G13 -
mGlu4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 20.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | Y | 907 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | I | 912 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | I | 912 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | C-term | I | 912 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | ICL3 | T | 780 | - | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | S | 687 | 3x64 | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | Q | 902 | - | H.HD | R | 166 | H.HD.11 |
Polar | ICL2 | S | 689 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | S | 689 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 689 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | V | 688 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | T | 906 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | V | 905 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | TM3 | S | 687 | 3x64 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | TM3 | S | 687 | 3x64 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | V | 688 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | L | 367 | G.H5.16 |
Polar | C-term | T | 908 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | P | 881 | - | G.H2 | K | 231 | G.H2.05 |
Hydrophobic | C-term | P | 881 | - | G.H2 | K | 231 | G.H2.05 |
Van-der-waals | C-term | P | 881 | - | G.H2 | K | 231 | G.H2.05 |
Polar | C-term | Y | 904 | - | H.HD | R | 166 | H.HD.11 |
Hydrophobic | C-term | Y | 904 | - | H.HD | R | 166 | H.HD.11 |
Van-der-waals | C-term | Y | 904 | - | H.HD | R | 166 | H.HD.11 |
Hydrophobic | ICL2 | S | 689 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 689 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | C-term | Y | 904 | - | G.s4h3 | Q | 254 | G.s4h3.06 |
Polar | C-term | T | 906 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | T | 906 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | T | 906 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Aromatic | C-term | Y | 907 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | Y | 907 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | Y | 907 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | C-term | V | 863 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | A | 690 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | A | 690 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | Y | 904 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | Y | 904 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | TM3 | R | 686 | 3x63 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | TM3 | R | 686 | 3x63 | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | S | 870 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | S | 870 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | S | 870 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM3 | F | 681 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | F | 681 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | V | 905 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | V | 905 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | Y | 904 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | C-term | Y | 904 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Van-der-waals | C-term | Y | 904 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | C-term | Y | 907 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | Y | 907 | - | H.HA | D | 101 | H.HA.24 |
Polar | C-term | T | 908 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | T | 908 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | T | 908 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 680 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | Y | 907 | - | H.HA | A | 102 | H.HA.25 |
Hydrophobic | C-term | Y | 907 | - | H.HA | A | 102 | H.HA.25 |
Van-der-waals | C-term | Y | 907 | - | H.HA | A | 102 | H.HA.25 |
Polar | C-term | Y | 907 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | Y | 907 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | Y | 907 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | Y | 904 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | Y | 904 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | TM3 | R | 676 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 676 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL3 | P | 778 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | P | 778 | - | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | T | 780 | - | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | ICL3 | T | 780 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | V | 688 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | C-term | N | 882 | - | G.H2 | E | 229 | G.H2.03 |
Hydrophobic | C-term | N | 882 | - | G.H2 | E | 229 | G.H2.03 |
Van-der-waals | C-term | N | 882 | - | G.H2 | E | 229 | G.H2.03 |
Hydrophobic | C-term | H | 910 | - | H.HA | V | 98 | H.HA.21 |
Polar | C-term | A | 866 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | A | 866 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | A | 866 | - | G.H3 | R | 279 | G.H3.16 |
Polar | C-term | H | 910 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | C-term | H | 910 | - | H.HA | R | 97 | H.HA.20 |
Van-der-waals | C-term | H | 910 | - | H.HA | R | 97 | H.HA.20 |
Hydrophobic | ICL2 | V | 688 | - | G.S1 | V | 49 | G.S1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | H8 | K | 857 | 8x54 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | C-term | V | 905 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | V | 905 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | C-term | A | 867 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | A | 867 | - | G.H3 | R | 279 | G.H3.16 |