Gt1 - HCA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 P 132 34x50 G.H5 N 343 G.H5.19
Hydrophobic C-term L 382 - G.H2 I 208 G.H2.08
Hydrophobic C-term L 382 - G.h2s4 F 211 G.h2s4.01
Hydrophobic TM6 A 229 6x33 G.H5 L 349 G.H5.25
Hydrophobic H8 P 299 8x48 G.H5 F 350 G.H5.26
Van-der-waals H8 P 299 8x48 G.H5 F 350 G.H5.26
Ionic TM3 R 128 3x53 G.H5 D 346 G.H5.22
Polar TM3 R 128 3x53 G.H5 D 346 G.H5.22
Polar C-term C 385 - G.H3 S 248 G.H3.11
Hydrophobic C-term C 385 - G.H3 S 248 G.H3.11
Van-der-waals C-term C 385 - G.H3 S 248 G.H3.11
Polar H8 S 298 8x47 G.H5 G 348 G.H5.24
Hydrophobic H8 S 298 8x47 G.H5 G 348 G.H5.24
Van-der-waals H8 S 298 8x47 G.H5 G 348 G.H5.24
Polar TM3 R 128 3x53 G.H5 N 343 G.H5.19
Hydrophobic TM3 R 128 3x53 G.H5 N 343 G.H5.19
Van-der-waals TM3 R 128 3x53 G.H5 N 343 G.H5.19
Hydrophobic C-term I 386 - G.H3 L 245 G.H3.08
Van-der-waals C-term I 386 - G.H3 L 245 G.H3.08
Hydrophobic C-term I 386 - G.H2 W 207 G.H2.07
Hydrophobic C-term L 378 - G.H2 I 208 G.H2.08
Van-der-waals C-term L 378 - G.H2 I 208 G.H2.08
Hydrophobic C-term I 386 - G.H2 R 204 G.H2.04
Ionic C-term E 379 - G.H2 K 205 G.H2.05
Polar C-term E 379 - G.H2 K 205 G.H2.05
Hydrophobic C-term E 379 - G.H2 K 205 G.H2.05
Van-der-waals C-term E 379 - G.H2 K 205 G.H2.05
Hydrophobic ICL2 H 133 34x51 G.S3 L 190 G.S3.01
Van-der-waals ICL2 H 133 34x51 G.S3 L 190 G.S3.01
Hydrophobic C-term C 385 - G.H3 H 252 G.H3.15
Van-der-waals C-term C 385 - G.H3 H 252 G.H3.15
Hydrophobic TM3 V 129 3x54 G.H5 L 344 G.H5.20
Van-der-waals TM3 V 129 3x54 G.H5 L 344 G.H5.20
Ionic TM2 K 60 2x37 G.H5 D 346 G.H5.22
Polar TM2 K 60 2x37 G.H5 D 346 G.H5.22
Hydrophobic TM2 K 60 2x37 G.H5 D 346 G.H5.22
Van-der-waals TM2 K 60 2x37 G.H5 D 346 G.H5.22
Hydrophobic TM6 I 233 6x37 G.H5 L 349 G.H5.25
Hydrophobic ICL2 H 133 34x51 G.H5 I 339 G.H5.15
Van-der-waals ICL2 H 133 34x51 G.H5 I 339 G.H5.15
Hydrophobic TM6 I 226 6x30 G.H5 L 344 G.H5.20
Polar C-term E 387 - G.H3 H 244 G.H3.07
Hydrophobic C-term E 387 - G.H3 H 244 G.H3.07
Van-der-waals C-term E 387 - G.H3 H 244 G.H3.07
Hydrophobic TM6 I 226 6x30 G.H5 F 350 G.H5.26
Hydrophobic TM5 L 215 5x65 G.H5 I 340 G.H5.16
Hydrophobic TM3 R 125 3x50 G.H5 L 349 G.H5.25
Ionic ICL3 H 223 - G.h4s6 E 314 G.h4s6.12
Polar ICL3 H 223 - G.h4s6 E 314 G.h4s6.12
Hydrophobic ICL3 H 223 - G.h4s6 E 314 G.h4s6.12
Van-der-waals ICL3 H 223 - G.h4s6 E 314 G.h4s6.12
Hydrophobic ICL3 M 220 - G.H5 K 341 G.H5.17
Polar C-term I 386 - G.H3 S 248 G.H3.11
Hydrophobic C-term I 386 - G.H3 S 248 G.H3.11
Van-der-waals C-term I 386 - G.H3 S 248 G.H3.11
Hydrophobic ICL2 P 132 34x50 G.H5 T 336 G.H5.12
