Ggust -
mGlu4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | TM3 | K | 685 | 3x62 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | C-term | L | 893 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | L | 893 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | F | 879 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | F | 879 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | L | 889 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | L | 889 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 893 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | V | 688 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | F | 681 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | F | 681 | 3x58 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | A | 867 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Polar | ICL2 | V | 688 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | V | 688 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.hns1 | A | 31 | G.hns1.02 |
Ionic | C-term | E | 888 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | E | 888 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | E | 888 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | E | 888 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM3 | K | 685 | 3x62 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM3 | K | 685 | 3x62 | G.H5 | T | 340 | G.H5.12 |
Ionic | C-term | R | 880 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | R | 880 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | R | 880 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | R | 880 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 889 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | H8 | K | 855 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | H8 | K | 855 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | S | 689 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | S | 689 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | S | 689 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 893 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | L | 893 | - | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | L | 893 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | ICL3 | F | 781 | - | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | N | 882 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | N | 882 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | ICL1 | K | 619 | 12x51 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | ICL1 | K | 619 | 12x51 | G.H5 | G | 352 | G.H5.24 |
Polar | ICL1 | A | 620 | 12x52 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | P | 691 | - | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | A | 690 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | A | 690 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | A | 690 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | L | 889 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | L | 889 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL1 | A | 620 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | ICL1 | A | 620 | 12x52 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | V | 688 | - | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | TM3 | S | 687 | 3x64 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | TM3 | S | 687 | 3x64 | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | N | 882 | - | G.s4h3 | N | 241 | G.s4h3.15 |
Polar | H8 | R | 856 | 8x53 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | H8 | R | 856 | 8x53 | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM3 | K | 685 | 3x62 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | I | 680 | 3x57 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | S | 687 | 3x64 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | TM3 | S | 687 | 3x64 | G.S3 | L | 194 | G.S3.01 |
Polar | C-term | S | 887 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | C-term | S | 887 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | ICL3 | F | 781 | - | G.H5 | K | 345 | G.H5.17 |
Polar | ICL2 | I | 694 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | I | 694 | - | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | ICL2 | I | 694 | - | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | V | 863 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Van-der-waals | C-term | V | 863 | - | G.h4s6 | L | 312 | G.h4s6.03 |
Polar | C-term | L | 889 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM2 | G | 622 | 2x35 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | C | 890 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | C | 890 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | N | 882 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Van-der-waals | C-term | N | 882 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Ionic | TM3 | R | 686 | 3x63 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM3 | R | 686 | 3x63 | G.s2s3 | D | 193 | G.s2s3.02 |
Aromatic | C-term | F | 873 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | F | 873 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | F | 873 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | F | 873 | - | G.H3 | L | 247 | G.H3.06 |
Hydrophobic | ICL2 | V | 688 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | V | 688 | - | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | V | 688 | - | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL1 | S | 621 | 12x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | K | 685 | 3x62 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM3 | R | 686 | 3x63 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | TM3 | R | 686 | 3x63 | G.S3 | L | 194 | G.S3.01 |
Polar | TM3 | R | 676 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 676 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 676 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | G | 684 | 3x61 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | TM3 | G | 684 | 3x61 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | R | 676 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 676 | 3x53 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | I | 680 | 3x57 | G.H5 | N | 347 | G.H5.19 |
Polar | TM3 | S | 687 | 3x64 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | TM3 | S | 687 | 3x64 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | I | 680 | 3x57 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | V | 688 | - | G.S3 | L | 194 | G.S3.01 |