G12 - H2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 85.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 V 120 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 120 3x54 G.H5 L 371 G.H5.16
Polar ICL2 P 127 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 127 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 127 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM7 L 291 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 L 291 7x56 G.H5 L 380 G.H5.25
Hydrophobic ICL2 L 124 34x51 G.H5 K 367 G.H5.12
Polar H8 R 293 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 R 293 8x48 G.H5 L 380 G.H5.25
Hydrophobic C-term L 340 - G.HG K 311 G.HG.16
Van-der-waals C-term L 340 - G.HG K 311 G.HG.16
Polar C-term K 338 - G.hgh4 R 318 G.hgh4.06
Hydrophobic C-term K 338 - G.hgh4 R 318 G.hgh4.06
Hydrophobic ICL2 P 123 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 235 6x36 G.H5 L 380 G.H5.25
Hydrophobic C-term K 341 - G.hgh4 G 319 G.hgh4.07
Van-der-waals C-term K 341 - G.hgh4 G 319 G.hgh4.07
Hydrophobic TM3 V 120 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 120 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 123 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 123 34x50 G.H5 I 370 G.H5.15
Polar C-term K 341 - G.hgh4 R 318 G.hgh4.06
Hydrophobic C-term K 341 - G.hgh4 R 318 G.hgh4.06
Van-der-waals C-term K 341 - G.hgh4 R 318 G.hgh4.06
Hydrophobic TM5 I 205 5x61 G.H5 I 378 G.H5.23
Hydrophobic C-term P 339 - G.hgh4 F 317 G.hgh4.05
Van-der-waals C-term P 339 - G.hgh4 F 317 G.hgh4.05
Hydrophobic TM3 R 116 3x50 G.H5 L 380 G.H5.25
Hydrophobic C-term K 341 - G.hgh4 F 317 G.hgh4.05
Van-der-waals C-term K 341 - G.hgh4 F 317 G.hgh4.05
Polar TM3 M 121 3x55 G.H5 K 367 G.H5.12
Van-der-waals TM3 M 121 3x55 G.H5 K 367 G.H5.12
Polar C-term P 339 - G.hgh4 R 318 G.hgh4.06
Hydrophobic C-term P 339 - G.hgh4 R 318 G.hgh4.06
Van-der-waals C-term P 339 - G.hgh4 R 318 G.hgh4.06
Polar TM5 Q 212 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 Q 212 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 Q 212 5x68 G.H5 D 368 G.H5.13
Polar H8 N 292 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 292 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 292 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM3 R 116 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 116 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 124 34x51 G.H5 V 366 G.H5.11
Polar C-term K 338 - G.HG K 311 G.HG.16
Hydrophobic C-term K 338 - G.HG K 311 G.HG.16
Van-der-waals C-term K 338 - G.HG K 311 G.HG.16
Hydrophobic TM3 V 120 3x54 G.H5 L 375 G.H5.20
Polar TM6 R 228 6x29 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 R 228 6x29 G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 L 124 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 124 34x51 G.S3 I 221 G.S3.01
Polar C-term L 342 - G.H4 R 329 G.H4.09
Hydrophobic C-term L 342 - G.H4 R 329 G.H4.09
Van-der-waals C-term L 342 - G.H4 R 329 G.H4.09
Hydrophobic ICL2 P 127 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 127 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 A 209 5x65 G.H5 M 379 G.H5.24
Polar C-term L 342 - G.H4 D 326 G.H4.06
Hydrophobic C-term L 342 - G.H4 D 326 G.H4.06
Van-der-waals C-term L 342 - G.H4 D 326 G.H4.06
Hydrophobic C-term L 342 - G.H4 Y 330 G.H4.10
Van-der-waals C-term L 342 - G.H4 Y 330 G.H4.10
