G12 - LPA3 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 15.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 P 234 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 S 130 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 130 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 134 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 R 135 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 135 34x51 G.H5 I 370 G.H5.15
Hydrophobic TM6 L 237 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 L 237 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 131 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 131 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM7 Y 293 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 293 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL3 H 223 - G.S6 F 347 G.S6.02
Van-der-waals ICL3 H 223 - G.S6 F 347 G.S6.02
Hydrophobic TM5 L 220 5x72 G.H5 F 361 G.H5.06
Hydrophobic TM6 L 237 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 136 34x52 G.S1 V 58 G.S1.02
Hydrophobic TM3 I 131 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 V 136 34x52 G.h2s4 T 246 G.h2s4.05
Polar ICL3 T 224 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 T 224 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 T 224 - G.S6 H 348 G.S6.03
Hydrophobic TM3 R 127 3x50 G.H5 M 379 G.H5.24
Van-der-waals TM3 R 127 3x50 G.H5 M 379 G.H5.24
Polar TM6 G 226 6x22 G.H4 D 336 G.H4.16
Van-der-waals TM6 G 226 6x22 G.H4 D 336 G.H4.16
Polar TM3 R 127 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 127 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 127 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 M 134 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 M 134 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL3 S 225 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 T 224 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 T 224 - G.S6 L 346 G.S6.01
Hydrophobic TM6 S 227 6x23 G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 V 136 34x52 G.H5 I 370 G.H5.15
Van-der-waals ICL2 V 136 34x52 G.H5 I 370 G.H5.15
Polar ICL2 S 138 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 S 138 34x54 G.hns1 R 55 G.hns1.02
Polar TM5 T 217 5x69 G.H5 D 368 G.H5.13
Hydrophobic TM5 V 219 5x71 G.H5 H 364 G.H5.09
Van-der-waals TM5 V 219 5x71 G.H5 H 364 G.H5.09
Polar ICL2 L 140 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 L 140 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 V 213 5x65 G.H5 L 375 G.H5.20
Polar TM6 R 230 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM6 R 230 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 R 230 6x26 G.H5 Q 372 G.H5.17
Polar TM3 S 130 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 130 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 130 3x53 G.H5 N 374 G.H5.19
Polar ICL2 V 136 34x52 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 131 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL3 T 224 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 224 - G.h4s6 P 345 G.h4s6.20
Hydrophobic ICL2 M 134 34x50 G.S3 I 221 G.S3.01
Hydrophobic TM7 K 296 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 K 296 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM2 F 65 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM2 Y 66 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 Y 66 2x40 G.H5 L 380 G.H5.25
Polar ICL3 S 225 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 S 225 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 S 225 - G.S6 H 348 G.S6.03
Hydrophobic TM5 L 220 5x72 G.H5 A 365 G.H5.10
Polar TM6 S 227 6x23 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 S 227 6x23 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 S 227 6x23 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM5 V 213 5x65 G.H5 L 371 G.H5.16
Hydrophobic TM5 K 216 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 K 216 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM6 R 230 6x26 G.h4s6 K 344 G.h4s6.19
Aromatic ICL3 H 223 - G.H5 F 361 G.H5.06
Hydrophobic ICL3 H 223 - G.H5 F 361 G.H5.06
Van-der-waals ICL3 H 223 - G.H5 F 361 G.H5.06
Hydrophobic TM6 L 237 6x33 G.H5 Q 381 G.H5.26
Van-der-waals TM6 L 237 6x33 G.H5 Q 381 G.H5.26
Polar TM5 K 216 5x68 G.H5 H 364 G.H5.09
Aromatic TM5 K 216 5x68 G.H5 H 364 G.H5.09
Van-der-waals TM5 K 216 5x68 G.H5 H 364 G.H5.09
Polar ICL3 H 223 - G.S6 H 349 G.S6.04
Aromatic ICL3 H 223 - G.S6 H 349 G.S6.04
Hydrophobic ICL3 H 223 - G.S6 H 349 G.S6.04
Hydrophobic TM6 V 241 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 241 6x37 G.H5 M 379 G.H5.24
Polar ICL3 S 225 - G.h4s6 R 339 G.h4s6.08
Van-der-waals ICL3 S 225 - G.h4s6 R 339 G.h4s6.08
Polar TM5 Y 212 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM5 Y 212 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 Y 212 5x64 G.H5 K 367 G.H5.12
Hydrophobic TM2 L 69 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 L 69 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM6 R 230 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 R 230 6x26 G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 T 224 - G.S6 F 347 G.S6.02
Hydrophobic TM5 L 220 5x72 G.H5 D 368 G.H5.13
Van-der-waals TM5 L 220 5x72 G.H5 D 368 G.H5.13
Hydrophobic ICL2 M 134 34x50 G.H5 F 363 G.H5.08
Polar ICL2 H 137 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 137 34x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 137 34x53 G.hns1 R 55 G.hns1.02
Polar TM6 S 227 6x23 G.h4s6 R 342 G.h4s6.11
Van-der-waals TM6 S 227 6x23 G.h4s6 R 342 G.h4s6.11
Polar ICL3 H 223 - G.S6 H 348 G.S6.03
Hydrophobic ICL3 H 223 - G.S6 H 348 G.S6.03
Van-der-waals ICL3 H 223 - G.S6 H 348 G.S6.03
Hydrophobic TM5 Y 212 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 220 5x72 G.S6 F 347 G.S6.02
Hydrophobic TM2 F 65 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 65 2x39 G.H5 I 378 G.H5.23
Polar ICL3 S 225 - G.S6 L 346 G.S6.01
Van-der-waals ICL3 S 225 - G.S6 L 346 G.S6.01
Hydrophobic TM6 S 227 6x23 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 K 216 5x68 G.H5 L 371 G.H5.16
Polar ICL2 R 135 34x51 G.H5 N 374 G.H5.19
Van-der-waals ICL2 R 135 34x51 G.H5 N 374 G.H5.19
Polar H8 D 297 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 D 297 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 D 297 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 136 34x52 G.S1 L 57 G.S1.01
Hydrophobic TM5 L 220 5x72 G.H5 H 364 G.H5.09
Van-der-waals TM5 L 220 5x72 G.H5 H 364 G.H5.09
Hydrophobic ICL3 S 225 - G.H4 V 332 G.H4.12