G12 - mGlu8 receptor complex model

GPCR CLASS (FAMILY)

C (Glutamate)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 21.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term S 904 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 904 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM6 F 777 6x33 G.H5 L 380 G.H5.25
Van-der-waals TM6 F 777 6x33 G.H5 L 380 G.H5.25
Hydrophobic C-term S 904 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term I 901 - H.HA L 115 H.HA.29
Van-der-waals C-term I 901 - H.HA L 115 H.HA.29
Ionic H8 K 853 8x54 G.H5 D 377 G.H5.22
Polar H8 K 853 8x54 G.H5 D 377 G.H5.22
Hydrophobic H8 K 853 8x54 G.H5 D 377 G.H5.22
Van-der-waals H8 K 853 8x54 G.H5 D 377 G.H5.22
Hydrophobic C-term V 859 - G.H3 N 283 G.H3.15
Van-der-waals C-term V 859 - G.H3 N 283 G.H3.15
Hydrophobic TM3 I 673 3x54 G.H5 M 379 G.H5.24
Hydrophobic H8 K 853 8x54 G.h3s5 N 288 G.h3s5.02
Van-der-waals H8 K 853 8x54 G.h3s5 N 288 G.h3s5.02
Hydrophobic C-term V 859 - G.H3 K 284 G.H3.16
Van-der-waals C-term V 859 - G.H3 K 284 G.H3.16
Polar ICL2 T 685 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 685 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 685 - G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 676 3x57 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 676 3x57 G.H5 L 375 G.H5.20
Hydrophobic ICL3 P 774 - G.H5 Q 372 G.H5.17
Polar C-term Y 900 - H.hdhe Q 174 H.hdhe.02
Hydrophobic C-term Y 900 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term Y 900 - H.hdhe Q 174 H.hdhe.02
Hydrophobic H8 R 854 8x55 G.H3 K 284 G.H3.16
Van-der-waals H8 R 854 8x55 G.H3 K 284 G.H3.16
Hydrophobic ICL2 V 684 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 V 684 - G.S1 V 58 G.S1.02
Polar ICL2 S 683 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 S 683 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 S 683 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 K 682 - G.s2s3 K 219 G.s2s3.01
Van-der-waals ICL2 K 682 - G.s2s3 K 219 G.s2s3.01
Van-der-waals C-term T 898 - H.HD R 169 H.HD.09
Hydrophobic C-term Y 900 - H.HD E 172 H.HD.12
Van-der-waals C-term Y 900 - H.HD E 172 H.HD.12
Polar ICL2 A 686 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 A 686 - G.hns1 R 56 G.hns1.03
Polar C-term I 901 - H.HD E 172 H.HD.12
Van-der-waals C-term I 901 - H.HD E 172 H.HD.12
Hydrophobic TM3 I 676 3x57 G.H5 M 379 G.H5.24
Hydrophobic ICL1 A 616 12x52 G.H5 L 380 G.H5.25
Van-der-waals ICL1 A 616 12x52 G.H5 L 380 G.H5.25
Hydrophobic C-term N 905 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term N 905 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term I 908 - H.HA R 106 H.HA.20
Van-der-waals C-term I 908 - H.HA R 106 H.HA.20
Hydrophobic C-term Y 900 - G.s4h3 V 260 G.s4h3.07
Van-der-waals C-term Y 900 - G.s4h3 V 260 G.s4h3.07
Hydrophobic ICL2 G 680 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 G 680 - G.H5 L 371 G.H5.16
Hydrophobic TM3 F 677 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 A 686 - G.H5 I 378 G.H5.23
Hydrophobic H8 F 856 8x57 G.h2s4 D 243 G.h2s4.02
Van-der-waals H8 F 856 8x57 G.h2s4 D 243 G.h2s4.02
Hydrophobic ICL2 V 684 - G.H5 L 371 G.H5.16
Van-der-waals ICL2 V 684 - G.H5 L 371 G.H5.16
Polar ICL3 T 776 - G.H5 K 376 G.H5.21
Hydrophobic ICL3 T 776 - G.H5 K 376 G.H5.21
Van-der-waals ICL3 T 776 - G.H5 K 376 G.H5.21
Van-der-waals ICL1 A 616 12x52 G.H5 M 379 G.H5.24
