Golf -
mGlu3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.2
PAE mean: 25.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM4 | S | 684 | 4x28 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | I | 666 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | I | 666 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Ionic | ICL3 | E | 763 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Polar | ICL3 | E | 763 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Van-der-waals | ICL3 | E | 763 | - | G.s2s3 | K | 203 | G.s2s3.02 |
Hydrophobic | C-term | F | 844 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Van-der-waals | C-term | F | 844 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | ICL3 | C | 761 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | H8 | H | 837 | 8x53 | G.H5 | I | 369 | G.H5.14 |
Van-der-waals | H8 | H | 837 | 8x53 | G.H5 | I | 369 | G.H5.14 |
Hydrophobic | H8 | H | 840 | 8x56 | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | H8 | H | 840 | 8x56 | G.hgh4 | D | 310 | G.hgh4.13 |
Aromatic | TM3 | F | 670 | 3x58 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | I | 683 | - | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | N | 675 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL2 | N | 675 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL2 | N | 675 | - | G.HN | R | 36 | G.HN.51 |
Polar | ICL2 | V | 673 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | ICL2 | V | 673 | - | G.hns1 | Y | 39 | G.hns1.01 |
Van-der-waals | ICL2 | V | 673 | - | G.hns1 | Y | 39 | G.hns1.01 |
Hydrophobic | ICL3 | P | 762 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL3 | P | 762 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | R | 372 | G.H5.17 |
Polar | TM3 | A | 667 | 3x55 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM3 | A | 667 | 3x55 | G.hns1 | K | 40 | G.hns1.02 |
Ionic | ICL2 | D | 671 | - | G.HN | R | 36 | G.HN.51 |
Polar | ICL2 | D | 671 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL2 | D | 671 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL2 | D | 671 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL3 | P | 762 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | A | 677 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Van-der-waals | ICL2 | A | 677 | - | G.h2s4 | N | 226 | G.h2s4.02 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | K | 760 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | K | 674 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | K | 674 | - | G.hns1 | K | 40 | G.hns1.02 |
Ionic | ICL2 | R | 679 | - | G.H5 | E | 379 | G.H5.24 |
Polar | ICL2 | R | 679 | - | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | R | 679 | - | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL2 | R | 679 | - | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | H8 | H | 837 | 8x53 | G.S6 | Y | 347 | G.S6.02 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | R | 679 | - | G.h3s5 | T | 271 | G.h3s5.02 |
Hydrophobic | ICL2 | K | 674 | - | G.HN | L | 37 | G.HN.52 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | Y | 378 | G.H5.23 |
Polar | TM3 | C | 665 | 3x53 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | C | 665 | 3x53 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM3 | C | 665 | 3x53 | G.H5 | E | 379 | G.H5.24 |
Polar | C-term | F | 844 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | F | 844 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | F | 844 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | ICL3 | N | 764 | - | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | Q | 371 | G.H5.16 |
Ionic | C-term | R | 843 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Polar | C-term | R | 843 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | C-term | R | 843 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Van-der-waals | C-term | R | 843 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Hydrophobic | C-term | R | 843 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | F | 844 | - | G.hgh4 | E | 309 | G.hgh4.12 |
Polar | ICL2 | P | 680 | - | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL2 | P | 680 | - | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 673 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | ICL2 | V | 673 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | ICL3 | F | 765 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | F | 765 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | F | 844 | - | G.hgh4 | V | 307 | G.hgh4.10 |
Van-der-waals | C-term | F | 844 | - | G.hgh4 | V | 307 | G.hgh4.10 |
Hydrophobic | H8 | L | 839 | 8x55 | G.hgh4 | T | 312 | G.hgh4.15 |
Van-der-waals | H8 | L | 839 | 8x55 | G.hgh4 | T | 312 | G.hgh4.15 |
Hydrophobic | ICL2 | K | 674 | - | G.hns1 | Y | 39 | G.hns1.01 |
Polar | ICL2 | A | 677 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | ICL2 | A | 677 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Ionic | ICL2 | D | 671 | - | G.hns1 | K | 40 | G.hns1.02 |
Polar | ICL2 | D | 671 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL2 | D | 671 | - | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | D | 671 | - | G.hns1 | K | 40 | G.hns1.02 |
Aromatic | H8 | H | 837 | 8x53 | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | H8 | H | 837 | 8x53 | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | H8 | H | 837 | 8x53 | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | C-term | F | 844 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | C-term | F | 844 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Van-der-waals | C-term | F | 844 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Ionic | H8 | H | 837 | 8x53 | G.H5 | D | 365 | G.H5.10 |
Polar | H8 | H | 837 | 8x53 | G.H5 | D | 365 | G.H5.10 |
Hydrophobic | H8 | H | 837 | 8x53 | G.H5 | D | 365 | G.H5.10 |
Van-der-waals | H8 | H | 837 | 8x53 | G.H5 | D | 365 | G.H5.10 |
Hydrophobic | TM3 | I | 669 | 3x57 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM3 | I | 669 | 3x57 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 673 | - | G.hns1 | K | 40 | G.hns1.02 |
Hydrophobic | ICL1 | A | 609 | 12x52 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | ICL1 | A | 609 | 12x52 | G.H5 | L | 381 | G.H5.26 |
Polar | ICL2 | K | 674 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL2 | K | 674 | - | G.HN | R | 36 | G.HN.51 |
Van-der-waals | ICL2 | K | 674 | - | G.HN | R | 36 | G.HN.51 |
Hydrophobic | ICL3 | N | 764 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | N | 764 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | H8 | L | 841 | 8x57 | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | H8 | L | 841 | 8x57 | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | TM3 | C | 665 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | C | 665 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | F | 670 | 3x58 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | F | 670 | 3x58 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | G | 676 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Hydrophobic | ICL2 | G | 676 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Van-der-waals | ICL2 | G | 676 | - | G.h2s4 | D | 227 | G.h2s4.03 |
Polar | H8 | V | 834 | 8x50 | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL2 | V | 673 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | V | 673 | - | G.H5 | Y | 378 | G.H5.23 |
Polar | TM4 | Q | 688 | 4x32 | G.H5 | E | 379 | G.H5.24 |