Gs -
HCA1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | F | 285 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | F | 285 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | T | 126 | 34x56 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL2 | I | 127 | 34x57 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM3 | V | 117 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 117 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 117 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | R | 206 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | R | 206 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL3 | R | 206 | - | G.H5 | R | 380 | G.H5.12 |
Polar | TM6 | Q | 212 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | Q | 212 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | Q | 212 | 6x27 | G.H5 | R | 385 | G.H5.17 |
Polar | TM3 | V | 118 | 3x55 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | L | 203 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | M | 215 | 6x30 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | M | 215 | 6x30 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 120 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 120 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM6 | M | 215 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | M | 215 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Polar | TM6 | A | 218 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | A | 218 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | A | 218 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM4 | R | 130 | 4x40 | G.HN | Q | 31 | G.HN.48 |
Van-der-waals | TM4 | R | 130 | 4x40 | G.HN | Q | 31 | G.HN.48 |
Polar | TM4 | S | 128 | 4x38 | G.HN | Q | 31 | G.HN.48 |
Hydrophobic | TM2 | S | 50 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | S | 50 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | H | 121 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | H | 121 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Polar | H8 | P | 283 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | P | 283 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | P | 283 | 8x48 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM3 | R | 113 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | H8 | S | 284 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 284 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 284 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | R | 214 | 6x29 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM6 | Q | 212 | 6x27 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM6 | Q | 212 | 6x27 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 212 | 6x27 | G.h4s6 | Y | 358 | G.h4s6.20 |
Polar | TM3 | D | 112 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 112 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 112 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Ionic | TM4 | R | 130 | 4x40 | G.HN | E | 27 | G.HN.44 |
Polar | TM4 | R | 130 | 4x40 | G.HN | E | 27 | G.HN.44 |
Aromatic | ICL2 | H | 121 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | H | 121 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Polar | H8 | S | 282 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 282 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 282 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | R | 214 | 6x29 | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM6 | R | 214 | 6x29 | G.h4s6 | G | 355 | G.h4s6.11 |
Van-der-waals | TM6 | R | 214 | 6x29 | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | TM3 | R | 113 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | K | 116 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Aromatic | TM3 | K | 116 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | K | 116 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | K | 116 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | T | 126 | 34x56 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | H8 | P | 283 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | P | 283 | 8x48 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | H | 121 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Aromatic | ICL2 | H | 121 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | H | 121 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | H | 121 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | H | 121 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | L | 209 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | ICL3 | L | 209 | - | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM3 | V | 117 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | V | 117 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | R | 214 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | R | 214 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | I | 222 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Polar | TM2 | K | 48 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM2 | K | 48 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | K | 48 | 2x37 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | TM6 | A | 218 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Polar | TM3 | K | 116 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | K | 116 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | K | 116 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | H | 121 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | H | 121 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL2 | P | 120 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 120 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | L | 209 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | L | 209 | - | G.H5 | R | 385 | G.H5.17 |
Polar | ICL3 | R | 206 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL3 | R | 206 | - | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL3 | R | 206 | - | G.H5 | Q | 384 | G.H5.16 |
Polar | TM6 | R | 214 | 6x29 | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | TM6 | R | 214 | 6x29 | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | ICL2 | P | 120 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | P | 120 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM6 | F | 221 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | F | 221 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | M | 215 | 6x30 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM6 | M | 215 | 6x30 | G.H5 | L | 388 | G.H5.20 |