G15 -
LPA2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Van-der-waals | TM6 | Y | 229 | 6x26 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | ICL1 | R | 58 | 12x48 | G.HN | W | 7 | G.HN.07 |
Hydrophobic | TM3 | S | 129 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | V | 212 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | TM6 | R | 228 | 6x25 | G.h4s6 | Y | 320 | G.h4s6.02 |
Polar | TM6 | Y | 229 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | Y | 229 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | Y | 229 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | ICL2 | R | 138 | 34x55 | G.HN | L | 33 | G.HN.48 |
Van-der-waals | ICL2 | R | 138 | 34x55 | G.HN | L | 33 | G.HN.48 |
Hydrophobic | ICL2 | L | 135 | 34x52 | G.h2s4 | I | 227 | G.h2s4.05 |
Polar | ICL3 | S | 224 | - | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | ICL3 | S | 224 | - | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | ICL3 | S | 224 | - | G.H4 | T | 317 | G.H4.16 |
Polar | TM6 | L | 236 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | L | 236 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | L | 236 | 6x33 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | T | 239 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | T | 239 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | T | 239 | 6x36 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | R | 138 | 34x55 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | ICL2 | R | 138 | 34x55 | G.HN | K | 36 | G.HN.51 |
Van-der-waals | ICL2 | R | 138 | 34x55 | G.HN | K | 36 | G.HN.51 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | V | 130 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Polar | TM5 | R | 218 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM5 | R | 218 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | R | 218 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL2 | H | 136 | 34x53 | G.hns1 | G | 41 | G.hns1.03 |
Aromatic | ICL3 | H | 222 | - | G.S6 | H | 342 | G.S6.04 |
Hydrophobic | ICL3 | H | 222 | - | G.S6 | H | 342 | G.S6.04 |
Van-der-waals | ICL3 | H | 222 | - | G.S6 | H | 342 | G.S6.04 |
Hydrophobic | ICL2 | H | 136 | 34x53 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | H | 136 | 34x53 | G.h2s4 | I | 227 | G.h2s4.05 |
Polar | ICL2 | H | 136 | 34x53 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | H | 136 | 34x53 | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | H | 136 | 34x53 | G.S1 | E | 42 | G.S1.01 |
Ionic | TM6 | R | 228 | 6x25 | G.h4s6 | D | 325 | G.h4s6.07 |
Polar | TM6 | R | 228 | 6x25 | G.h4s6 | D | 325 | G.h4s6.07 |
Van-der-waals | TM6 | R | 228 | 6x25 | G.h4s6 | D | 325 | G.h4s6.07 |
Hydrophobic | ICL2 | L | 135 | 34x52 | G.H5 | V | 359 | G.H5.11 |
Van-der-waals | ICL2 | L | 135 | 34x52 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | V | 130 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM5 | Y | 205 | 5x58 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL3 | H | 222 | - | G.S6 | S | 341 | G.S6.03 |
Van-der-waals | ICL3 | H | 222 | - | G.S6 | S | 341 | G.S6.03 |
Hydrophobic | TM5 | M | 219 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | M | 219 | 5x72 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 215 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | R | 215 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | TM5 | R | 215 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM6 | R | 228 | 6x25 | G.h4s6 | V | 324 | G.h4s6.06 |
Van-der-waals | TM6 | R | 228 | 6x25 | G.h4s6 | V | 324 | G.h4s6.06 |
Hydrophobic | ICL2 | L | 135 | 34x52 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 135 | 34x52 | G.S1 | L | 43 | G.S1.02 |
Polar | TM6 | R | 228 | 6x25 | G.h4s6 | R | 337 | G.h4s6.19 |
Van-der-waals | TM6 | R | 228 | 6x25 | G.h4s6 | R | 337 | G.h4s6.19 |
Hydrophobic | TM7 | R | 295 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | R | 295 | 7x56 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | V | 133 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | V | 133 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | TM5 | Y | 211 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL3 | H | 222 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | H | 222 | - | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | ICL3 | H | 222 | - | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | ICL3 | V | 223 | - | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | ICL3 | V | 223 | - | G.S6 | F | 340 | G.S6.02 |
Polar | TM6 | S | 235 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | S | 235 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | S | 235 | 6x32 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL3 | V | 223 | - | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | ICL3 | V | 223 | - | G.S6 | L | 339 | G.S6.01 |
Polar | TM2 | Q | 62 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | Q | 62 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM3 | V | 130 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | H | 136 | 34x53 | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | ICL2 | H | 136 | 34x53 | G.hns1 | D | 39 | G.hns1.01 |
Van-der-waals | ICL2 | H | 136 | 34x53 | G.hns1 | D | 39 | G.hns1.01 |
Ionic | TM5 | R | 215 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 215 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 215 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 215 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | ICL2 | S | 137 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | S | 137 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM6 | C | 225 | 6x22 | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | TM6 | C | 225 | 6x22 | G.h4s6 | T | 321 | G.h4s6.03 |
Polar | TM3 | R | 126 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | R | 126 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | I | 208 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | ICL2 | H | 136 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | H | 136 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Polar | H8 | D | 296 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | D | 296 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | D | 296 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | R | 138 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | R | 138 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | TM6 | T | 232 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | T | 232 | 6x29 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | T | 232 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | T | 232 | 6x29 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | L | 135 | 34x52 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | V | 133 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | R | 138 | 34x55 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | R | 138 | 34x55 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | TM5 | M | 219 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM5 | M | 219 | 5x72 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 135 | 34x52 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | L | 135 | 34x52 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | M | 219 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM5 | M | 219 | 5x72 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | ICL2 | H | 136 | 34x53 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | H | 136 | 34x53 | G.S1 | L | 43 | G.S1.02 |
Polar | TM3 | R | 126 | 3x50 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | R | 215 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | R | 215 | 5x68 | G.H5 | L | 364 | G.H5.16 |