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H2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | N | 292 | 8x47 | G.H5 | G | 350 | G.H5.22 |
Van-der-waals | H8 | N | 292 | 8x47 | G.H5 | G | 350 | G.H5.22 |
Hydrophobic | C-term | L | 340 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Van-der-waals | C-term | L | 340 | - | G.s4h3 | D | 238 | G.s4h3.11 |
Hydrophobic | C-term | V | 350 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | C-term | V | 350 | - | H.hbhc | T | 117 | H.hbhc.05 |
Van-der-waals | ICL2 | P | 123 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | V | 128 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | C-term | L | 342 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | L | 342 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | V | 344 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | V | 344 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | V | 344 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM5 | Q | 212 | 5x68 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | Q | 212 | 5x68 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM5 | Q | 212 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | Q | 212 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | Q | 212 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | T | 351 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Polar | TM3 | R | 116 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 116 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 116 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | TM5 | A | 213 | 5x69 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM6 | T | 235 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | T | 235 | 6x36 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | N | 292 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | I | 216 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | I | 216 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | A | 232 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 232 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 232 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM5 | R | 215 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 215 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 215 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 215 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Polar | TM3 | A | 119 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 119 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 119 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | R | 228 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 228 | 6x29 | G.h4s6 | P | 315 | G.h4s6.09 |
Hydrophobic | C-term | L | 340 | - | G.s4h3 | L | 235 | G.s4h3.08 |
Hydrophobic | TM5 | Q | 212 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | Q | 212 | 5x68 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | S | 220 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | S | 220 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 220 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | L | 236 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 236 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | C-term | E | 349 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Polar | C-term | E | 349 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Hydrophobic | C-term | E | 349 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Van-der-waals | C-term | E | 349 | - | G.hfs2 | R | 179 | G.hfs2.02 |
Polar | C-term | V | 344 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | V | 344 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | V | 344 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | TM5 | V | 208 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | I | 205 | 5x61 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | P | 123 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | P | 123 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | K | 231 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 231 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 231 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | T | 235 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | L | 124 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 124 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | TM5 | A | 209 | 5x65 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM5 | A | 209 | 5x65 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | L | 124 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM4 | P | 132 | 4x39 | G.HN | I | 28 | G.HN.52 |
Hydrophobic | TM3 | V | 120 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 120 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 124 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Aromatic | TM6 | R | 228 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 228 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 228 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | ICL2 | P | 127 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 124 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 124 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | A | 352 | - | G.hfs2 | V | 180 | G.hfs2.03 |
Polar | C-term | W | 345 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM5 | A | 209 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | T | 348 | - | H.hbhc | M | 114 | H.hbhc.02 |
Van-der-waals | C-term | T | 348 | - | H.hbhc | M | 114 | H.hbhc.02 |
Polar | H8 | R | 293 | 8x48 | G.h4s6 | N | 316 | G.h4s6.10 |
Van-der-waals | H8 | R | 293 | 8x48 | G.h4s6 | N | 316 | G.h4s6.10 |
Hydrophobic | ICL3 | I | 219 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | I | 219 | - | G.S6 | I | 319 | G.S6.01 |
Ionic | TM6 | R | 228 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 228 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 228 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 228 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | L | 340 | - | G.s4h3 | T | 241 | G.s4h3.14 |
Hydrophobic | C-term | Q | 343 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | G | 347 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Polar | TM5 | Q | 212 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | TM5 | Q | 212 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Van-der-waals | TM5 | Q | 212 | 5x68 | G.H5 | A | 345 | G.H5.17 |
Hydrophobic | TM5 | Q | 212 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | Q | 212 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | I | 219 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM5 | I | 205 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 205 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | E | 349 | - | G.hfs2 | K | 181 | G.hfs2.04 |
Hydrophobic | ICL2 | P | 123 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 123 | 34x50 | G.H5 | I | 344 | G.H5.16 |