Gt1 -
mGlu8 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | ICL2 | K | 682 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Polar | ICL2 | K | 682 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 682 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 682 | - | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | H8 | F | 856 | 8x57 | G.h2s4 | T | 215 | G.h2s4.05 |
Van-der-waals | H8 | F | 856 | 8x57 | G.h2s4 | T | 215 | G.h2s4.05 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Polar | C-term | K | 857 | - | G.H5 | N | 343 | G.H5.19 |
Polar | H8 | R | 852 | 8x53 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | H8 | R | 852 | 8x53 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | H8 | R | 852 | 8x53 | G.h4s6 | D | 311 | G.h4s6.09 |
Ionic | C-term | E | 890 | - | G.H2 | K | 205 | G.H2.05 |
Polar | C-term | E | 890 | - | G.H2 | K | 205 | G.H2.05 |
Hydrophobic | C-term | E | 890 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | C-term | E | 890 | - | G.H2 | K | 205 | G.H2.05 |
Van-der-waals | ICL2 | K | 681 | - | G.s2s3 | K | 188 | G.s2s3.01 |
Polar | H8 | K | 853 | 8x54 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | H8 | K | 853 | 8x54 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | H8 | K | 853 | 8x54 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | H8 | K | 853 | 8x54 | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | C-term | L | 889 | - | G.H3 | S | 248 | G.H3.11 |
Hydrophobic | ICL2 | K | 681 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | K | 681 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | C-term | V | 859 | - | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | C-term | C | 886 | - | G.H2 | K | 205 | G.H2.05 |
Polar | ICL1 | A | 616 | 12x52 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | ICL1 | A | 616 | 12x52 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | ICL1 | A | 616 | 12x52 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | I | 676 | 3x57 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | TM2 | G | 618 | 2x35 | G.H5 | L | 349 | G.H5.25 |
Ionic | C-term | E | 884 | - | G.H3 | R | 253 | G.H3.16 |
Polar | C-term | E | 884 | - | G.H3 | R | 253 | G.H3.16 |
Hydrophobic | C-term | E | 884 | - | G.H3 | R | 253 | G.H3.16 |
Van-der-waals | C-term | E | 884 | - | G.H3 | R | 253 | G.H3.16 |
Polar | H8 | S | 855 | 8x56 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | H8 | S | 855 | 8x56 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | G | 680 | - | G.H5 | I | 339 | G.H5.15 |
Van-der-waals | ICL2 | G | 680 | - | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | C-term | L | 885 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | H8 | R | 854 | 8x55 | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | H8 | R | 854 | 8x55 | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | C-term | L | 885 | - | G.H3 | H | 252 | G.H3.15 |
Van-der-waals | C-term | L | 885 | - | G.H3 | H | 252 | G.H3.15 |
Polar | H8 | R | 852 | 8x53 | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | H8 | R | 852 | 8x53 | G.h4s6 | V | 312 | G.h4s6.10 |
Van-der-waals | H8 | R | 852 | 8x53 | G.h4s6 | V | 312 | G.h4s6.10 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM6 | F | 777 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Polar | ICL2 | V | 684 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | V | 684 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | V | 684 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM6 | F | 777 | 6x33 | G.H5 | K | 341 | G.H5.17 |
Van-der-waals | TM6 | F | 777 | 6x33 | G.H5 | K | 341 | G.H5.17 |
Hydrophobic | ICL2 | G | 680 | - | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | ICL2 | I | 690 | - | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | ICL2 | I | 690 | - | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL1 | A | 616 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | ICL1 | A | 616 | 12x52 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL1 | A | 616 | 12x52 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | ICL2 | S | 683 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | H8 | K | 851 | 8x52 | G.h4s6 | D | 311 | G.h4s6.09 |
