G11 -
mGlu5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.8
PAE mean: 13.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | F | 837 | 8x54 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | H8 | F | 837 | 8x54 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL2 | I | 680 | - | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | I | 680 | - | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | C-term | G | 848 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Ionic | ICL2 | K | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | ICL2 | K | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | ICL2 | K | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 679 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | C-term | G | 848 | - | G.h4s6 | K | 322 | G.h4s6.13 |
Hydrophobic | C-term | G | 850 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | G | 850 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL2 | I | 680 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | I | 680 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | V | 842 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | V | 842 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | R | 844 | - | G.S6 | Y | 325 | G.S6.02 |
Polar | ICL2 | K | 679 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 679 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 679 | - | G.s2s3 | N | 198 | G.s2s3.02 |
Hydrophobic | C-term | V | 847 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | V | 847 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL2 | T | 682 | - | G.S1 | L | 40 | G.S1.02 |
Polar | ICL3 | N | 767 | - | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL3 | N | 767 | - | G.H5 | L | 358 | G.H5.25 |
Polar | ICL2 | K | 677 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | K | 677 | - | G.H5 | K | 345 | G.H5.12 |
Ionic | ICL2 | K | 684 | - | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | K | 684 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | K | 684 | - | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | K | 684 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | I | 672 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 672 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Polar | TM3 | R | 668 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 668 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 668 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | F | 837 | 8x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | H8 | F | 837 | 8x54 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | H | 846 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | C-term | H | 846 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | C-term | H | 846 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | C-term | V | 843 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | C-term | V | 843 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | C-term | V | 843 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | V | 843 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL2 | I | 680 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL1 | S | 612 | 12x52 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL1 | S | 612 | 12x52 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | R | 932 | - | G.H4 | V | 314 | G.H4.16 |
Polar | ICL2 | T | 682 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | T | 682 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | T | 682 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | C-term | W | 930 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | W | 930 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | C-term | W | 930 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | S | 840 | 8x57 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | R | 844 | - | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | C-term | R | 844 | - | G.S6 | F | 328 | G.S6.05 |
Van-der-waals | ICL3 | N | 767 | - | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | G | 848 | - | G.h4s6 | D | 319 | G.h4s6.10 |
Hydrophobic | C-term | G | 848 | - | G.h4s6 | D | 319 | G.h4s6.10 |
Hydrophobic | TM3 | I | 672 | 3x57 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | L | 673 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | C-term | H | 846 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | H8 | R | 834 | 8x51 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | H8 | R | 834 | 8x51 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | R | 834 | 8x51 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | T | 682 | - | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | T | 682 | - | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | ICL2 | S | 676 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | H8 | A | 836 | 8x53 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | ICL2 | M | 688 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | M | 688 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | I | 672 | 3x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | V | 843 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | C-term | V | 843 | - | G.H5 | A | 342 | G.H5.09 |
Ionic | C-term | R | 844 | - | G.H4 | E | 307 | G.H4.09 |
Polar | C-term | R | 844 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | C-term | R | 844 | - | G.H4 | E | 307 | G.H4.09 |
Van-der-waals | C-term | R | 844 | - | G.H4 | E | 307 | G.H4.09 |
Hydrophobic | C-term | D | 849 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | H8 | T | 839 | 8x56 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | H8 | T | 839 | 8x56 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | M | 845 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | H8 | S | 840 | 8x57 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL1 | S | 612 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | S | 612 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Ionic | C-term | R | 932 | - | G.H4 | D | 315 | G.H4.17 |
Polar | C-term | R | 932 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | C-term | R | 932 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | C-term | R | 932 | - | G.H4 | D | 315 | G.H4.17 |
Polar | ICL2 | S | 676 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | S | 676 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | S | 676 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | H | 846 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | C-term | H | 846 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | C-term | W | 930 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | I | 680 | - | G.S3 | F | 201 | G.S3.03 |
Polar | C-term | R | 844 | - | G.S6 | S | 326 | G.S6.03 |
Van-der-waals | C-term | R | 844 | - | G.S6 | S | 326 | G.S6.03 |
Polar | C-term | S | 955 | - | G.hgh4 | D | 296 | G.hgh4.06 |
Van-der-waals | C-term | S | 955 | - | G.hgh4 | D | 296 | G.hgh4.06 |
Hydrophobic | TM3 | I | 672 | 3x57 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | H | 846 | - | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | ICL2 | I | 680 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | I | 680 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | K | 679 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | M | 845 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | C-term | M | 845 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | H8 | T | 838 | 8x55 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | H8 | T | 838 | 8x55 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | H8 | T | 838 | 8x55 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | V | 843 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | C-term | G | 848 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Van-der-waals | C-term | G | 848 | - | G.h4s6 | N | 317 | G.h4s6.08 |
Hydrophobic | H8 | T | 839 | 8x56 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | H8 | T | 839 | 8x56 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | I | 680 | - | G.H5 | V | 344 | G.H5.11 |
Hydrophobic | C-term | W | 930 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | W | 930 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM3 | I | 672 | 3x57 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 672 | 3x57 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | I | 680 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | I | 680 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | R | 668 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | H | 846 | - | G.S6 | I | 324 | G.S6.01 |
Hydrophobic | C-term | H | 846 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | C-term | H | 846 | - | G.S6 | I | 324 | G.S6.01 |