G12 -
kisspeptin receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM7 | L | 322 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | L | 322 | 7x52 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | E | 362 | - | G.H3 | N | 283 | G.H3.15 |
Hydrophobic | ICL2 | L | 151 | 34x54 | G.S1 | V | 58 | G.S1.02 |
Ionic | TM5 | D | 242 | 5x76 | G.S6 | H | 349 | G.S6.04 |
Polar | TM5 | D | 242 | 5x76 | G.S6 | H | 349 | G.S6.04 |
Hydrophobic | TM5 | D | 242 | 5x76 | G.S6 | H | 349 | G.S6.04 |
Van-der-waals | TM5 | D | 242 | 5x76 | G.S6 | H | 349 | G.S6.04 |
Polar | TM2 | T | 77 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | T | 77 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | T | 77 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Polar | C-term | N | 395 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Van-der-waals | C-term | N | 395 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Polar | TM6 | K | 260 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | K | 260 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 260 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Polar | TM5 | S | 243 | 5x77 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM6 | V | 261 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 261 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | L | 363 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | C-term | L | 398 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | ICL2 | H | 152 | 34x55 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | C-term | P | 359 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | P | 359 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | C-term | L | 366 | - | G.H3 | I | 280 | G.H3.12 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM5 | Q | 246 | 5x80 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | Q | 246 | 5x80 | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | TM5 | Q | 246 | 5x80 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM6 | R | 253 | 6x25 | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | TM6 | R | 253 | 6x25 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM4 | P | 156 | 4x39 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | C-term | L | 366 | - | G.H3 | I | 276 | G.H3.08 |
Polar | TM2 | T | 75 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM5 | A | 239 | 5x73 | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | C-term | P | 359 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | ICL2 | L | 151 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 151 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | P | 240 | 5x74 | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | TM5 | P | 240 | 5x74 | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | TM3 | T | 144 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Polar | C-term | G | 387 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | G | 387 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM5 | L | 231 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 231 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM4 | T | 155 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM4 | T | 155 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM5 | V | 234 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | H8 | H | 329 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | L | 250 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | L | 250 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | C-term | L | 363 | - | G.H3 | F | 286 | G.H3.18 |
Polar | C-term | H | 369 | - | G.H2 | R | 232 | G.H2.01 |
Aromatic | C-term | H | 369 | - | G.H2 | R | 232 | G.H2.01 |
Hydrophobic | C-term | H | 369 | - | G.H2 | R | 232 | G.H2.01 |
Van-der-waals | C-term | H | 369 | - | G.H2 | R | 232 | G.H2.01 |
Hydrophobic | H8 | G | 327 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | G | 327 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | P | 359 | - | G.H3 | N | 283 | G.H3.15 |
Hydrophobic | C-term | P | 359 | - | G.H3 | N | 283 | G.H3.15 |
Van-der-waals | C-term | P | 359 | - | G.H3 | N | 283 | G.H3.15 |
Polar | TM3 | V | 143 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | V | 143 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | V | 143 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | L | 363 | - | G.H3 | N | 283 | G.H3.15 |
Van-der-waals | C-term | L | 363 | - | G.H3 | N | 283 | G.H3.15 |
Ionic | ICL2 | R | 154 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Polar | ICL2 | R | 154 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | ICL2 | R | 154 | 34x57 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | C-term | H | 360 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | H | 360 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | TM7 | Y | 323 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | Y | 323 | 7x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | V | 261 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Polar | C-term | D | 394 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | ICL2 | L | 151 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | L | 151 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | L | 364 | - | G.H2 | F | 239 | G.H2.08 |
Polar | C-term | A | 396 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Van-der-waals | C-term | A | 396 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | L | 388 | - | H.HA | L | 115 | H.HA.29 |
Hydrophobic | C-term | L | 363 | - | G.H3 | L | 285 | G.H3.17 |
Van-der-waals | C-term | L | 363 | - | G.H3 | L | 285 | G.H3.17 |
Hydrophobic | TM5 | L | 231 | 5x65 | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | L | 366 | - | G.H2 | R | 235 | G.H2.04 |
Hydrophobic | C-term | L | 366 | - | G.H2 | R | 235 | G.H2.04 |
