G13 -
mGlu7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 23.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | H8 | R | 861 | 8x55 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | R | 861 | 8x55 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | ICL2 | V | 691 | - | G.S1 | V | 49 | G.S1.02 |
Van-der-waals | ICL2 | V | 691 | - | G.S1 | V | 49 | G.S1.02 |
Polar | H8 | K | 860 | 8x54 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | H8 | K | 860 | 8x54 | G.h3s5 | N | 283 | G.h3s5.02 |
Van-der-waals | H8 | K | 860 | 8x54 | G.h3s5 | N | 283 | G.h3s5.02 |
Hydrophobic | C-term | P | 880 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | P | 880 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | C-term | A | 888 | - | G.S6 | H | 344 | G.S6.03 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | C-term | N | 885 | - | G.HG | L | 296 | G.HG.04 |
Van-der-waals | C-term | N | 885 | - | G.HG | L | 296 | G.HG.04 |
Polar | C-term | D | 882 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | C-term | D | 882 | - | G.H4 | V | 327 | G.H4.12 |
Van-der-waals | C-term | D | 882 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | G | 886 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | ICL2 | K | 689 | - | G.s2s3 | N | 215 | G.s2s3.02 |
Hydrophobic | C-term | D | 882 | - | G.H4 | F | 325 | G.H4.10 |
Van-der-waals | C-term | D | 882 | - | G.H4 | F | 325 | G.H4.10 |
Polar | C-term | P | 880 | - | G.H4 | C | 329 | G.H4.14 |
Hydrophobic | C-term | P | 880 | - | G.H4 | C | 329 | G.H4.14 |
Van-der-waals | C-term | P | 880 | - | G.H4 | C | 329 | G.H4.14 |
Polar | C-term | S | 873 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Van-der-waals | C-term | S | 873 | - | G.h4s6 | R | 335 | G.h4s6.09 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Ionic | C-term | E | 887 | - | G.H4 | R | 320 | G.H4.05 |
Polar | C-term | E | 887 | - | G.H4 | R | 320 | G.H4.05 |
Van-der-waals | C-term | E | 887 | - | G.H4 | R | 320 | G.H4.05 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | R | 883 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | C-term | R | 883 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL2 | V | 691 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | V | 691 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | V | 691 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | T | 692 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | T | 692 | - | G.H5 | L | 374 | G.H5.23 |
Polar | H8 | K | 858 | 8x52 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | H8 | K | 858 | 8x52 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | H8 | K | 858 | 8x52 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL2 | G | 687 | - | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Ionic | C-term | E | 891 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Polar | C-term | E | 891 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Van-der-waals | C-term | E | 891 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Hydrophobic | ICL2 | K | 688 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | C-term | E | 891 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | C-term | E | 891 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | C-term | E | 891 | - | G.S6 | L | 342 | G.S6.01 |
Van-der-waals | C-term | E | 891 | - | G.S6 | L | 342 | G.S6.01 |
Polar | C-term | D | 882 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | C-term | D | 882 | - | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | C-term | D | 882 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | C-term | P | 880 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Van-der-waals | C-term | P | 880 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Polar | ICL2 | R | 695 | - | G.HN | S | 39 | G.HN.48 |
Hydrophobic | ICL2 | S | 690 | - | G.S3 | V | 216 | G.S3.01 |
Ionic | H8 | R | 861 | 8x55 | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | H8 | R | 861 | 8x55 | G.h4s6 | D | 336 | G.h4s6.10 |
Van-der-waals | H8 | R | 861 | 8x55 | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | ICL2 | V | 691 | - | G.h2s4 | T | 241 | G.h2s4.05 |
Polar | H8 | S | 862 | 8x56 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | H8 | S | 862 | 8x56 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | S | 862 | 8x56 | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | H8 | F | 863 | 8x57 | G.H3 | V | 280 | G.H3.17 |
Van-der-waals | H8 | F | 863 | 8x57 | G.H3 | V | 280 | G.H3.17 |
Polar | ICL2 | T | 692 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | T | 692 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM3 | F | 684 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | F | 684 | 3x58 | G.H5 | L | 371 | G.H5.20 |
Polar | ICL2 | K | 689 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | ICL2 | K | 689 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | K | 689 | - | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | C-term | V | 866 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | V | 866 | - | G.H3 | R | 279 | G.H3.16 |
Polar | C-term | R | 883 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | C-term | R | 883 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | C-term | R | 883 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | ICL2 | V | 691 | - | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 691 | - | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | S | 881 | - | G.H4 | C | 329 | G.H4.14 |
Hydrophobic | C-term | S | 881 | - | G.H4 | C | 329 | G.H4.14 |
Van-der-waals | C-term | S | 881 | - | G.H4 | C | 329 | G.H4.14 |
Hydrophobic | C-term | T | 890 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | C-term | T | 890 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | C-term | L | 892 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | ICL2 | R | 695 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | R | 695 | - | G.HN | T | 43 | G.HN.52 |
Polar | C-term | S | 877 | - | G.h4s6 | K | 333 | G.h4s6.01 |