Van-der-waals ICL2 P 132 34x50 G.H5 T 336 G.H5.12
Hydrophobic ICL3 M 220 - G.H5 D 337 G.H5.13
Van-der-waals ICL3 M 220 - G.H5 D 337 G.H5.13
Hydrophobic ICL3 M 220 - G.H5 I 340 G.H5.16
Polar ICL2 K 138 34x56 G.hns1 A 27 G.hns1.02
Hydrophobic ICL2 K 138 34x56 G.hns1 A 27 G.hns1.02
Van-der-waals ICL2 K 138 34x56 G.hns1 A 27 G.hns1.02
Aromatic ICL2 H 133 34x51 G.H5 F 332 G.H5.08
Hydrophobic ICL2 H 133 34x51 G.H5 F 332 G.H5.08
Van-der-waals ICL2 H 133 34x51 G.H5 F 332 G.H5.08
Hydrophobic C-term I 386 - G.H3 H 244 G.H3.07
Polar TM3 D 124 3x49 G.H5 C 347 G.H5.23
Hydrophobic TM3 V 129 3x54 G.H5 I 340 G.H5.16
Van-der-waals TM3 V 129 3x54 G.H5 I 340 G.H5.16
Polar ICL2 H 133 34x51 G.H5 T 336 G.H5.12
Hydrophobic ICL2 H 133 34x51 G.H5 T 336 G.H5.12
Van-der-waals ICL2 H 133 34x51 G.H5 T 336 G.H5.12
Ionic TM5 R 218 5x68 G.H5 D 333 G.H5.09
Polar TM5 R 218 5x68 G.H5 D 333 G.H5.09
Van-der-waals TM5 R 218 5x68 G.H5 D 333 G.H5.09
Ionic TM5 R 218 5x68 G.H5 D 337 G.H5.13
Polar TM5 R 218 5x68 G.H5 D 337 G.H5.13
Hydrophobic TM5 R 218 5x68 G.H5 D 337 G.H5.13
Van-der-waals TM5 R 218 5x68 G.H5 D 337 G.H5.13
Polar TM4 S 140 4x38 G.HN K 20 G.HN.48
Hydrophobic TM4 S 140 4x38 G.HN K 20 G.HN.48
Van-der-waals TM4 S 140 4x38 G.HN K 20 G.HN.48
Polar ICL3 H 223 - G.H5 K 341 G.H5.17
Aromatic ICL3 H 223 - G.H5 K 341 G.H5.17
Hydrophobic ICL3 H 223 - G.H5 K 341 G.H5.17
Hydrophobic TM5 R 218 5x68 G.H5 I 340 G.H5.16
Van-der-waals TM5 R 218 5x68 G.H5 I 340 G.H5.16
Hydrophobic TM6 I 226 6x30 G.H5 K 341 G.H5.17
Hydrophobic TM6 A 229 6x33 G.H5 L 344 G.H5.20
Polar H8 S 300 8x49 G.H5 K 345 G.H5.21
Hydrophobic ICL2 P 132 34x50 G.H5 I 340 G.H5.16
Hydrophobic H8 P 299 8x48 G.H5 L 349 G.H5.25
Hydrophobic ICL2 P 132 34x50 G.H5 I 339 G.H5.15
Hydrophobic TM3 R 128 3x53 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 128 3x53 G.H5 C 347 G.H5.23
Hydrophobic C-term L 382 - G.H3 H 252 G.H3.15
Polar H8 P 299 8x48 G.H5 G 348 G.H5.24
Hydrophobic H8 P 299 8x48 G.H5 G 348 G.H5.24
Van-der-waals H8 P 299 8x48 G.H5 G 348 G.H5.24
Hydrophobic TM6 F 232 6x36 G.H5 L 349 G.H5.25
Van-der-waals TM6 F 232 6x36 G.H5 L 349 G.H5.25
Van-der-waals ICL2 K 138 34x56 G.hns1 R 28 G.hns1.03
Hydrophobic C-term L 378 - G.H2 K 205 G.H2.05
Van-der-waals C-term L 378 - G.H2 K 205 G.H2.05
Polar TM3 R 125 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM3 R 125 3x50 G.H5 C 347 G.H5.23
Van-der-waals TM3 R 125 3x50 G.H5 C 347 G.H5.23
Hydrophobic TM5 R 218 5x68 G.H5 T 336 G.H5.12
Van-der-waals TM5 R 218 5x68 G.H5 T 336 G.H5.12
Hydrophobic TM5 L 215 5x65 G.H5 L 344 G.H5.20
Hydrophobic TM6 K 225 6x29 G.H5 F 350 G.H5.26
Van-der-waals TM6 K 225 6x29 G.H5 F 350 G.H5.26