G15 -
mGlu8 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | K | 681 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | K | 681 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | K | 681 | - | G.H5 | R | 360 | G.H5.12 |
Polar | C-term | Y | 903 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | Y | 903 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | Y | 903 | - | G.S2 | C | 196 | G.S2.05 |
Ionic | C-term | E | 884 | - | G.H2 | R | 216 | G.H2.04 |
Polar | C-term | E | 884 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | E | 884 | - | G.H2 | R | 216 | G.H2.04 |
Polar | C-term | Y | 900 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | Y | 900 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | Y | 900 | - | G.S2 | E | 194 | G.S2.03 |
Ionic | C-term | E | 880 | - | G.H2 | K | 213 | G.H2.01 |
Polar | C-term | E | 880 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | E | 880 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | TM3 | R | 672 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 672 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | L | 889 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | I | 676 | 3x57 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | A | 863 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | A | 863 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | H8 | F | 856 | 8x57 | G.H3 | W | 266 | G.H3.17 |
Polar | C-term | S | 904 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | ICL3 | T | 776 | - | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | V | 881 | - | G.H3 | E | 253 | G.H3.04 |
Van-der-waals | C-term | V | 881 | - | G.H3 | E | 253 | G.H3.04 |
Hydrophobic | ICL1 | A | 616 | 12x52 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | ICL1 | A | 616 | 12x52 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | T | 899 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | T | 899 | - | G.S2 | E | 194 | G.S2.03 |
Polar | ICL2 | V | 684 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | T | 898 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | T | 898 | - | G.S2 | I | 192 | G.S2.01 |
Polar | C-term | T | 899 | - | G.S2 | N | 193 | G.S2.02 |
Hydrophobic | C-term | T | 899 | - | G.S2 | N | 193 | G.S2.02 |
Van-der-waals | C-term | T | 899 | - | G.S2 | N | 193 | G.S2.02 |
Polar | C-term | Y | 903 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | C-term | Y | 903 | - | G.H1 | R | 63 | G.H1.09 |
Van-der-waals | C-term | Y | 903 | - | G.H1 | R | 63 | G.H1.09 |
Hydrophobic | ICL2 | V | 684 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | I | 901 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | I | 901 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | TM3 | I | 673 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | I | 673 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | H8 | K | 851 | 8x52 | G.h4s6 | G | 333 | G.h4s6.15 |
Hydrophobic | H8 | K | 851 | 8x52 | G.h4s6 | G | 333 | G.h4s6.15 |
Van-der-waals | H8 | K | 851 | 8x52 | G.h4s6 | G | 333 | G.h4s6.15 |
Hydrophobic | ICL2 | T | 685 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | N | 878 | - | G.H3 | A | 256 | G.H3.07 |
Polar | C-term | I | 901 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | I | 901 | - | G.S2 | E | 194 | G.S2.03 |
Polar | ICL2 | A | 686 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | A | 686 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | A | 686 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | C-term | Y | 903 | - | G.S2 | F | 197 | G.S2.06 |
Van-der-waals | C-term | Y | 903 | - | G.S2 | F | 197 | G.S2.06 |
Hydrophobic | ICL2 | V | 684 | - | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 684 | - | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | F | 777 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | V | 881 | - | G.H3 | T | 260 | G.H3.11 |
Polar | C-term | N | 905 | - | G.H1 | H | 66 | G.H1.12 |
Hydrophobic | C-term | V | 881 | - | G.H3 | L | 257 | G.H3.08 |
Van-der-waals | C-term | V | 881 | - | G.H3 | L | 257 | G.H3.08 |
Polar | H8 | K | 851 | 8x52 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | H8 | K | 851 | 8x52 | G.h4s6 | K | 331 | G.h4s6.13 |
Van-der-waals | H8 | K | 851 | 8x52 | G.h4s6 | K | 331 | G.h4s6.13 |
Hydrophobic | C-term | L | 885 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | C-term | L | 885 | - | G.H3 | L | 257 | G.H3.08 |
