Gs -
LPA1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 14.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | L | 256 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | V | 232 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL3 | H | 242 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | ICL3 | H | 242 | - | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | ICL3 | H | 242 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | TM5 | R | 235 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | R | 235 | 5x68 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | M | 153 | 34x50 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL3 | H | 242 | - | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | ICL3 | H | 242 | - | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | TM7 | R | 314 | 7x56 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | L | 155 | 34x52 | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | E | 339 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | E | 339 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | E | 339 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM3 | V | 150 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 150 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Polar | C-term | N | 349 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | C-term | N | 349 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM7 | R | 314 | 7x56 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM2 | I | 84 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | I | 84 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | Q | 154 | 34x51 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Q | 154 | 34x51 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Q | 154 | 34x51 | G.H5 | H | 387 | G.H5.19 |
Polar | TM6 | R | 248 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | TM6 | R | 248 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Van-der-waals | TM6 | R | 248 | 6x25 | G.h4s6 | G | 353 | G.h4s6.09 |
Polar | TM3 | T | 149 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | T | 149 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | T | 149 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | D | 342 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | TM5 | Y | 225 | 5x58 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | M | 239 | 5x72 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | ICL2 | Q | 154 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | TM6 | R | 248 | 6x25 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | C-term | G | 340 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | G | 340 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | G | 340 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM6 | T | 252 | 6x29 | G.H5 | R | 385 | G.H5.17 |
Polar | TM3 | E | 145 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | E | 145 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM5 | M | 239 | 5x72 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.H5 | M | 386 | G.H5.18 |
Van-der-waals | ICL2 | L | 155 | 34x52 | G.H5 | M | 386 | G.H5.18 |
Hydrophobic | TM6 | T | 252 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | T | 252 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | Q | 154 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Polar | TM3 | R | 146 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 146 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | H8 | D | 315 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | D | 315 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | D | 315 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.h2s4 | T | 242 | G.h2s4.05 |
Polar | TM6 | R | 248 | 6x25 | G.h4s6 | S | 349 | G.h4s6.02 |
Hydrophobic | ICL2 | H | 156 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | H | 156 | 34x53 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM6 | L | 256 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | L | 256 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | L | 256 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | C-term | S | 344 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Polar | TM6 | T | 259 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | T | 259 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | T | 259 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Polar | TM7 | R | 314 | 7x56 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM7 | R | 314 | 7x56 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM7 | R | 314 | 7x56 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | R | 158 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | ICL2 | R | 158 | 34x55 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | ICL3 | S | 244 | - | G.H4 | L | 346 | G.H4.16 |
Van-der-waals | ICL3 | S | 244 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | TM3 | V | 150 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | ICL2 | T | 157 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | T | 157 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM5 | R | 235 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | R | 235 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | R | 235 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Polar | TM3 | R | 152 | 3x56 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | R | 152 | 3x56 | G.H5 | H | 387 | G.H5.19 |
Ionic | C-term | D | 342 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM5 | Y | 231 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | Y | 231 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | Y | 231 | 5x64 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM6 | T | 259 | 6x36 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | Y | 85 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM2 | Y | 85 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | L | 348 | - | G.HN | K | 34 | G.HN.51 |
Hydrophobic | C-term | L | 348 | - | G.HN | K | 34 | G.HN.51 |
Van-der-waals | C-term | L | 348 | - | G.HN | K | 34 | G.HN.51 |
Polar | TM5 | Y | 231 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | TM5 | Y | 231 | 5x64 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL3 | S | 244 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | M | 153 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM6 | N | 249 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | N | 249 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | S | 243 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | ICL2 | T | 157 | 34x54 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM5 | M | 239 | 5x72 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM7 | Y | 311 | 7x53 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | S | 255 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | S | 255 | 6x32 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | V | 150 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | C-term | L | 348 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | L | 348 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | C-term | L | 348 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM3 | T | 149 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | T | 149 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | T | 149 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Polar | ICL2 | M | 153 | 34x50 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | M | 153 | 34x50 | G.S1 | H | 41 | G.S1.02 |
Polar | TM6 | R | 248 | 6x25 | G.h4s6 | H | 357 | G.h4s6.13 |
Aromatic | TM6 | R | 248 | 6x25 | G.h4s6 | H | 357 | G.h4s6.13 |