G13 -
mGlu3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 24.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 871 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | V | 871 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | C-term | S | 878 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 878 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | C-term | S | 878 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | S | 878 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | S | 878 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Polar | ICL2 | A | 677 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | A | 677 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | A | 677 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | L | 879 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | L | 879 | - | H.HA | L | 106 | H.HA.29 |
Polar | H8 | R | 838 | 8x54 | G.hns1 | V | 45 | G.hns1.01 |
Van-der-waals | H8 | R | 838 | 8x54 | G.hns1 | V | 45 | G.hns1.01 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | K | 372 | G.H5.21 |
Polar | H8 | R | 838 | 8x54 | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL2 | V | 673 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | R | 679 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | R | 679 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL1 | K | 608 | 12x51 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL1 | K | 608 | 12x51 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | E | 870 | - | G.H2 | R | 227 | G.H2.01 |
Van-der-waals | C-term | E | 870 | - | G.H2 | R | 227 | G.H2.01 |
Polar | ICL1 | A | 609 | 12x52 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | Q | 377 | G.H5.26 |
Polar | C-term | E | 870 | - | G.H2 | S | 228 | G.H2.02 |
Hydrophobic | C-term | E | 870 | - | G.H2 | S | 228 | G.H2.02 |
Van-der-waals | C-term | E | 870 | - | G.H2 | S | 228 | G.H2.02 |
Polar | ICL2 | N | 675 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | N | 675 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | N | 675 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | ICL2 | R | 679 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | R | 679 | - | G.HN | T | 43 | G.HN.52 |
Hydrophobic | ICL2 | A | 677 | - | G.S2 | I | 213 | G.S2.08 |
Van-der-waals | ICL2 | A | 677 | - | G.S2 | I | 213 | G.S2.08 |
Hydrophobic | C-term | L | 879 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 879 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | T | 875 | - | H.HB | T | 127 | H.HB.14 |
Van-der-waals | C-term | T | 875 | - | H.HB | T | 127 | H.HB.14 |
Hydrophobic | C-term | T | 876 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | V | 865 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | V | 865 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | S | 877 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | S | 877 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | S | 877 | - | H.HA | V | 98 | H.HA.21 |
Polar | ICL1 | L | 606 | 12x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL1 | L | 606 | 12x49 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | L | 606 | 12x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | S | 878 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | C-term | S | 877 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | S | 877 | - | H.HA | A | 102 | H.HA.25 |
Van-der-waals | C-term | S | 877 | - | H.HA | A | 102 | H.HA.25 |
Polar | ICL2 | A | 677 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | A | 677 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | A | 677 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | C-term | S | 874 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | S | 874 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | D | 873 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | ICL2 | V | 673 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | T | 875 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | ICL3 | C | 761 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | C | 761 | - | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | L | 879 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | L | 879 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | L | 879 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Polar | H8 | T | 836 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | H8 | T | 836 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | H8 | T | 836 | 8x52 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | ICL3 | E | 763 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL3 | N | 764 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | C-term | E | 870 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | C-term | L | 872 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | L | 872 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | TM3 | I | 666 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | I | 666 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | Q | 678 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | Q | 678 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | Q | 678 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | C-term | C | 866 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | C | 866 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | L | 872 | - | G.s3h2 | Q | 226 | G.s3h2.03 |
Van-der-waals | C-term | L | 872 | - | G.s3h2 | Q | 226 | G.s3h2.03 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | R | 679 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Polar | ICL3 | P | 762 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | P | 762 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | P | 762 | - | G.H5 | H | 368 | G.H5.17 |
Polar | ICL2 | Q | 678 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | Q | 678 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Van-der-waals | ICL2 | Q | 678 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | ICL2 | G | 676 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | G | 676 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Aromatic | TM3 | F | 670 | 3x58 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | C-term | T | 875 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | V | 835 | 8x51 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | E | 767 | 6x35 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | E | 767 | 6x35 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | L | 879 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | L | 879 | - | H.HD | E | 167 | H.HD.12 |
Polar | C-term | T | 875 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | H8 | L | 839 | 8x55 | G.H3 | V | 280 | G.H3.17 |
Hydrophobic | ICL2 | A | 677 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | L | 879 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | ICL2 | K | 674 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 674 | - | G.s2s3 | K | 214 | G.s2s3.01 |
Polar | C-term | S | 877 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | S | 877 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | S | 877 | - | H.HA | D | 101 | H.HA.24 |
Aromatic | ICL3 | F | 765 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | P | 762 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ICL3 | P | 762 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ICL3 | P | 762 | - | G.H5 | K | 372 | G.H5.21 |
Polar | ICL2 | A | 677 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | A | 677 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | A | 677 | - | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | S | 877 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | S | 877 | - | H.HA | K | 105 | H.HA.28 |
Polar | H8 | R | 838 | 8x54 | G.h2s4 | S | 239 | G.h2s4.03 |
Hydrophobic | H8 | R | 838 | 8x54 | G.h2s4 | S | 239 | G.h2s4.03 |
Van-der-waals | H8 | R | 838 | 8x54 | G.h2s4 | S | 239 | G.h2s4.03 |
Hydrophobic | C-term | T | 876 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | T | 876 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | ICL1 | P | 605 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | P | 605 | 12x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | L | 841 | 8x57 | G.h2s4 | D | 238 | G.h2s4.02 |
Van-der-waals | H8 | L | 841 | 8x57 | G.h2s4 | D | 238 | G.h2s4.02 |
Hydrophobic | C-term | S | 877 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | ICL1 | P | 605 | 12x48 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | S | 874 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | S | 874 | - | G.s4h3 | M | 257 | G.s4h3.09 |