G12 -
mGlu4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 20.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | N | 909 | - | G.hfs2 | A | 207 | G.hfs2.04 |
Polar | C-term | G | 883 | - | G.S2 | D | 215 | G.S2.05 |
Hydrophobic | C-term | G | 883 | - | G.S2 | D | 215 | G.S2.05 |
Van-der-waals | C-term | G | 883 | - | G.S2 | D | 215 | G.S2.05 |
Hydrophobic | C-term | Y | 907 | - | H.HE | V | 179 | H.HE.02 |
Van-der-waals | C-term | Y | 907 | - | H.HE | V | 179 | H.HE.02 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | T | 903 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | T | 903 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | T | 903 | - | H.HA | K | 114 | H.HA.28 |
Polar | H8 | R | 858 | 8x55 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | Y | 907 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | Y | 907 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | T | 908 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | T | 908 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Ionic | H8 | R | 858 | 8x55 | G.H5 | D | 377 | G.H5.22 |
Polar | H8 | R | 858 | 8x55 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | H8 | R | 858 | 8x55 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | Y | 907 | - | H.HA | V | 107 | H.HA.21 |
Polar | C-term | N | 882 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | C-term | N | 882 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | N | 882 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | ICL2 | V | 688 | - | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | V | 688 | - | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | G | 684 | 3x61 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | R | 686 | 3x63 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | TM3 | R | 686 | 3x63 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | C-term | N | 882 | - | G.S2 | F | 216 | G.S2.06 |
Van-der-waals | C-term | N | 882 | - | G.S2 | F | 216 | G.S2.06 |
Polar | C-term | C | 890 | - | G.H2 | K | 237 | G.H2.06 |
Hydrophobic | C-term | C | 890 | - | G.H2 | K | 237 | G.H2.06 |
Van-der-waals | C-term | C | 890 | - | G.H2 | K | 237 | G.H2.06 |
Aromatic | C-term | Y | 904 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | Y | 904 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | Y | 904 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | S | 887 | - | G.S2 | V | 212 | G.S2.02 |
Hydrophobic | C-term | Y | 904 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | Y | 904 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | ICL2 | V | 688 | - | G.S1 | V | 58 | G.S1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | C-term | T | 906 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | C-term | K | 886 | - | G.S2 | V | 212 | G.S2.02 |
Van-der-waals | C-term | K | 886 | - | G.S2 | V | 212 | G.S2.02 |
Hydrophobic | TM3 | F | 681 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | S | 687 | 3x64 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | TM3 | S | 687 | 3x64 | G.S3 | I | 221 | G.S3.01 |
Polar | ICL3 | T | 780 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | ICL3 | T | 780 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | T | 780 | - | G.H5 | K | 376 | G.H5.21 |
Polar | H8 | R | 858 | 8x55 | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | H8 | R | 858 | 8x55 | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | H8 | R | 858 | 8x55 | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | TM3 | G | 684 | 3x61 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | V | 905 | - | H.HB | M | 132 | H.HB.10 |
Hydrophobic | TM3 | K | 685 | 3x62 | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | C | 890 | - | G.H2 | Q | 240 | G.H2.09 |
Hydrophobic | C-term | C | 890 | - | G.H2 | Q | 240 | G.H2.09 |
Van-der-waals | C-term | C | 890 | - | G.H2 | Q | 240 | G.H2.09 |
Polar | C-term | L | 893 | - | G.H2 | K | 237 | G.H2.06 |
Hydrophobic | C-term | L | 893 | - | G.H2 | K | 237 | G.H2.06 |
Hydrophobic | C-term | Y | 904 | - | H.HA | A | 111 | H.HA.25 |
Hydrophobic | ICL2 | S | 689 | - | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | A | 866 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | C-term | A | 866 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 677 | 3x54 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | G | 883 | - | G.H1 | R | 78 | G.H1.09 |
Hydrophobic | C-term | A | 885 | - | G.S2 | V | 212 | G.S2.02 |
Van-der-waals | C-term | A | 885 | - | G.S2 | V | 212 | G.S2.02 |
Polar | C-term | E | 884 | - | G.S2 | D | 215 | G.S2.05 |
Hydrophobic | C-term | T | 906 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Van-der-waals | C-term | T | 906 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Polar | C-term | N | 909 | - | H.HA | D | 99 | H.HA.13 |
