Golf -
mGlu4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | R | 856 | 8x53 | G.h4s6 | S | 336 | G.h4s6.02 |
Hydrophobic | C-term | F | 873 | - | G.hgh4 | E | 301 | G.hgh4.04 |
Van-der-waals | C-term | F | 873 | - | G.hgh4 | E | 301 | G.hgh4.04 |
Hydrophobic | TM3 | R | 676 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 676 | 3x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | ICL1 | A | 620 | 12x52 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | R | 856 | 8x53 | G.h4s6 | G | 340 | G.h4s6.09 |
Hydrophobic | H8 | R | 856 | 8x53 | G.h4s6 | G | 340 | G.h4s6.09 |
Van-der-waals | H8 | R | 856 | 8x53 | G.h4s6 | G | 340 | G.h4s6.09 |
Polar | C-term | Q | 902 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | Q | 902 | - | G.H2 | Q | 223 | G.H2.09 |
Van-der-waals | C-term | V | 905 | - | G.S2 | E | 196 | G.S2.03 |
Van-der-waals | C-term | Y | 907 | - | H.HA | E | 74 | H.HA.03 |
Polar | H8 | R | 856 | 8x53 | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | H8 | R | 856 | 8x53 | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | TM4 | S | 695 | 4x28 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM4 | S | 695 | 4x28 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM4 | S | 695 | 4x28 | G.H5 | Y | 378 | G.H5.23 |
Polar | C-term | Y | 907 | - | G.H1 | R | 63 | G.H1.09 |
Aromatic | C-term | Y | 907 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | Y | 907 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | Y | 907 | - | G.H1 | R | 63 | G.H1.09 |
Polar | ICL2 | V | 688 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | L | 893 | - | G.H2 | I | 222 | G.H2.08 |
Van-der-waals | C-term | L | 893 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | ICL1 | S | 621 | 12x53 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | A | 690 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | A | 690 | - | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | A | 690 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | TM3 | G | 684 | 3x61 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM4 | P | 696 | 4x29 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM2 | G | 622 | 2x35 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | N | 909 | - | G.h1ha | V | 67 | G.h1ha.01 |
Hydrophobic | TM3 | K | 685 | 3x62 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | TM3 | K | 685 | 3x62 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | R | 372 | G.H5.17 |
Polar | C-term | T | 865 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | T | 865 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | L | 889 | - | G.H2 | W | 221 | G.H2.07 |
Polar | C-term | C | 890 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | C | 890 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | C | 890 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | H8 | R | 856 | 8x53 | G.h4s6 | D | 341 | G.h4s6.10 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | S | 689 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | H8 | L | 860 | 8x57 | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | H8 | L | 860 | 8x57 | G.h4s6 | T | 337 | G.h4s6.03 |
Polar | ICL1 | A | 620 | 12x52 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL1 | A | 620 | 12x52 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | F | 681 | 3x58 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | V | 688 | - | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | V | 688 | - | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | C-term | L | 889 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Van-der-waals | C-term | L | 889 | - | G.h2s4 | F | 225 | G.h2s4.01 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL1 | K | 619 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | ICL1 | K | 619 | 12x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | C-term | V | 863 | - | G.H4 | L | 333 | G.H4.16 |
Van-der-waals | C-term | V | 863 | - | G.H4 | L | 333 | G.H4.16 |
Hydrophobic | C-term | K | 861 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | K | 861 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | A | 866 | - | G.H4 | D | 330 | G.H4.13 |
Hydrophobic | ICL2 | P | 691 | - | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | R | 686 | 3x63 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | TM3 | R | 686 | 3x63 | G.S3 | V | 204 | G.S3.01 |
Polar | C-term | A | 862 | - | G.H4 | R | 329 | G.H4.12 |
Hydrophobic | C-term | A | 862 | - | G.H4 | R | 329 | G.H4.12 |
Van-der-waals | C-term | A | 862 | - | G.H4 | R | 329 | G.H4.12 |
Ionic | H8 | K | 857 | 8x54 | G.H5 | D | 368 | G.H5.13 |
Polar | H8 | K | 857 | 8x54 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | H8 | K | 857 | 8x54 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | H8 | R | 856 | 8x53 | G.h4s6 | G | 342 | G.h4s6.11 |
Hydrophobic | ICL2 | V | 688 | - | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | V | 688 | - | G.H5 | I | 370 | G.H5.15 |
Polar | TM3 | F | 681 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | F | 681 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | F | 681 | 3x58 | G.H5 | Q | 371 | G.H5.16 |
Polar | C-term | C | 890 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | C | 890 | - | G.H3 | W | 268 | G.H3.17 |
Van-der-waals | C-term | C | 890 | - | G.H3 | W | 268 | G.H3.17 |
Hydrophobic | C-term | T | 906 | - | G.S2 | R | 198 | G.S2.05 |
Hydrophobic | H8 | R | 856 | 8x53 | G.h4s6 | Y | 345 | G.h4s6.20 |
Van-der-waals | C-term | L | 889 | - | G.H2 | I | 222 | G.H2.08 |
Hydrophobic | C-term | T | 865 | - | G.hgh4 | P | 308 | G.hgh4.11 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | F | 873 | - | G.hgh4 | N | 304 | G.hgh4.07 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | M | 869 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Van-der-waals | C-term | M | 869 | - | G.hgh4 | T | 306 | G.hgh4.09 |
Hydrophobic | H8 | K | 857 | 8x54 | G.H5 | R | 372 | G.H5.17 |
Van-der-waals | H8 | K | 857 | 8x54 | G.H5 | R | 372 | G.H5.17 |
Polar | C-term | A | 862 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Hydrophobic | C-term | A | 862 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Van-der-waals | C-term | A | 862 | - | G.hgh4 | D | 310 | G.hgh4.13 |
Polar | TM3 | R | 676 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 676 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 676 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | C-term | M | 869 | - | G.hgh4 | Y | 305 | G.hgh4.08 |
Hydrophobic | ICL2 | I | 694 | - | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | I | 694 | - | G.H5 | Y | 378 | G.H5.23 |
Ionic | C-term | E | 888 | - | G.H2 | R | 219 | G.H2.05 |
Polar | C-term | E | 888 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | C-term | E | 888 | - | G.H2 | R | 219 | G.H2.05 |
Van-der-waals | C-term | E | 888 | - | G.H2 | R | 219 | G.H2.05 |
Hydrophobic | C-term | V | 863 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Van-der-waals | C-term | V | 863 | - | G.h4s6 | T | 337 | G.h4s6.03 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | V | 905 | - | G.S2 | F | 195 | G.S2.02 |