Gs -
mGlu7 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 17.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | R | 385 | G.H5.17 |
Polar | H8 | Q | 857 | 8x51 | G.H5 | R | 389 | G.H5.21 |
Polar | TM4 | S | 698 | 4x28 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM4 | S | 698 | 4x28 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM4 | S | 698 | 4x28 | G.H5 | Y | 391 | G.H5.23 |
Ionic | C-term | K | 905 | - | H.HA | E | 87 | H.HA.03 |
Polar | C-term | K | 905 | - | H.HA | E | 87 | H.HA.03 |
Van-der-waals | C-term | K | 905 | - | H.HA | E | 87 | H.HA.03 |
Hydrophobic | ICL2 | S | 690 | - | G.S3 | V | 217 | G.S3.01 |
Polar | TM3 | F | 684 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | F | 684 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | F | 684 | 3x58 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | C-term | P | 898 | - | G.h1ha | E | 75 | G.h1ha.11 |
Van-der-waals | C-term | K | 864 | - | G.S6 | F | 363 | G.S6.05 |
Polar | ICL2 | A | 693 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | A | 693 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | A | 693 | - | G.H5 | H | 387 | G.H5.19 |
Polar | ICL1 | A | 623 | 12x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | R | 679 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | R | 38 | G.hns1.02 |
Aromatic | H8 | F | 863 | 8x57 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | H8 | F | 863 | 8x57 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | H8 | F | 863 | 8x57 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL1 | A | 623 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | ICL1 | A | 623 | 12x52 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | S | 900 | - | G.h1ha | E | 75 | G.h1ha.11 |
Hydrophobic | C-term | S | 900 | - | G.h1ha | E | 75 | G.h1ha.11 |
Van-der-waals | C-term | S | 900 | - | G.h1ha | E | 75 | G.h1ha.11 |
Hydrophobic | TM3 | F | 684 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | F | 684 | 3x58 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | N | 899 | - | G.h1ha | E | 75 | G.h1ha.11 |
Hydrophobic | TM3 | I | 683 | 3x57 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | K | 864 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | C-term | K | 864 | - | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | C-term | K | 864 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | TM6 | F | 784 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | F | 784 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | A | 351 | G.h4s6.04 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | A | 351 | G.h4s6.04 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | A | 351 | G.h4s6.04 |
Hydrophobic | H8 | F | 863 | 8x57 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | H8 | F | 863 | 8x57 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | G | 687 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | G | 687 | - | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | V | 691 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | V | 691 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | V | 691 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | I | 697 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | I | 697 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | K | 864 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | C-term | K | 864 | - | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | ICL2 | T | 692 | - | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | T | 692 | - | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | P | 694 | - | G.H5 | H | 387 | G.H5.19 |
Polar | H8 | F | 863 | 8x57 | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | TM4 | P | 699 | 4x29 | G.H5 | Y | 391 | G.H5.23 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | S | 352 | G.h4s6.08 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | ICL2 | V | 691 | - | G.S3 | V | 217 | G.S3.01 |
Ionic | ICL1 | R | 622 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Polar | ICL1 | R | 622 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL1 | R | 622 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | R | 622 | 12x51 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 861 | 8x55 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL2 | G | 687 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | K | 689 | - | G.S3 | V | 217 | G.S3.01 |
Polar | ICL2 | K | 688 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | K | 688 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | K | 688 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | H8 | F | 863 | 8x57 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM3 | R | 679 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 679 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 679 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Aromatic | H8 | F | 863 | 8x57 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | H8 | F | 863 | 8x57 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | H8 | F | 863 | 8x57 | G.S6 | Y | 360 | G.S6.02 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | H8 | S | 862 | 8x56 | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | H8 | S | 862 | 8x56 | G.H4 | L | 346 | G.H4.16 |
Polar | ICL1 | S | 624 | 12x53 | G.H5 | E | 392 | G.H5.24 |
Ionic | TM2 | R | 626 | 2x36 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | R | 626 | 2x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | R | 626 | 2x36 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | R | 626 | 2x36 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | V | 691 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | V | 691 | - | G.H5 | I | 383 | G.H5.15 |
Polar | H8 | R | 859 | 8x53 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | H8 | R | 859 | 8x53 | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | H8 | R | 859 | 8x53 | G.h4s6 | G | 353 | G.h4s6.09 |
Polar | TM2 | G | 625 | 2x35 | G.H5 | E | 392 | G.H5.24 |