Van-der-waals | C-term | S | 877 | - | G.h4s6 | K | 333 | G.h4s6.01 |
Ionic | C-term | E | 891 | - | G.H4 | R | 331 | G.H4.16 |
Polar | C-term | E | 891 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | C-term | E | 891 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | C-term | E | 891 | - | G.H4 | R | 331 | G.H4.16 |
Ionic | C-term | R | 883 | - | G.H4 | E | 328 | G.H4.13 |
Polar | C-term | R | 883 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | C-term | R | 883 | - | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | C-term | R | 883 | - | G.H4 | E | 328 | G.H4.13 |
Polar | C-term | D | 882 | - | G.H4 | L | 326 | G.H4.11 |
Hydrophobic | C-term | D | 882 | - | G.H4 | L | 326 | G.H4.11 |
Van-der-waals | C-term | D | 882 | - | G.H4 | L | 326 | G.H4.11 |
Hydrophobic | ICL2 | T | 692 | - | G.HN | T | 43 | G.HN.52 |
Van-der-waals | ICL2 | T | 692 | - | G.HN | T | 43 | G.HN.52 |
Polar | C-term | N | 885 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | C-term | N | 885 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | C-term | N | 885 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | ICL2 | V | 691 | - | G.H5 | N | 370 | G.H5.19 |
Polar | C-term | N | 885 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | C-term | N | 885 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | C-term | N | 885 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | ICL3 | P | 781 | - | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | ICL3 | P | 781 | - | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | S | 881 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | C-term | S | 881 | - | G.H4 | E | 328 | G.H4.13 |
Van-der-waals | C-term | S | 881 | - | G.H4 | E | 328 | G.H4.13 |
Hydrophobic | H8 | F | 863 | 8x57 | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | H8 | F | 863 | 8x57 | G.H3 | R | 279 | G.H3.16 |
Polar | ICL2 | T | 692 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | T | 692 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | G | 687 | - | G.H5 | L | 367 | G.H5.16 |
Polar | TM3 | Q | 686 | 3x60 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | P | 884 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | C-term | P | 884 | - | G.H4 | K | 324 | G.H4.09 |
Polar | C-term | K | 889 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | C-term | K | 889 | - | G.S6 | H | 344 | G.S6.03 |
Van-der-waals | C-term | K | 889 | - | G.S6 | H | 344 | G.S6.03 |
Hydrophobic | C-term | P | 880 | - | G.H4 | F | 325 | G.H4.10 |
Van-der-waals | C-term | P | 880 | - | G.H4 | F | 325 | G.H4.10 |
Polar | C-term | D | 882 | - | G.H4 | C | 329 | G.H4.14 |
Van-der-waals | C-term | D | 882 | - | G.H4 | C | 329 | G.H4.14 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | I | 683 | 3x57 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | S | 881 | - | G.H4 | N | 332 | G.H4.17 |
Van-der-waals | C-term | S | 881 | - | G.H4 | N | 332 | G.H4.17 |
Polar | H8 | K | 858 | 8x52 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | H8 | K | 858 | 8x52 | G.h4s6 | Q | 338 | G.h4s6.12 |
Polar | C-term | P | 884 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | C-term | P | 884 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | C-term | P | 884 | - | G.H4 | Q | 323 | G.H4.08 |
Polar | C-term | N | 885 | - | G.HG | T | 293 | G.HG.01 |
Hydrophobic | C-term | N | 885 | - | G.HG | T | 293 | G.HG.01 |
Van-der-waals | C-term | N | 885 | - | G.HG | T | 293 | G.HG.01 |
Hydrophobic | C-term | V | 866 | - | G.H3 | N | 278 | G.H3.15 |
Polar | C-term | R | 883 | - | G.H4 | Q | 323 | G.H4.08 |
Hydrophobic | C-term | R | 883 | - | G.H4 | Q | 323 | G.H4.08 |
Van-der-waals | C-term | R | 883 | - | G.H4 | Q | 323 | G.H4.08 |
Polar | C-term | R | 883 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | C-term | R | 883 | - | G.H4 | V | 327 | G.H4.12 |
Van-der-waals | C-term | R | 883 | - | G.H4 | V | 327 | G.H4.12 |
Hydrophobic | C-term | P | 884 | - | G.S6 | F | 346 | G.S6.05 |
Van-der-waals | C-term | P | 884 | - | G.S6 | F | 346 | G.S6.05 |
Hydrophobic | ICL2 | K | 688 | - | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | C-term | S | 881 | - | G.H4 | F | 325 | G.H4.10 |
Van-der-waals | C-term | S | 881 | - | G.H4 | F | 325 | G.H4.10 |
Hydrophobic | C-term | A | 888 | - | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | C-term | A | 888 | - | G.S6 | H | 345 | G.S6.04 |
Polar | ICL2 | S | 690 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | S | 690 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | S | 690 | - | G.hns1 | R | 47 | G.hns1.03 |
Polar | C-term | R | 883 | - | G.H4 | L | 326 | G.H4.11 |
Van-der-waals | C-term | R | 883 | - | G.H4 | L | 326 | G.H4.11 |
Hydrophobic | ICL3 | N | 783 | - | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ICL2 | A | 693 | - | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | ICL2 | A | 693 | - | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | V | 691 | - | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | ICL2 | V | 691 | - | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | A | 865 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | A | 865 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | A | 865 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | I | 683 | 3x57 | G.H5 | L | 371 | G.H5.20 |
Ionic | C-term | K | 879 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Polar | C-term | K | 879 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | C-term | K | 879 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | K | 879 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Ionic | C-term | D | 882 | - | G.H4 | K | 324 | G.H4.09 |
Polar | C-term | D | 882 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | C-term | D | 882 | - | G.H4 | K | 324 | G.H4.09 |
Van-der-waals | C-term | D | 882 | - | G.H4 | K | 324 | G.H4.09 |
Hydrophobic | TM3 | I | 680 | 3x54 | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | M | 375 | G.H5.24 |