Gq -
mGlu7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 876 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | C-term | V | 867 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | V | 867 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | A | 888 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | A | 888 | - | G.S2 | I | 190 | G.S2.02 |
Polar | ICL2 | G | 687 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | G | 687 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | G | 687 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | H8 | F | 863 | 8x57 | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | ICL2 | V | 691 | - | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | V | 691 | - | G.S1 | L | 40 | G.S1.02 |
Polar | C-term | S | 877 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | C-term | S | 877 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | C-term | S | 877 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | C-term | N | 885 | - | G.S2 | D | 195 | G.S2.07 |
Hydrophobic | C-term | N | 885 | - | G.S2 | D | 195 | G.S2.07 |
Van-der-waals | C-term | N | 885 | - | G.S2 | D | 195 | G.S2.07 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | C-term | H | 878 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | C-term | K | 889 | - | G.S2 | P | 193 | G.S2.05 |
Polar | C-term | E | 887 | - | G.h1ha | S | 65 | G.h1ha.02 |
Hydrophobic | TM3 | F | 684 | 3x58 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | V | 691 | - | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | V | 691 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | G | 886 | - | G.S2 | F | 194 | G.S2.06 |
Van-der-waals | C-term | G | 886 | - | G.S2 | F | 194 | G.S2.06 |
Polar | C-term | T | 890 | - | G.S2 | E | 191 | G.S2.03 |
Polar | C-term | L | 892 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | C-term | L | 892 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | C-term | L | 892 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | R | 38 | G.hns1.03 |
Polar | C-term | G | 886 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | C-term | G | 886 | - | G.S2 | P | 193 | G.S2.05 |
Van-der-waals | C-term | G | 886 | - | G.S2 | P | 193 | G.S2.05 |
Polar | ICL1 | S | 624 | 12x53 | G.H5 | N | 357 | G.H5.24 |
Ionic | H8 | R | 859 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | K | 879 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | C-term | K | 879 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Aromatic | H8 | F | 863 | 8x57 | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | H8 | F | 863 | 8x57 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | H8 | F | 863 | 8x57 | G.H5 | F | 339 | G.H5.06 |
Aromatic | H8 | F | 863 | 8x57 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | H8 | F | 863 | 8x57 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | H8 | F | 863 | 8x57 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | C-term | E | 887 | - | G.S2 | P | 193 | G.S2.05 |
Hydrophobic | C-term | L | 876 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | N | 885 | - | G.h1ha | G | 64 | G.h1ha.01 |
Van-der-waals | C-term | N | 885 | - | G.h1ha | G | 64 | G.h1ha.01 |
Hydrophobic | C-term | A | 870 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | C-term | A | 870 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | C-term | C | 893 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | L | 876 | - | G.S2 | L | 196 | G.S2.08 |
Van-der-waals | C-term | L | 876 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | ICL2 | A | 693 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | A | 693 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL1 | R | 622 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL1 | R | 622 | 12x51 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | V | 866 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | C-term | V | 866 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | G | 886 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | G | 886 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | H8 | K | 860 | 8x54 | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | ICL1 | A | 623 | 12x52 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | V | 359 | G.H5.26 |
Polar | ICL1 | A | 623 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | H | 878 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Hydrophobic | C-term | H | 878 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Van-der-waals | C-term | H | 878 | - | G.s2s3 | Q | 197 | G.s2s3.01 |
Polar | C-term | H | 878 | - | G.H1 | I | 62 | G.H1.11 |
Hydrophobic | C-term | G | 886 | - | G.H1 | R | 60 | G.H1.09 |
Polar | ICL2 | K | 688 | - | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | K | 688 | - | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | K | 688 | - | G.H5 | K | 345 | G.H5.12 |
Polar | C-term | N | 885 | - | G.h1ha | S | 65 | G.h1ha.02 |
Van-der-waals | C-term | N | 885 | - | G.h1ha | S | 65 | G.h1ha.02 |
Polar | TM2 | G | 625 | 2x35 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | N | 885 | - | G.S2 | F | 194 | G.S2.06 |
Van-der-waals | C-term | N | 885 | - | G.S2 | F | 194 | G.S2.06 |
Hydrophobic | ICL2 | V | 691 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | V | 691 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM4 | S | 698 | 4x28 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | I | 697 | - | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | I | 697 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | R | 695 | - | G.HN | R | 34 | G.HN.52 |
Van-der-waals | ICL2 | R | 695 | - | G.HN | R | 34 | G.HN.52 |
Ionic | C-term | E | 887 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | E | 887 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | E | 891 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | H8 | R | 861 | 8x55 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | H8 | R | 861 | 8x55 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | C-term | S | 874 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | C-term | S | 874 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | H8 | R | 861 | 8x55 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | H8 | F | 863 | 8x57 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 683 | 3x57 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | E | 887 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | A | 888 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | A | 888 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | TM3 | I | 680 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | F | 684 | 3x58 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | S | 881 | - | G.S2 | D | 195 | G.S2.07 |
Van-der-waals | C-term | S | 881 | - | G.S2 | D | 195 | G.S2.07 |
Polar | C-term | H | 878 | - | G.H1 | H | 63 | G.H1.12 |
Aromatic | C-term | H | 878 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | C-term | H | 878 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | H | 878 | - | G.H1 | H | 63 | G.H1.12 |
Polar | C-term | K | 889 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | K | 889 | - | G.S2 | E | 191 | G.S2.03 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 679 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | N | 885 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | N | 885 | - | G.H1 | H | 63 | G.H1.12 |
Ionic | H8 | R | 859 | 8x53 | G.h4s6 | D | 319 | G.h4s6.10 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | D | 319 | G.h4s6.10 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | D | 319 | G.h4s6.10 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | D | 319 | G.h4s6.10 |