Hydrophobic C-term K 341 - G.H4 D 326 G.H4.06
Van-der-waals C-term K 341 - G.H4 D 326 G.H4.06
Hydrophobic C-term V 344 - G.H4 R 329 G.H4.09
Van-der-waals C-term V 344 - G.H4 R 329 G.H4.09
Polar ICL2 V 128 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 128 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term L 340 - G.hgh4 R 318 G.hgh4.06
Van-der-waals C-term L 340 - G.hgh4 R 318 G.hgh4.06
Polar C-term L 340 - G.hgh4 D 320 G.hgh4.08
Hydrophobic C-term L 340 - G.hgh4 D 320 G.hgh4.08
Van-der-waals C-term L 340 - G.hgh4 D 320 G.hgh4.08
Hydrophobic TM5 A 209 5x65 G.H5 L 375 G.H5.20
Hydrophobic ICL2 L 124 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 L 124 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 Q 212 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 Q 212 5x68 G.H5 Q 372 G.H5.17
Van-der-waals C-term P 339 - G.hgh4 G 319 G.hgh4.07
Polar C-term L 340 - G.H4 P 321 G.H4.01
Hydrophobic C-term L 340 - G.H4 P 321 G.H4.01
Van-der-waals C-term L 340 - G.H4 P 321 G.H4.01
Hydrophobic TM5 Q 212 5x68 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 125 34x52 G.S3 I 221 G.S3.01
Hydrophobic TM6 K 231 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 231 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 232 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 232 6x33 G.H5 M 379 G.H5.24
Ionic TM3 D 122 3x56 G.H5 K 367 G.H5.12
Polar C-term N 320 - G.H3 K 284 G.H3.16
Hydrophobic C-term N 320 - G.H3 K 284 G.H3.16
Van-der-waals C-term N 320 - G.H3 K 284 G.H3.16
Hydrophobic TM5 I 216 5x72 G.H5 Q 372 G.H5.17
Hydrophobic C-term L 342 - G.H4 Q 333 G.H4.13
Van-der-waals C-term L 342 - G.H4 Q 333 G.H4.13
Hydrophobic ICL3 I 219 - G.h4s6 P 345 G.h4s6.20
Polar TM6 T 235 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 235 6x36 G.H5 M 379 G.H5.24
Hydrophobic C-term L 342 - G.hgh4 F 317 G.hgh4.05
Van-der-waals C-term L 342 - G.hgh4 F 317 G.hgh4.05
Polar TM3 A 119 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 119 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 119 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM5 V 208 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 V 208 5x64 G.H5 L 371 G.H5.16
Hydrophobic H8 R 293 8x48 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 L 124 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 124 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM2 L 52 2x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM2 L 52 2x38 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 Q 212 5x68 G.H5 L 371 G.H5.16
Polar C-term L 340 - G.hgh4 F 317 G.hgh4.05
Hydrophobic C-term L 340 - G.hgh4 F 317 G.hgh4.05
Van-der-waals C-term L 340 - G.hgh4 F 317 G.hgh4.05
Hydrophobic ICL2 P 123 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 123 34x50 G.H5 K 367 G.H5.12
Polar C-term E 337 - G.hgh4 R 318 G.hgh4.06
Van-der-waals C-term E 337 - G.hgh4 R 318 G.hgh4.06
Hydrophobic ICL2 L 124 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 124 34x51 G.H5 F 363 G.H5.08
Polar C-term L 340 - G.hgh4 G 319 G.hgh4.07
Hydrophobic C-term L 340 - G.hgh4 G 319 G.hgh4.07
Van-der-waals C-term L 340 - G.hgh4 G 319 G.hgh4.07
Hydrophobic TM3 A 119 3x53 G.H5 I 378 G.H5.23
Ionic TM5 R 215 5x71 G.H5 D 368 G.H5.13
Polar TM5 R 215 5x71 G.H5 D 368 G.H5.13
Van-der-waals TM5 R 215 5x71 G.H5 D 368 G.H5.13