Gz -
LPA1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 88.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | T | 149 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | T | 149 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | T | 149 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | TM3 | R | 146 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Polar | C-term | H | 361 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | H | 361 | - | G.H2 | R | 206 | G.H2.01 |
Polar | TM6 | R | 248 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM5 | V | 232 | 5x65 | G.H5 | I | 345 | G.H5.16 |
Polar | ICL3 | H | 242 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | H | 242 | - | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | TM5 | V | 232 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Ionic | C-term | H | 361 | - | G.H2 | E | 208 | G.H2.03 |
Polar | C-term | H | 361 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | C-term | H | 361 | - | G.H2 | E | 208 | G.H2.03 |
Van-der-waals | C-term | H | 361 | - | G.H2 | E | 208 | G.H2.03 |
Hydrophobic | TM6 | L | 256 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | R | 235 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM3 | T | 149 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | T | 149 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM5 | I | 228 | 5x61 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | L | 155 | 34x52 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | C-term | V | 364 | - | G.S3 | V | 202 | G.S3.08 |
Hydrophobic | C-term | V | 364 | - | G.S1 | L | 39 | G.S1.07 |
Van-der-waals | C-term | V | 364 | - | G.S1 | L | 39 | G.S1.07 |
Ionic | TM5 | R | 238 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Polar | TM5 | R | 238 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | R | 238 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | R | 238 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Polar | TM7 | R | 314 | 7x56 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM7 | R | 314 | 7x56 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | Q | 154 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL3 | S | 244 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | S | 244 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM3 | V | 150 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | V | 364 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | V | 364 | - | G.H2 | R | 209 | G.H2.04 |
Polar | ICL3 | S | 243 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | S | 243 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 243 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM5 | Y | 225 | 5x58 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | TM6 | R | 248 | 6x25 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | TM6 | R | 248 | 6x25 | G.h4s6 | T | 317 | G.h4s6.10 |
Van-der-waals | TM6 | R | 248 | 6x25 | G.h4s6 | T | 317 | G.h4s6.10 |
Polar | ICL2 | H | 156 | 34x53 | G.hns1 | R | 31 | G.hns1.02 |
Aromatic | ICL2 | H | 156 | 34x53 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | H | 156 | 34x53 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | H | 156 | 34x53 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL3 | S | 243 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | S | 243 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM2 | F | 82 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | F | 82 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM5 | R | 235 | 5x68 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM7 | R | 314 | 7x56 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM7 | R | 314 | 7x56 | G.H5 | C | 355 | G.H5.26 |
Polar | C-term | V | 364 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Van-der-waals | C-term | V | 364 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM5 | M | 239 | 5x72 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | M | 153 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Polar | TM6 | T | 252 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | T | 252 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | T | 252 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 146 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.H5 | A | 339 | G.H5.10 |
Hydrophobic | TM6 | S | 255 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | S | 255 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM3 | T | 149 | 3x53 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | I | 84 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Polar | TM6 | R | 248 | 6x25 | G.h4s6 | K | 318 | G.h4s6.11 |
Van-der-waals | TM6 | R | 248 | 6x25 | G.h4s6 | K | 318 | G.h4s6.11 |
Hydrophobic | TM5 | Y | 231 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | Y | 231 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | A | 345 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | H | 361 | - | G.H2 | S | 207 | G.H2.02 |
Polar | C-term | S | 362 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | S | 362 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | S | 362 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | V | 364 | - | G.H1 | K | 46 | G.H1.01 |
Van-der-waals | C-term | V | 364 | - | G.H1 | K | 46 | G.H1.01 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.S1 | I | 34 | G.S1.02 |
Ionic | TM6 | R | 248 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 248 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | R | 248 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | H | 242 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | H | 242 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | C-term | V | 364 | - | G.s1h1 | G | 40 | G.s1h1.01 |
Polar | TM6 | N | 249 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | N | 249 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | S | 243 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | C-term | L | 348 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | C-term | L | 348 | - | G.H3 | N | 258 | G.H3.16 |
Hydrophobic | C-term | L | 348 | - | G.h3s5 | I | 261 | G.h3s5.01 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.S3 | L | 195 | G.S3.01 |
Polar | ICL3 | S | 244 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | S | 244 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | S | 244 | - | G.S6 | I | 320 | G.S6.01 |
Ionic | C-term | D | 360 | - | G.H2 | R | 209 | G.H2.04 |
Polar | C-term | D | 360 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | D | 360 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | D | 360 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM5 | R | 235 | 5x68 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | ICL2 | Q | 154 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | V | 364 | - | G.H3 | L | 250 | G.H3.08 |
Polar | C-term | A | 345 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | A | 345 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | C-term | D | 360 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM2 | I | 84 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | V | 150 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | V | 150 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | L | 155 | 34x52 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 155 | 34x52 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | S | 346 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | S | 346 | - | G.H3 | W | 259 | G.H3.17 |
Aromatic | ICL3 | H | 242 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | ICL3 | H | 242 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | H | 242 | - | G.H5 | F | 335 | G.H5.06 |
Polar | TM6 | T | 252 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | T | 252 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | T | 252 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Polar | TM6 | T | 259 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 259 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 259 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 256 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | A | 345 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | C-term | A | 345 | - | G.H3 | N | 258 | G.H3.16 |
Hydrophobic | C-term | V | 363 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Polar | TM3 | R | 146 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 146 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 146 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Ionic | TM5 | R | 235 | 5x68 | G.H5 | D | 338 | G.H5.09 |
Polar | TM5 | R | 235 | 5x68 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | R | 235 | 5x68 | G.H5 | D | 338 | G.H5.09 |
Polar | TM6 | L | 256 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 256 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | V | 363 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM6 | T | 252 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | V | 364 | - | G.s3h2 | Q | 205 | G.s3h2.03 |
Hydrophobic | ICL2 | M | 153 | 34x50 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | M | 239 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | C-term | S | 344 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | S | 344 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | TM5 | M | 239 | 5x72 | G.H5 | D | 342 | G.H5.13 |