G14 - kisspeptin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 L 264 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 264 6x36 G.H5 L 354 G.H5.25
Polar TM3 R 140 3x50 G.H5 F 352 G.H5.23
Hydrophobic TM3 R 140 3x50 G.H5 F 352 G.H5.23
Van-der-waals TM3 R 140 3x50 G.H5 F 352 G.H5.23
Hydrophobic ICL2 L 148 34x51 G.H5 I 344 G.H5.15
Van-der-waals ICL2 L 148 34x51 G.H5 I 344 G.H5.15
Hydrophobic ICL2 L 148 34x51 G.H5 V 340 G.H5.11
Polar C-term H 369 - G.H3 T 253 G.H3.11
Van-der-waals C-term H 369 - G.H3 T 253 G.H3.11
Hydrophobic H8 H 329 8x49 G.H5 R 350 G.H5.21
Hydrophobic ICL2 L 148 34x51 G.H5 K 341 G.H5.12
Hydrophobic C-term L 366 - G.H3 T 253 G.H3.11
Hydrophobic ICL2 P 147 34x50 G.H5 I 344 G.H5.15
Polar H8 S 328 8x48 G.H5 N 353 G.H5.24
Polar TM2 T 75 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM2 T 75 2x37 G.H5 E 351 G.H5.22
Van-der-waals TM2 T 75 2x37 G.H5 E 351 G.H5.22
Hydrophobic TM7 L 326 7x56 G.H5 N 353 G.H5.24
Hydrophobic C-term L 363 - G.H2 I 213 G.H2.08
Polar C-term L 366 - G.H2 R 209 G.H2.04
Hydrophobic C-term L 366 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 366 - G.H2 R 209 G.H2.04
Hydrophobic ICL2 L 151 34x54 G.H5 I 344 G.H5.15
Hydrophobic TM5 P 240 5x74 G.H5 A 338 G.H5.09
Hydrophobic TM6 R 253 6x25 G.h4s6 V 319 G.h4s6.20
Van-der-waals TM6 R 253 6x25 G.h4s6 V 319 G.h4s6.20
Hydrophobic TM6 V 261 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 148 34x51 G.S3 I 195 G.S3.01
Van-der-waals ICL2 L 148 34x51 G.S3 I 195 G.S3.01
Hydrophobic TM6 K 260 6x32 G.H5 L 354 G.H5.25
Van-der-waals TM6 K 260 6x32 G.H5 L 354 G.H5.25
Hydrophobic TM5 M 227 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 231 5x65 G.H5 L 345 G.H5.16
Ionic TM5 D 242 5x76 G.S6 H 323 G.S6.04
Polar TM5 D 242 5x76 G.S6 H 323 G.S6.04
Hydrophobic TM5 D 242 5x76 G.S6 H 323 G.S6.04
Van-der-waals TM5 D 242 5x76 G.S6 H 323 G.S6.04
Polar C-term G 367 - G.H2 R 206 G.H2.01
Hydrophobic C-term G 367 - G.H2 R 206 G.H2.01
Van-der-waals C-term G 367 - G.H2 R 206 G.H2.01
Hydrophobic ICL2 H 152 34x55 G.S3 I 195 G.S3.01
Hydrophobic TM3 T 144 3x54 G.H5 L 345 G.H5.16
Van-der-waals TM3 T 144 3x54 G.H5 L 345 G.H5.16
Hydrophobic C-term L 366 - G.H3 Y 257 G.H3.15
Van-der-waals C-term L 366 - G.H3 Y 257 G.H3.15
Polar H8 G 327 8x47 G.H5 N 353 G.H5.24
Hydrophobic H8 G 327 8x47 G.H5 N 353 G.H5.24
Van-der-waals H8 G 327 8x47 G.H5 N 353 G.H5.24
Polar TM6 R 253 6x25 G.h4s6 K 316 G.h4s6.11
Polar TM6 K 260 6x32 G.H5 V 355 G.H5.26
Hydrophobic TM6 K 260 6x32 G.H5 V 355 G.H5.26
Van-der-waals TM6 K 260 6x32 G.H5 V 355 G.H5.26
Hydrophobic TM3 D 139 3x49 G.H5 F 352 G.H5.23
Van-der-waals TM3 D 139 3x49 G.H5 F 352 G.H5.23
Polar TM3 V 143 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 V 143 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 V 143 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM5 L 231 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 P 240 5x74 G.H5 F 335 G.H5.06
Van-der-waals TM5 P 240 5x74 G.H5 F 335 G.H5.06
