Gt2 -
H3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | V | 136 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | V | 140 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Polar | TM2 | N | 69 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 69 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL3 | F | 344 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | TM6 | V | 356 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | V | 356 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 356 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | I | 225 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | R | 143 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 143 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 143 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | G | 147 | 34x58 | G.HN | D | 28 | G.HN.52 |
Van-der-waals | ICL2 | G | 147 | 34x58 | G.HN | D | 28 | G.HN.52 |
Hydrophobic | C-term | W | 444 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | ICL2 | Y | 142 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | S | 359 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | S | 359 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Aromatic | C-term | W | 444 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | C-term | W | 444 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | W | 444 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL2 | A | 139 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | S | 141 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | S | 141 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | V | 140 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | V | 140 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | V | 140 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL1 | S | 63 | 12x48 | G.HN | E | 20 | G.HN.44 |
Hydrophobic | TM5 | R | 228 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 228 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | V | 140 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | ICL3 | S | 341 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL3 | S | 341 | - | G.H4 | D | 309 | G.H4.17 |
Van-der-waals | ICL3 | S | 341 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL2 | A | 139 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Polar | ICL2 | A | 144 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | A | 144 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | A | 144 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM6 | L | 360 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | A | 139 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | A | 139 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | V | 140 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | V | 140 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | ICL3 | S | 341 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | R | 143 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | R | 143 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | F | 348 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | F | 348 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Ionic | H8 | H | 416 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | H | 416 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | H | 416 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | H | 416 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | H | 417 | 8x48 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | H | 417 | 8x48 | G.H5 | D | 350 | G.H5.22 |
Polar | TM5 | G | 235 | 5x75 | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | TM5 | G | 235 | 5x75 | G.H4 | K | 304 | G.H4.12 |
Polar | H8 | S | 418 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | S | 418 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | S | 418 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | H | 416 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | L | 440 | - | G.H3 | F | 258 | G.H3.17 |
Van-der-waals | C-term | L | 440 | - | G.H3 | F | 258 | G.H3.17 |
Polar | ICL3 | A | 239 | - | G.H4 | N | 301 | G.H4.08 |
Hydrophobic | ICL3 | A | 239 | - | G.H4 | N | 301 | G.H4.08 |
Van-der-waals | ICL3 | A | 239 | - | G.H4 | N | 301 | G.H4.08 |
Hydrophobic | ICL2 | A | 144 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | R | 228 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | R | 228 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Polar | C-term | S | 439 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | S | 439 | - | G.H3 | K | 257 | G.H3.16 |
Polar | TM3 | S | 135 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | S | 135 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 135 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | I | 363 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | K | 355 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 355 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 355 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Polar | H8 | H | 416 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | H8 | H | 416 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | H8 | H | 416 | 8x47 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | V | 136 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | V | 136 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL1 | R | 66 | 12x51 | G.HN | E | 20 | G.HN.44 |
Polar | ICL1 | R | 66 | 12x51 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 66 | 12x51 | G.HN | E | 20 | G.HN.44 |
Ionic | TM6 | R | 352 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 352 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 352 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM3 | R | 132 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 132 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Ionic | ICL2 | R | 143 | 34x54 | G.H5 | E | 346 | G.H5.18 |
Polar | ICL2 | R | 143 | 34x54 | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | ICL2 | R | 143 | 34x54 | G.H5 | E | 346 | G.H5.18 |
Ionic | TM5 | R | 232 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | R | 232 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | R | 232 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | R | 232 | 5x72 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | C-term | W | 444 | - | G.H3 | H | 256 | G.H3.15 |
Aromatic | C-term | W | 444 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | W | 444 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | W | 444 | - | G.H3 | H | 256 | G.H3.15 |
Polar | TM5 | R | 232 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM5 | R | 232 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | R | 232 | 5x72 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | R | 352 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 352 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Ionic | TM5 | R | 228 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 228 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 228 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | A | 239 | - | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | ICL3 | A | 239 | - | G.H4 | K | 304 | G.H4.12 |
Polar | ICL3 | E | 238 | - | G.H4 | N | 301 | G.H4.08 |
Polar | TM7 | C | 415 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM7 | C | 415 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | C | 415 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Aromatic | H8 | H | 417 | 8x48 | G.H5 | K | 349 | G.H5.21 |
Polar | C-term | C | 443 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | C | 443 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | C | 443 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | W | 444 | - | G.H3 | I | 253 | G.H3.12 |
Van-der-waals | C-term | W | 444 | - | G.H3 | I | 253 | G.H3.12 |
Ionic | TM5 | R | 232 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 232 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 232 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 232 | 5x72 | G.H5 | D | 341 | G.H5.13 |