G15 -
mGlu4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | V | 363 | G.H5.15 |
Polar | C-term | E | 884 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Hydrophobic | C-term | E | 884 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Van-der-waals | C-term | E | 884 | - | G.hfs2 | G | 191 | G.hfs2.07 |
Hydrophobic | ICL2 | A | 690 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | A | 690 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | C-term | E | 888 | - | G.S2 | C | 196 | G.S2.05 |
Polar | C-term | C | 890 | - | G.S2 | C | 196 | G.S2.05 |
Polar | C-term | Y | 907 | - | G.HN | E | 27 | G.HN.42 |
Hydrophobic | C-term | Y | 907 | - | G.HN | E | 27 | G.HN.42 |
Van-der-waals | C-term | Y | 907 | - | G.HN | E | 27 | G.HN.42 |
Hydrophobic | C-term | Y | 907 | - | G.HN | I | 31 | G.HN.46 |
Van-der-waals | C-term | Y | 907 | - | G.HN | I | 31 | G.HN.46 |
Hydrophobic | C-term | G | 883 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | G | 883 | - | G.S2 | I | 192 | G.S2.01 |
Polar | C-term | N | 882 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | N | 882 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | N | 882 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | F | 879 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | F | 879 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | N | 882 | - | G.H2 | K | 218 | G.H2.06 |
Van-der-waals | C-term | N | 882 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | TM3 | F | 681 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | F | 681 | 3x58 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL2 | V | 688 | - | G.S3 | T | 202 | G.S3.01 |
Ionic | C-term | E | 884 | - | G.H2 | K | 218 | G.H2.06 |
Polar | C-term | E | 884 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | C-term | E | 884 | - | G.H2 | K | 218 | G.H2.06 |
Van-der-waals | C-term | E | 884 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | V | 359 | G.H5.11 |
Polar | C-term | P | 881 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | P | 881 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | P | 881 | - | G.H2 | H | 221 | G.H2.09 |
Polar | C-term | Y | 907 | - | G.HN | I | 28 | G.HN.43 |
Hydrophobic | C-term | Y | 907 | - | G.HN | I | 28 | G.HN.43 |
Van-der-waals | C-term | Y | 907 | - | G.HN | I | 28 | G.HN.43 |
Polar | C-term | P | 881 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | ICL1 | A | 620 | 12x52 | G.H5 | I | 371 | G.H5.23 |
Polar | C-term | K | 886 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | K | 886 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | K | 886 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | F | 879 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | TM3 | R | 676 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | G | 883 | - | G.H2 | K | 218 | G.H2.06 |
Van-der-waals | C-term | G | 883 | - | G.H2 | K | 218 | G.H2.06 |
Hydrophobic | C-term | V | 863 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | V | 863 | - | G.H3 | P | 265 | G.H3.16 |
Polar | C-term | E | 888 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | C-term | E | 888 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | E | 888 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | ICL3 | E | 783 | - | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | S | 687 | 3x64 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | G | 883 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | G | 883 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | G | 883 | - | G.H2 | H | 221 | G.H2.09 |
Polar | C-term | E | 888 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | E | 888 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | V | 905 | - | G.HN | I | 31 | G.HN.46 |
Van-der-waals | C-term | V | 905 | - | G.HN | I | 31 | G.HN.46 |
Polar | H8 | K | 855 | 8x52 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | V | 688 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.S1 | L | 43 | G.S1.02 |
Polar | ICL1 | P | 616 | 12x48 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | ICL1 | P | 616 | 12x48 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | N | 878 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | N | 878 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | N | 878 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | R | 880 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | F | 879 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | F | 879 | - | G.H2 | R | 216 | G.H2.04 |
Polar | C-term | R | 880 | - | G.H2 | K | 218 | G.H2.06 |
Polar | C-term | A | 885 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | A | 885 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | A | 885 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 680 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | R | 360 | G.H5.12 |
Ionic | H8 | K | 855 | 8x52 | G.H5 | D | 369 | G.H5.21 |
Polar | H8 | K | 855 | 8x52 | G.H5 | D | 369 | G.H5.21 |
Polar | C-term | E | 884 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | E | 884 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | E | 884 | - | G.S2 | I | 192 | G.S2.01 |
Polar | C-term | K | 886 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | K | 886 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | ICL1 | A | 620 | 12x52 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | S | 887 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | S | 887 | - | G.S2 | E | 194 | G.S2.03 |
Ionic | C-term | E | 888 | - | G.H1 | R | 63 | G.H1.09 |
Polar | C-term | E | 888 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | C | 890 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | ICL2 | I | 694 | - | G.H5 | Y | 367 | G.H5.19 |
Polar | TM3 | G | 684 | 3x61 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM3 | G | 684 | 3x61 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | F | 879 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | F | 879 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | A | 885 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | Y | 907 | - | G.HN | V | 24 | G.HN.39 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Polar | TM3 | K | 685 | 3x62 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM3 | K | 685 | 3x62 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM3 | K | 685 | 3x62 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | K | 886 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | K | 886 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | A | 867 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | C-term | P | 881 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | P | 881 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | TM3 | R | 686 | 3x63 | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | R | 880 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | R | 880 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | R | 880 | - | G.H2 | K | 217 | G.H2.05 |