Hydrophobic ICL2 P 147 34x50 G.H5 K 341 G.H5.12
Van-der-waals ICL2 P 147 34x50 G.H5 K 341 G.H5.12
Hydrophobic C-term L 366 - G.H3 I 254 G.H3.12
Hydrophobic C-term L 366 - G.H3 L 250 G.H3.08
Van-der-waals C-term L 366 - G.H3 L 250 G.H3.08
Polar C-term L 363 - G.H3 Y 257 G.H3.15
Hydrophobic TM5 S 243 5x77 G.H4 L 306 G.H4.12
Polar TM6 V 261 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 261 6x33 G.H5 L 354 G.H5.25
Polar TM2 T 77 2x39 G.H5 E 351 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 E 351 G.H5.22
Van-der-waals TM2 T 77 2x39 G.H5 E 351 G.H5.22
Hydrophobic TM2 T 77 2x39 G.H5 F 352 G.H5.23
Van-der-waals TM2 T 77 2x39 G.H5 F 352 G.H5.23
Hydrophobic TM6 V 257 6x29 G.H5 L 349 G.H5.20
Van-der-waals TM6 V 257 6x29 G.H5 L 349 G.H5.20
Hydrophobic ICL2 L 151 34x54 G.S1 L 36 G.S1.02
Van-der-waals ICL2 L 151 34x54 G.S1 L 36 G.S1.02
Hydrophobic TM4 R 157 4x40 G.HN K 30 G.HN.52
Van-der-waals TM4 R 157 4x40 G.HN K 30 G.HN.52
Hydrophobic ICL3 L 250 - G.S6 Y 321 G.S6.02
Hydrophobic TM6 V 257 6x29 G.H5 V 355 G.H5.26
Hydrophobic ICL2 R 154 34x57 G.H5 F 352 G.H5.23
Van-der-waals ICL2 R 154 34x57 G.H5 F 352 G.H5.23
Polar TM5 Q 246 5x80 G.S6 S 322 G.S6.03
Hydrophobic TM5 Q 246 5x80 G.S6 S 322 G.S6.03
Van-der-waals TM5 Q 246 5x80 G.S6 S 322 G.S6.03
Polar TM5 D 242 5x76 G.S6 F 324 G.S6.05
Hydrophobic TM5 D 242 5x76 G.S6 F 324 G.S6.05
Van-der-waals TM5 D 242 5x76 G.S6 F 324 G.S6.05
Hydrophobic ICL2 P 147 34x50 G.H5 L 345 G.H5.16
Polar ICL2 H 152 34x55 G.hns1 R 34 G.hns1.03
Hydrophobic ICL2 H 152 34x55 G.hns1 R 34 G.hns1.03
Van-der-waals ICL2 H 152 34x55 G.hns1 R 34 G.hns1.03
Polar TM6 R 253 6x25 G.h4s6 E 317 G.h4s6.12
Hydrophobic TM6 R 253 6x25 G.h4s6 E 317 G.h4s6.12
Van-der-waals TM6 R 253 6x25 G.h4s6 E 317 G.h4s6.12
Hydrophobic TM3 T 144 3x54 G.H5 L 349 G.H5.20
Hydrophobic C-term L 363 - G.H2 R 210 G.H2.05
Van-der-waals C-term L 363 - G.H2 R 210 G.H2.05
Polar C-term H 369 - G.H3 A 249 G.H3.07
Hydrophobic C-term H 369 - G.H3 A 249 G.H3.07
Van-der-waals C-term H 369 - G.H3 A 249 G.H3.07
Hydrophobic ICL2 L 148 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 L 148 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM6 L 264 6x36 G.H5 N 353 G.H5.24
Van-der-waals TM6 L 264 6x36 G.H5 N 353 G.H5.24
Polar C-term E 362 - G.H3 Y 257 G.H3.15
Hydrophobic C-term E 362 - G.H3 Y 257 G.H3.15
Van-der-waals C-term E 362 - G.H3 Y 257 G.H3.15
Polar TM5 Q 246 5x80 G.S6 I 320 G.S6.01
Van-der-waals TM5 Q 246 5x80 G.S6 I 320 G.S6.01
Hydrophobic TM5 A 239 5x73 G.H5 A 338 G.H5.09
Polar ICL2 H 152 34x55 G.s2s3 N 194 G.s2s3.02
Hydrophobic ICL3 L 250 - G.h4s6 V 319 G.h4s6.20
Van-der-waals ICL3 L 250 - G.h4s6 V 319 G.h4s6.20
Hydrophobic TM3 V 143 3x53 G.H5 F 352 G.H5.23
Hydrophobic ICL2 L 148 34x51 G.S1 L 36 G.S1.02
Polar TM7 A 324 7x54 G.H5 N 353 G.H5.24
Hydrophobic TM4 P 156 4x39 G.hns1 R 33 G.hns1.02
Van-der-waals TM4 P 156 4x39 G.hns1 R 33 G.hns1.02
Polar TM7 Y 323 7x53 G.H5 N 353 G.H5.24
Van-der-waals TM7 Y 323 7x53 G.H5 N 353 G.H5.24