Polar | ICL1 | R | 615 | 12x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL1 | R | 615 | 12x51 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | ICL1 | R | 615 | 12x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | C-term | T | 896 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | L | 889 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | L | 889 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | ICL2 | T | 685 | - | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | C-term | S | 902 | - | G.S2 | C | 196 | G.S2.05 |
Hydrophobic | C-term | L | 885 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM3 | F | 677 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | F | 677 | 3x58 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | V | 859 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | V | 859 | - | G.H3 | P | 265 | G.H3.16 |
Polar | ICL2 | V | 684 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | V | 684 | - | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | V | 684 | - | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | C-term | T | 896 | - | G.H2 | K | 218 | G.H2.06 |
Polar | C-term | S | 888 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | S | 888 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | S | 888 | - | G.H2 | K | 217 | G.H2.05 |
Polar | C-term | T | 896 | - | G.H2 | H | 221 | G.H2.09 |
Hydrophobic | C-term | T | 896 | - | G.H2 | H | 221 | G.H2.09 |
Van-der-waals | C-term | T | 896 | - | G.H2 | H | 221 | G.H2.09 |
Ionic | C-term | E | 887 | - | G.H2 | K | 217 | G.H2.05 |
Polar | C-term | E | 887 | - | G.H2 | K | 217 | G.H2.05 |
Van-der-waals | C-term | E | 887 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | Y | 903 | - | G.S2 | Y | 195 | G.S2.04 |
Van-der-waals | C-term | Y | 903 | - | G.S2 | Y | 195 | G.S2.04 |
Hydrophobic | ICL2 | V | 684 | - | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | V | 684 | - | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 676 | 3x57 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | F | 777 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Polar | ICL3 | T | 776 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | T | 776 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | K | 669 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | N | 905 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | N | 905 | - | G.h1ha | G | 67 | G.h1ha.01 |
Van-der-waals | C-term | N | 905 | - | G.h1ha | G | 67 | G.h1ha.01 |
Hydrophobic | C-term | E | 884 | - | G.H2 | K | 213 | G.H2.01 |
Van-der-waals | C-term | E | 884 | - | G.H2 | K | 213 | G.H2.01 |
Hydrophobic | ICL2 | V | 684 | - | G.H5 | F | 356 | G.H5.08 |
Hydrophobic | H8 | K | 851 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | K | 851 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM6 | E | 779 | 6x35 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | E | 779 | 6x35 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | N | 905 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | N | 905 | - | G.h1ha | A | 68 | G.h1ha.02 |
Van-der-waals | C-term | N | 905 | - | G.h1ha | A | 68 | G.h1ha.02 |
Hydrophobic | C-term | K | 882 | - | G.H3 | T | 260 | G.H3.11 |
Van-der-waals | C-term | K | 882 | - | G.H3 | T | 260 | G.H3.11 |
Polar | ICL2 | G | 680 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | G | 680 | - | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | G | 680 | - | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | C-term | L | 885 | - | G.H2 | W | 219 | G.H2.07 |
Hydrophobic | C-term | S | 888 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | N | 892 | - | G.H2 | H | 221 | G.H2.09 |
Polar | C-term | I | 901 | - | G.S2 | C | 196 | G.S2.05 |
Van-der-waals | C-term | I | 901 | - | G.S2 | C | 196 | G.S2.05 |
Polar | ICL1 | A | 616 | 12x52 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | T | 899 | - | G.S2 | I | 192 | G.S2.01 |
Van-der-waals | C-term | T | 899 | - | G.S2 | I | 192 | G.S2.01 |
Hydrophobic | C-term | T | 898 | - | G.S2 | E | 194 | G.S2.03 |
Van-der-waals | C-term | T | 898 | - | G.S2 | E | 194 | G.S2.03 |
Hydrophobic | C-term | L | 885 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | A | 365 | G.H5.17 |
Polar | C-term | Y | 900 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | C-term | Y | 900 | - | G.S3 | R | 205 | G.S3.04 |
Van-der-waals | C-term | Y | 900 | - | G.S3 | R | 205 | G.S3.04 |
Hydrophobic | C-term | Y | 903 | - | G.h1ha | G | 67 | G.h1ha.01 |
Ionic | C-term | K | 882 | - | G.H3 | E | 263 | G.H3.14 |
Polar | C-term | K | 882 | - | G.H3 | E | 263 | G.H3.14 |
Hydrophobic | C-term | K | 882 | - | G.H3 | E | 263 | G.H3.14 |
Van-der-waals | C-term | K | 882 | - | G.H3 | E | 263 | G.H3.14 |
Hydrophobic | ICL2 | G | 680 | - | G.H5 | L | 364 | G.H5.16 |