Gt2 - H4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 T 124 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 T 124 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 T 124 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 A 119 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM6 R 297 6x29 G.H5 F 354 G.H5.26
Hydrophobic TM6 S 304 6x36 G.H5 L 353 G.H5.25
Ionic ICL2 H 126 - G.HN D 28 G.HN.52
Polar ICL2 H 126 - G.HN D 28 G.HN.52
Hydrophobic ICL2 H 126 - G.HN D 28 G.HN.52
Van-der-waals ICL2 H 126 - G.HN D 28 G.HN.52
Ionic TM5 R 204 5x68 G.H5 D 341 G.H5.13
Polar TM5 R 204 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 204 5x68 G.H5 D 341 G.H5.13
Polar ICL3 H 213 - G.H4 N 301 G.H4.08
Hydrophobic ICL3 H 213 - G.H4 N 301 G.H4.08
Van-der-waals ICL3 H 213 - G.H4 N 301 G.H4.08
Hydrophobic ICL3 A 286 - G.H4 D 309 G.H4.17
Van-der-waals ICL3 A 286 - G.H4 D 309 G.H4.17
Hydrophobic TM3 V 116 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 V 116 3x54 G.H5 I 344 G.H5.16
Ionic ICL3 R 290 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 R 290 - G.h4s6 E 318 G.h4s6.12
Ionic H8 R 364 8x49 G.H5 D 350 G.H5.22
Polar H8 R 364 8x49 G.H5 D 350 G.H5.22
Hydrophobic H8 R 364 8x49 G.H5 D 350 G.H5.22
Van-der-waals H8 R 364 8x49 G.H5 D 350 G.H5.22
Hydrophobic TM6 L 308 6x40 G.H5 L 353 G.H5.25
Hydrophobic TM6 R 297 6x29 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 297 6x29 G.H5 K 345 G.H5.17
Polar TM6 R 297 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 297 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 L 301 6x33 G.H5 L 348 G.H5.20
Polar ICL3 R 290 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 R 290 - G.S6 I 319 G.S6.01
Van-der-waals ICL3 R 290 - G.S6 I 319 G.S6.01
Hydrophobic ICL3 G 215 - G.H4 N 301 G.H4.08
Hydrophobic ICL2 V 120 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 124 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 T 124 34x55 G.s2s3 D 193 G.s2s3.02
Polar TM6 R 297 6x29 G.h4s6 V 316 G.h4s6.10
Van-der-waals TM6 R 297 6x29 G.h4s6 V 316 G.h4s6.10
Polar ICL3 Q 289 - G.h4s6 K 314 G.h4s6.08
Van-der-waals ICL2 V 120 34x51 G.s2s3 K 192 G.s2s3.01
Polar ICL2 A 119 34x50 G.H5 N 347 G.H5.19
Polar H8 H 362 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 H 362 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 H 362 8x47 G.H5 G 352 G.H5.24
Hydrophobic TM5 R 204 5x68 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 204 5x68 G.H5 I 344 G.H5.16
Polar TM3 R 112 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 112 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 112 3x50 G.H5 C 351 G.H5.23
Polar ICL2 H 126 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 H 126 - G.HN Q 24 G.HN.48
Van-der-waals ICL2 H 126 - G.HN Q 24 G.HN.48
Polar H8 H 362 8x47 G.H5 D 350 G.H5.22
Hydrophobic H8 H 362 8x47 G.H5 D 350 G.H5.22
Van-der-waals H8 H 362 8x47 G.H5 D 350 G.H5.22
Ionic ICL1 K 44 12x48 G.HN E 20 G.HN.44
Polar ICL1 K 44 12x48 G.HN E 20 G.HN.44
Van-der-waals ICL1 K 44 12x48 G.HN E 20 G.HN.44
Hydrophobic ICL2 V 120 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 V 120 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM3 R 112 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 R 123 34x54 G.H5 I 343 G.H5.15
Hydrophobic TM5 S 212 5x76 G.H4 K 304 G.H4.12
Van-der-waals TM5 S 212 5x76 G.H4 K 304 G.H4.12
Hydrophobic ICL3 A 218 - G.H4 S 305 G.H4.13
Hydrophobic TM7 C 361 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 C 361 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 V 293 6x25 G.h4s6 D 315 G.h4s6.09
Polar H8 H 362 8x47 G.H5 C 351 G.H5.23
Hydrophobic H8 H 362 8x47 G.H5 C 351 G.H5.23
Van-der-waals H8 H 362 8x47 G.H5 C 351 G.H5.23
Hydrophobic TM5 L 201 5x65 G.H5 I 344 G.H5.16
Van-der-waals TM5 L 201 5x65 G.H5 I 344 G.H5.16
Polar TM3 S 115 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 115 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 115 3x53 G.H5 C 351 G.H5.23
Ionic TM6 R 297 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 297 6x29 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 297 6x29 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 L 301 6x33 G.H5 L 353 G.H5.25
Hydrophobic ICL2 Y 122 34x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 V 116 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 116 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM5 R 204 5x68 G.H5 T 340 G.H5.12
Van-der-waals TM5 R 204 5x68 G.H5 T 340 G.H5.12
Polar ICL2 R 123 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 123 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 123 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 V 120 34x51 G.H5 F 336 G.H5.08
Ionic ICL2 R 123 34x54 G.H5 E 346 G.H5.18
Polar ICL2 R 123 34x54 G.H5 E 346 G.H5.18
Van-der-waals ICL2 R 123 34x54 G.H5 E 346 G.H5.18
Hydrophobic ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 A 119 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 124 34x55 G.S3 L 194 G.S3.01
Van-der-waals ICL2 T 124 34x55 G.S3 L 194 G.S3.01
Aromatic ICL3 R 290 - G.S6 Y 320 G.S6.02
Hydrophobic TM6 L 305 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 201 5x65 G.H5 L 348 G.H5.20
Polar TM3 S 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 115 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 115 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 Q 211 5x75 G.H5 F 334 G.H5.06
Hydrophobic ICL2 V 120 34x51 G.H5 T 340 G.H5.12
Polar TM5 Q 211 5x75 G.S6 H 322 G.S6.04
Hydrophobic TM5 Q 211 5x75 G.S6 H 322 G.S6.04
Van-der-waals TM5 Q 211 5x75 G.S6 H 322 G.S6.04
Polar TM5 Q 211 5x75 G.H4 K 304 G.H4.12