Van-der-waals | H8 | K | 851 | 8x52 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | ICL2 | K | 682 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | K | 682 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL1 | R | 615 | 12x51 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM3 | I | 673 | 3x54 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL3 | P | 774 | - | G.H5 | D | 337 | G.H5.13 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | I | 676 | 3x57 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | V | 684 | - | G.S1 | V | 30 | G.S1.02 |
Van-der-waals | ICL2 | V | 684 | - | G.S1 | V | 30 | G.S1.02 |
Hydrophobic | ICL2 | T | 685 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | S | 855 | 8x56 | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | ICL2 | V | 684 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | H8 | F | 856 | 8x57 | G.H5 | E | 342 | G.H5.18 |
Van-der-waals | H8 | F | 856 | 8x57 | G.H5 | E | 342 | G.H5.18 |
Polar | ICL2 | T | 685 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | ICL2 | T | 685 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | T | 685 | - | G.hns1 | A | 27 | G.hns1.02 |
Ionic | C-term | K | 857 | - | G.H5 | D | 346 | G.H5.22 |
Polar | C-term | K | 857 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | C-term | K | 857 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | C-term | K | 857 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | C-term | Y | 903 | - | G.hgh4 | P | 284 | G.hgh4.03 |
Polar | TM3 | R | 672 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | R | 672 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 672 | 3x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL2 | V | 684 | - | G.h2s4 | T | 215 | G.h2s4.05 |
Hydrophobic | C-term | L | 885 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Van-der-waals | C-term | L | 885 | - | G.h2s4 | F | 211 | G.h2s4.01 |
Hydrophobic | ICL2 | V | 684 | - | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM3 | I | 676 | 3x57 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | I | 676 | 3x57 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | H8 | F | 856 | 8x57 | G.h3s5 | T | 258 | G.h3s5.03 |
Van-der-waals | H8 | F | 856 | 8x57 | G.h3s5 | T | 258 | G.h3s5.03 |
Hydrophobic | ICL2 | V | 684 | - | G.hns1 | R | 28 | G.hns1.03 |
Hydrophobic | H8 | R | 854 | 8x55 | G.h4s6 | R | 309 | G.h4s6.04 |
Hydrophobic | ICL2 | S | 683 | - | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | S | 683 | - | G.S3 | L | 190 | G.S3.01 |
Hydrophobic | ICL2 | K | 681 | - | G.H5 | T | 336 | G.H5.12 |
Hydrophobic | C-term | S | 883 | - | G.H2 | I | 208 | G.H2.08 |
Van-der-waals | C-term | S | 883 | - | G.H2 | I | 208 | G.H2.08 |
Hydrophobic | H8 | R | 854 | 8x55 | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | H8 | R | 854 | 8x55 | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | ICL2 | S | 683 | - | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL3 | T | 776 | - | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | ICL3 | T | 776 | - | G.H5 | F | 350 | G.H5.26 |
Polar | ICL2 | S | 683 | - | G.hns1 | A | 27 | G.hns1.02 |
Van-der-waals | ICL2 | S | 683 | - | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | H8 | F | 856 | 8x57 | G.h2s4 | V | 214 | G.h2s4.04 |
Van-der-waals | H8 | F | 856 | 8x57 | G.h2s4 | V | 214 | G.h2s4.04 |
Hydrophobic | C-term | L | 885 | - | G.H3 | Y | 254 | G.H3.17 |
Hydrophobic | ICL1 | S | 617 | 12x53 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | H8 | F | 856 | 8x57 | G.h3s5 | T | 257 | G.h3s5.02 |
Van-der-waals | H8 | F | 856 | 8x57 | G.h3s5 | T | 257 | G.h3s5.02 |
Hydrophobic | C-term | A | 863 | - | G.h2s4 | E | 212 | G.h2s4.02 |
Hydrophobic | TM3 | F | 677 | 3x58 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | TM3 | F | 677 | 3x58 | G.H5 | I | 340 | G.H5.16 |
Polar | ICL2 | V | 684 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | V | 684 | - | G.H5 | N | 343 | G.H5.19 |
Polar | C-term | Y | 900 | - | G.H3 | H | 240 | G.H3.03 |
Aromatic | C-term | Y | 900 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | C-term | Y | 900 | - | G.H3 | H | 240 | G.H3.03 |
Van-der-waals | C-term | Y | 900 | - | G.H3 | H | 240 | G.H3.03 |
Hydrophobic | ICL2 | V | 684 | - | G.S1 | T | 29 | G.S1.01 |
Van-der-waals | ICL2 | V | 684 | - | G.S1 | T | 29 | G.S1.01 |
Polar | ICL2 | A | 686 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | A | 686 | - | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | A | 686 | - | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | R | 672 | 3x53 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 672 | 3x53 | G.H5 | L | 349 | G.H5.25 |