Van-der-waals | C-term | L | 366 | - | G.H2 | R | 235 | G.H2.04 |
Hydrophobic | C-term | L | 363 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Van-der-waals | C-term | L | 363 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Hydrophobic | C-term | E | 362 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | C-term | V | 390 | - | G.s4h3 | M | 262 | G.s4h3.09 |
Ionic | ICL1 | K | 71 | 12x48 | G.HN | D | 44 | G.HN.44 |
Polar | ICL1 | K | 71 | 12x48 | G.HN | D | 44 | G.HN.44 |
Hydrophobic | TM3 | V | 143 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 143 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | H8 | S | 328 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | S | 328 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM2 | I | 81 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | C-term | L | 388 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | L | 388 | - | H.HA | K | 114 | H.HA.28 |
Polar | C-term | E | 393 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | C-term | E | 393 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Van-der-waals | C-term | E | 393 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | TM6 | K | 260 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 260 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | H | 152 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | H | 152 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | H | 152 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM5 | D | 242 | 5x76 | G.S6 | F | 350 | G.S6.05 |
Hydrophobic | TM5 | D | 242 | 5x76 | G.S6 | F | 350 | G.S6.05 |
Van-der-waals | TM5 | D | 242 | 5x76 | G.S6 | F | 350 | G.S6.05 |
Polar | TM3 | R | 140 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 140 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 140 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | L | 366 | - | G.H3 | T | 279 | G.H3.11 |
Van-der-waals | C-term | L | 366 | - | G.H3 | T | 279 | G.H3.11 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 147 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM7 | A | 324 | 7x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | V | 257 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | V | 257 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | L | 250 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | ICL3 | L | 250 | - | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | C-term | L | 391 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | L | 391 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | TM5 | Q | 246 | 5x80 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | ICL2 | L | 148 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 148 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | H8 | H | 329 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | H | 329 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | H | 329 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Polar | C-term | L | 388 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | L | 388 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | L | 388 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | G | 367 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | G | 367 | - | G.H2 | Q | 236 | G.H2.05 |
Hydrophobic | C-term | L | 388 | - | H.HA | A | 111 | H.HA.25 |
Van-der-waals | C-term | L | 388 | - | H.HA | A | 111 | H.HA.25 |
Polar | TM5 | Q | 246 | 5x80 | G.S6 | L | 346 | G.S6.01 |
Van-der-waals | TM5 | Q | 246 | 5x80 | G.S6 | L | 346 | G.S6.01 |
Hydrophobic | TM5 | D | 242 | 5x76 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM6 | V | 257 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | V | 390 | - | H.hdhe | Q | 174 | H.hdhe.02 |
Polar | C-term | C | 389 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | C | 389 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | C | 389 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | ICL2 | P | 147 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | H | 152 | 34x55 | G.S3 | P | 222 | G.S3.02 |
Van-der-waals | ICL2 | H | 152 | 34x55 | G.S3 | P | 222 | G.S3.02 |
Hydrophobic | C-term | L | 388 | - | H.hdhe | F | 173 | H.hdhe.01 |
Hydrophobic | TM6 | L | 264 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | C-term | L | 391 | - | H.HA | R | 106 | H.HA.20 |
Hydrophobic | C-term | L | 363 | - | G.H3 | I | 280 | G.H3.12 |
Van-der-waals | C-term | L | 363 | - | G.H3 | I | 280 | G.H3.12 |
Hydrophobic | C-term | V | 390 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | V | 390 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | C | 389 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | G | 367 | - | G.H2 | R | 235 | G.H2.04 |
Polar | H8 | S | 328 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 328 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | R | 253 | 6x25 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM6 | R | 253 | 6x25 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | TM6 | R | 253 | 6x25 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM6 | R | 253 | 6x25 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM6 | R | 253 | 6x25 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | ICL2 | L | 151 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | C-term | L | 366 | - | G.H2 | W | 238 | G.H2.07 |
Hydrophobic | TM3 | T | 144 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | T | 144 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | E | 393 | - | G.hfs2 | A | 207 | G.hfs2.04 |
Hydrophobic | TM6 | L | 264 | 6x36 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | G | 367 | - | G.H2 | R | 232 | G.H2.01 |
Van-der-waals | C-term | G | 367 | - | G.H2 | R | 232 | G.H2.01 |
Hydrophobic | C-term | H | 369 | - | G.s4h3 | D | 264 | G.s4h3.11 |