | 8x51 | G.HN | K | 33 | G.HN.51 |
Van-der-waals | H8 | V | 835 | 8x51 | G.HN | K | 33 | G.HN.51 |
Hydrophobic | H8 | H | 837 | 8x53 | G.HN | L | 29 | G.HN.47 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | N | 352 | G.H5.19 |
Polar | ICL1 | N | 603 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | N | 603 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | L | 606 | 12x49 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | N | 764 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | P | 762 | - | G.H5 | L | 351 | G.H5.18 |
Polar | ICL2 | R | 679 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 679 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 679 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Polar | ICL3 | E | 763 | - | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL3 | E | 763 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | TM3 | I | 666 | 3x54 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM3 | I | 666 | 3x54 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL1 | S | 610 | 12x53 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | E | 767 | 6x35 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | L | 353 | G.H5.20 |
Polar | ICL1 | T | 604 | 12x47 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | T | 604 | 12x47 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | T | 604 | 12x47 | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM3 | F | 670 | 3x58 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM5 | T | 758 | 5x61 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM5 | T | 758 | 5x61 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL3 | N | 764 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | K | 354 | G.H5.21 |
Polar | TM6 | E | 767 | 6x35 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | E | 767 | 6x35 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | E | 767 | 6x35 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | N | 766 | - | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL3 | N | 766 | - | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL3 | N | 766 | - | G.H5 | N | 357 | G.H5.24 |
Polar | ICL3 | K | 760 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | K | 760 | - | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL3 | K | 760 | - | G.H5 | K | 354 | G.H5.21 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | T | 836 | 8x52 | G.h2s4 | N | 222 | G.h2s4.03 |
Hydrophobic | H8 | L | 839 | 8x55 | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | H8 | L | 839 | 8x55 | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | C | 761 | - | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | ICL3 | C | 761 | - | G.H5 | K | 354 | G.H5.21 |
Polar | H8 | T | 836 | 8x52 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | A | 768 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Polar | TM6 | A | 768 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | A | 768 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | K | 662 | 3x50 | G.H5 | L | 358 | G.H5.25 |