Gi1 -
mGlu3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 22.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | V | 673 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | V | 673 | - | G.hns1 | R | 32 | G.hns1.03 |
Ionic | ICL2 | K | 674 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | K | 674 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 674 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 674 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | N | 675 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | N | 675 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | N | 675 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | C-term | T | 860 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | C-term | T | 860 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | T | 860 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | H8 | T | 836 | 8x52 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | N | 675 | - | G.HN | K | 29 | G.HN.53 |
Van-der-waals | ICL2 | N | 675 | - | G.HN | K | 29 | G.HN.53 |
Polar | ICL2 | K | 674 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | K | 674 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 674 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | I | 666 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | A | 677 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | ICL2 | A | 677 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL2 | A | 677 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | G | 676 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | G | 676 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 676 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM4 | Q | 688 | 4x32 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM4 | Q | 688 | 4x32 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL1 | K | 608 | 12x51 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | ICL1 | K | 608 | 12x51 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | A | 677 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | A | 677 | - | G.S1 | E | 33 | G.S1.01 |
Polar | ICL2 | K | 674 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | G | 676 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | G | 676 | - | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | G | 676 | - | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | G | 672 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 672 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | H8 | L | 839 | 8x55 | G.H5 | V | 342 | G.H5.14 |
Polar | ICL2 | Q | 678 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | ICL2 | Q | 678 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL2 | Q | 678 | - | G.hns1 | A | 30 | G.hns1.01 |
Hydrophobic | H8 | V | 835 | 8x51 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | H8 | V | 835 | 8x51 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | C-term | V | 846 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | H8 | L | 839 | 8x55 | G.H5 | A | 338 | G.H5.10 |
Polar | C-term | T | 860 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | C-term | T | 860 | - | H.HA | E | 65 | H.HA.03 |
Van-der-waals | C-term | T | 860 | - | H.HA | E | 65 | H.HA.03 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | E | 767 | 6x35 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | I | 666 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 666 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | P | 762 | - | G.H5 | I | 344 | G.H5.16 |
Polar | TM2 | G | 611 | 2x35 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM2 | G | 611 | 2x35 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | G | 611 | 2x35 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | I | 683 | - | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | I | 683 | - | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | H | 837 | 8x53 | G.S6 | Y | 320 | G.S6.02 |
Aromatic | H8 | H | 837 | 8x53 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | H8 | H | 837 | 8x53 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | H8 | H | 837 | 8x53 | G.S6 | Y | 320 | G.S6.02 |
Ionic | H8 | H | 837 | 8x53 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | H8 | H | 837 | 8x53 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | H8 | H | 837 | 8x53 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | H8 | H | 837 | 8x53 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 862 | - | H.HA | Q | 68 | H.HA.06 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL2 | R | 679 | - | G.H5 | D | 350 | G.H5.22 |
Polar | ICL2 | R | 679 | - | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | R | 679 | - | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | R | 679 | - | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | P | 762 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | P | 762 | - | G.H5 | D | 341 | G.H5.13 |
Ionic | C-term | E | 870 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Polar | C-term | E | 870 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | C-term | E | 870 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Van-der-waals | C-term | E | 870 | - | G.hfs2 | K | 180 | G.hfs2.04 |
Hydrophobic | ICL2 | I | 683 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | I | 683 | - | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | C | 665 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | C | 665 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | C | 665 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | H8 | L | 839 | 8x55 | G.S6 | H | 322 | G.S6.04 |
Van-der-waals | H8 | L | 839 | 8x55 | G.S6 | H | 322 | G.S6.04 |
Hydrophobic | ICL2 | G | 676 | - | G.hns1 | A | 30 | G.hns1.01 |
Van-der-waals | ICL2 | G | 676 | - | G.hns1 | A | 30 | G.hns1.01 |
Polar | ICL2 | V | 673 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | V | 673 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | V | 673 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM4 | P | 685 | 4x29 | G.H5 | C | 351 | G.H5.23 |
Aromatic | C-term | F | 844 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | C-term | F | 844 | - | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | C-term | F | 844 | - | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | G | 676 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | G | 676 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | G | 676 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | G | 676 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | G | 676 | - | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | K | 674 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | H8 | H | 837 | 8x53 | G.H5 | K | 349 | G.H5.21 |
Polar | ICL3 | N | 764 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | G | 672 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | G | 672 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | G | 672 | - | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL2 | A | 677 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | TM2 | G | 611 | 2x35 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM2 | G | 611 | 2x35 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | K | 662 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | V | 865 | - | H.HA | V | 72 | H.HA.10 |
Hydrophobic | ICL2 | N | 675 | - | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | N | 675 | - | G.HN | E | 28 | G.HN.52 |
Polar | TM4 | S | 684 | 4x28 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | P | 680 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | V | 673 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 673 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | G | 676 | - | G.HN | K | 29 | G.HN.53 |
Van-der-waals | ICL2 | G | 676 | - | G.HN | K | 29 | G.HN.53 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Polar | ICL2 | N | 675 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 675 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | N | 675 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | K | 345 | G.H5.17 |
Polar | ICL1 | K | 608 | 12x51 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | ICL1 | K | 608 | 12x51 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL1 | K | 608 | 12x51 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM4 | P | 685 | 4x29 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | V | 835 | 8x51 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | V | 835 | 8x51 | G.H5 | F | 354 | G.H5.26 |
Polar | ICL1 | K | 608 | 12x51 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL1 | K | 608 | 12x51 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL1 | S | 610 | 12x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL1 | S | 610 | 12x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | F | 354 | G.H5.26 |