Hydrophobic H8 F 856 8x57 G.h2s4 F 242 G.h2s4.01
Van-der-waals H8 F 856 8x57 G.h2s4 F 242 G.h2s4.01
Hydrophobic TM6 F 777 6x33 G.H5 K 376 G.H5.21
Van-der-waals TM6 F 777 6x33 G.H5 K 376 G.H5.21
Hydrophobic H8 R 852 8x53 G.h3s5 F 287 G.h3s5.01
Van-der-waals H8 R 852 8x53 G.h3s5 F 287 G.h3s5.01
Polar C-term Y 900 - H.HD S 171 H.HD.11
Hydrophobic C-term Y 900 - H.HD S 171 H.HD.11
Van-der-waals C-term Y 900 - H.HD S 171 H.HD.11
Polar C-term Y 903 - H.HA D 110 H.HA.24
Hydrophobic C-term Y 903 - H.HA D 110 H.HA.24
Van-der-waals C-term Y 903 - H.HA D 110 H.HA.24
Hydrophobic ICL2 S 683 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 S 683 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 V 684 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 V 684 - G.S3 I 221 G.S3.01
Polar C-term Y 903 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Y 903 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Y 903 - G.s4h3 R 265 G.s4h3.12
Hydrophobic H8 F 856 8x57 G.H3 L 285 G.H3.17
Van-der-waals H8 F 856 8x57 G.H3 L 285 G.H3.17
Hydrophobic ICL2 K 681 - G.H5 L 371 G.H5.16
Polar ICL2 K 682 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL2 K 682 - G.s2s3 K 220 G.s2s3.02
Van-der-waals ICL2 K 682 - G.s2s3 K 220 G.s2s3.02
Hydrophobic ICL3 P 774 - G.H5 K 376 G.H5.21
Hydrophobic C-term T 898 - H.HD E 172 H.HD.12
Van-der-waals C-term T 898 - H.HD E 172 H.HD.12
Hydrophobic C-term Y 903 - G.s4h3 M 262 G.s4h3.09
Van-der-waals C-term Y 903 - G.s4h3 M 262 G.s4h3.09
Hydrophobic C-term I 901 - H.HA A 111 H.HA.25
Hydrophobic C-term V 860 - G.H3 L 285 G.H3.17
Polar C-term Y 903 - H.HA V 107 H.HA.21
Hydrophobic C-term Y 903 - H.HA V 107 H.HA.21
Van-der-waals C-term Y 903 - H.HA V 107 H.HA.21
Hydrophobic ICL2 V 684 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 684 - G.hns1 R 56 G.hns1.03
Hydrophobic TM6 F 777 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 777 6x33 G.H5 M 379 G.H5.24
Hydrophobic ICL2 T 685 - G.S3 P 222 G.S3.02
Polar TM3 R 672 3x53 G.H5 Q 381 G.H5.26
Van-der-waals TM3 R 672 3x53 G.H5 Q 381 G.H5.26
Hydrophobic C-term Y 900 - G.s4h3 R 265 G.s4h3.12
Hydrophobic ICL2 V 684 - G.S1 L 57 G.S1.01
Polar ICL2 K 682 - G.S3 I 221 G.S3.01
Hydrophobic ICL2 K 682 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 K 682 - G.S3 I 221 G.S3.01
Polar C-term Y 903 - H.HA A 111 H.HA.25
Hydrophobic C-term Y 903 - H.HA A 111 H.HA.25
Van-der-waals C-term Y 903 - H.HA A 111 H.HA.25
Hydrophobic H8 K 851 8x52 G.h3s5 F 287 G.h3s5.01
Hydrophobic C-term I 901 - H.HA K 114 H.HA.28
Van-der-waals C-term I 901 - H.HA K 114 H.HA.28
Hydrophobic TM3 I 676 3x57 G.H5 I 378 G.H5.23
Polar C-term Y 900 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term Y 900 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term Y 900 - H.hdhe F 173 H.hdhe.01
Polar C-term S 902 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term S 902 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term S 902 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term Y 903 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term Y 903 - H.hdhe F 173 H.hdhe.01
Hydrophobic C-term V 859 - G.H3 L 285 G.H3.17
Van-der-waals C-term V 859 - G.H3 L 285 G.H3.17
Hydrophobic ICL2 G 680 - G.H5 L 375 G.H5.20
Van-der-waals ICL2 G 680 - G.H5 L 375 G.H5.20
Hydrophobic ICL2 K 681 - G.S3 I 221 G.S3.01
Hydrophobic C-term I 901 - H.hdhe F 173 H.hdhe.01
Van-der-waals C-term I 901 - H.hdhe F 173 H.hdhe.01