Van-der-waals | C-term | N | 909 | - | H.HA | D | 99 | H.HA.13 |
Hydrophobic | C-term | Y | 904 | - | H.hdhe | F | 173 | H.hdhe.01 |
Polar | C-term | V | 905 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | V | 905 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | V | 905 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | V | 688 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | V | 688 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | G | 883 | - | G.S2 | F | 216 | G.S2.06 |
Van-der-waals | C-term | G | 883 | - | G.S2 | F | 216 | G.S2.06 |
Polar | ICL2 | S | 689 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | S | 689 | - | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | S | 689 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | V | 688 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | Y | 907 | - | H.hdhe | L | 175 | H.hdhe.03 |
Polar | C-term | E | 888 | - | G.S2 | I | 211 | G.S2.01 |
Van-der-waals | C-term | E | 888 | - | G.S2 | I | 211 | G.S2.01 |
Hydrophobic | ICL3 | P | 778 | - | G.H5 | Q | 372 | G.H5.17 |
Polar | C-term | K | 886 | - | G.S2 | E | 213 | G.S2.03 |
Van-der-waals | C-term | K | 886 | - | G.S2 | E | 213 | G.S2.03 |
Polar | TM3 | R | 676 | 3x53 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | R | 676 | 3x53 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | A | 690 | - | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | G | 883 | - | G.S2 | H | 214 | G.S2.04 |
Hydrophobic | C-term | V | 905 | - | H.HA | R | 106 | H.HA.20 |
Hydrophobic | C-term | Y | 907 | - | H.HA | G | 104 | H.HA.18 |
Van-der-waals | C-term | Y | 907 | - | H.HA | G | 104 | H.HA.18 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | V | 863 | - | G.h2s4 | G | 244 | G.h2s4.03 |
Polar | ICL2 | S | 689 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | S | 689 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | S | 689 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | H8 | R | 858 | 8x55 | G.h2s4 | T | 246 | G.h2s4.05 |
Van-der-waals | H8 | R | 858 | 8x55 | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | C-term | P | 881 | - | G.h1ha | R | 83 | G.h1ha.02 |
Polar | C-term | N | 909 | - | H.HA | K | 103 | H.HA.17 |
Hydrophobic | C-term | N | 909 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | N | 909 | - | H.HA | K | 103 | H.HA.17 |
Polar | C-term | H | 910 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | C-term | H | 910 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Van-der-waals | C-term | H | 910 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Polar | H8 | R | 856 | 8x53 | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | H8 | R | 856 | 8x53 | G.h3s5 | N | 288 | G.h3s5.02 |
Polar | C-term | N | 882 | - | G.H1 | H | 81 | G.H1.12 |
Van-der-waals | C-term | N | 882 | - | G.H1 | H | 81 | G.H1.12 |
Polar | C-term | Y | 907 | - | H.HA | N | 100 | H.HA.14 |
Hydrophobic | C-term | Y | 907 | - | H.HA | N | 100 | H.HA.14 |
Van-der-waals | C-term | Y | 907 | - | H.HA | N | 100 | H.HA.14 |
Polar | H8 | K | 857 | 8x54 | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | H8 | K | 857 | 8x54 | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | H8 | K | 857 | 8x54 | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | C-term | N | 882 | - | G.h1ha | G | 82 | G.h1ha.01 |
Van-der-waals | C-term | N | 882 | - | G.h1ha | G | 82 | G.h1ha.01 |
Polar | C-term | N | 882 | - | G.S2 | V | 217 | G.S2.07 |
Hydrophobic | C-term | N | 882 | - | G.S2 | V | 217 | G.S2.07 |
Van-der-waals | C-term | N | 882 | - | G.S2 | V | 217 | G.S2.07 |
Hydrophobic | C-term | Y | 907 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Van-der-waals | C-term | Y | 907 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Polar | C-term | Q | 902 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | Q | 902 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | Q | 902 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | Y | 907 | - | H.hdhe | G | 176 | H.hdhe.04 |
Van-der-waals | C-term | Y | 907 | - | H.hdhe | G | 176 | H.hdhe.04 |
Hydrophobic | H8 | R | 858 | 8x55 | G.h3s5 | V | 289 | G.h3s5.03 |
Van-der-waals | H8 | R | 858 | 8x55 | G.h3s5 | V | 289 | G.h3s5.03 |
Aromatic | H8 | R | 856 | 8x53 | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | H8 | R | 856 | 8x53 | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | ICL2 | R | 692 | - | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | R | 692 | - | G.HN | R | 52 | G.HN.52 |
Hydrophobic | C-term | V | 905 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | V | 905 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | I | 680 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | A | 885 | - | G.S2 | H | 214 | G.S2.04 |
Hydrophobic | C-term | A | 885 | - | G.S2 | H | 214 | G.S2.04 |
Van-der-waals | C-term | A | 885 | - | G.S2 | H | 214 | G.S2.04 |