Gs - mGlu4 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 19.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 K 685 3x62 G.H5 R 380 G.H5.12
Hydrophobic TM3 K 685 3x62 G.H5 R 380 G.H5.12
Van-der-waals TM3 K 685 3x62 G.H5 R 380 G.H5.12
Polar TM3 G 684 3x61 G.H5 Q 384 G.H5.16
Hydrophobic TM3 G 684 3x61 G.H5 Q 384 G.H5.16
Van-der-waals TM3 G 684 3x61 G.H5 Q 384 G.H5.16
Hydrophobic C-term V 864 - G.h3s5 T 284 G.h3s5.02
Hydrophobic ICL2 P 691 - G.H5 H 387 G.H5.19
Hydrophobic C-term A 911 - H.hbhc P 138 H.hbhc.02
Van-der-waals C-term A 911 - H.hbhc P 138 H.hbhc.02
Hydrophobic ICL2 V 688 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 V 688 - G.S1 H 41 G.S1.02
Polar TM3 F 681 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 F 681 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 F 681 3x58 G.H5 Q 384 G.H5.16
Polar C-term H 910 - H.HB N 136 H.HB.14
Hydrophobic C-term H 910 - H.HB N 136 H.HB.14
Van-der-waals C-term H 910 - H.HB N 136 H.HB.14
Hydrophobic ICL2 V 688 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 V 688 - G.S3 V 217 G.S3.01
Aromatic TM3 R 676 3x53 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 676 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 676 3x53 G.H5 Y 391 G.H5.23
Polar C-term I 912 - H.hbhc P 138 H.hbhc.02
Hydrophobic C-term I 912 - H.hbhc P 138 H.hbhc.02
Van-der-waals C-term I 912 - H.hbhc P 138 H.hbhc.02
Ionic ICL1 K 619 12x51 G.H5 E 392 G.H5.24
Polar ICL1 K 619 12x51 G.H5 E 392 G.H5.24
Hydrophobic ICL1 K 619 12x51 G.H5 E 392 G.H5.24
Van-der-waals ICL1 K 619 12x51 G.H5 E 392 G.H5.24
Ionic C-term E 884 - G.H2 R 232 G.H2.05
Polar C-term E 884 - G.H2 R 232 G.H2.05
Hydrophobic C-term E 884 - G.H2 R 232 G.H2.05
Van-der-waals C-term E 884 - G.H2 R 232 G.H2.05
Hydrophobic ICL3 F 781 - G.H5 L 393 G.H5.25
Van-der-waals ICL3 F 781 - G.H5 L 393 G.H5.25
Polar C-term N 882 - G.H3 R 280 G.H3.16
Hydrophobic C-term N 882 - G.H3 R 280 G.H3.16
Van-der-waals C-term N 882 - G.H3 R 280 G.H3.16
Hydrophobic C-term Y 907 - H.HB M 135 H.HB.13
Polar ICL1 A 620 12x52 G.H5 E 392 G.H5.24
Hydrophobic ICL1 A 620 12x52 G.H5 E 392 G.H5.24
Van-der-waals ICL1 A 620 12x52 G.H5 E 392 G.H5.24
Hydrophobic TM3 I 680 3x57 G.H5 Y 391 G.H5.23
Hydrophobic TM3 F 681 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 F 681 3x58 G.H5 L 388 G.H5.20
Van-der-waals TM3 K 685 3x62 G.H5 Q 384 G.H5.16
Hydrophobic ICL2 A 690 - G.H5 H 387 G.H5.19
Van-der-waals ICL2 A 690 - G.H5 H 387 G.H5.19
Hydrophobic ICL3 F 781 - G.H5 L 388 G.H5.20
Van-der-waals ICL3 F 781 - G.H5 L 388 G.H5.20
Polar C-term I 912 - H.hbhc D 139 H.hbhc.03
Hydrophobic C-term I 912 - H.hbhc D 139 H.hbhc.03
Van-der-waals C-term I 912 - H.hbhc D 139 H.hbhc.03
Hydrophobic TM3 G 684 3x61 G.H5 R 380 G.H5.12
Van-der-waals TM3 G 684 3x61 G.H5 R 380 G.H5.12
Polar C-term I 912 - H.HB N 136 H.HB.14
Hydrophobic H8 L 860 8x57 G.H5 Q 390 G.H5.22
Hydrophobic TM3 I 680 3x57 G.H5 L 388 G.H5.20
Van-der-waals TM3 I 680 3x57 G.H5 L 388 G.H5.20
Hydrophobic ICL2 V 688 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 V 688 - G.H5 I 383 G.H5.15
Hydrophobic ICL3 F 781 - G.H5 R 385 G.H5.17
Hydrophobic C-term V 864 - G.h2s4 N 239 G.h2s4.02
Van-der-waals C-term V 864 - G.h2s4 N 239 G.h2s4.02
Hydrophobic C-term T 868 - G.H3 R 280 G.H3.16
Van-der-waals C-term T 868 - G.H3 R 280 G.H3.16
Hydrophobic TM3 I 680 3x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 I 680 3x57 G.H5 H 387 G.H5.19
Hydrophobic C-term A 867 - G.h4s6 R 356 G.h4s6.12
Van-der-waals C-term A 867 - G.h4s6 R 356 G.h4s6.12
Hydrophobic ICL3 F 781 - G.H5 L 394 G.H5.26
Van-der-waals ICL3 F 781 - G.H5 L 394 G.H5.26
Hydrophobic ICL2 I 694 - G.H5 Y 391 G.H5.23
Van-der-waals ICL2 I 694 - G.H5 Y 391 G.H5.23
Hydrophobic C-term I 912 - H.hbhc V 137 H.hbhc.01
Van-der-waals C-term I 912 - H.hbhc V 137 H.hbhc.01
Polar C-term H 910 - H.hbhc P 138 H.hbhc.02
Hydrophobic C-term H 910 - H.hbhc P 138 H.hbhc.02
Van-der-waals C-term H 910 - H.hbhc P 138 H.hbhc.02
Hydrophobic ICL1 A 620 12x52 G.H5 L 393 G.H5.25
Van-der-waals ICL1 A 620 12x52 G.H5 L 393 G.H5.25
Polar C-term Y 904 - G.s4h3 D 260 G.s4h3.11
Hydrophobic C-term T 868 - G.H3 W 281 G.H3.17