G12 - LPA4 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 147 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 147 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 147 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 L 237 - G.H5 L 375 G.H5.20
Van-der-waals ICL3 L 237 - G.H5 L 375 G.H5.20
Polar TM6 Q 239 6x25 G.S6 L 346 G.S6.01
Hydrophobic TM6 Q 239 6x25 G.S6 L 346 G.S6.01
Hydrophobic TM6 M 250 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 M 250 6x36 G.H5 I 378 G.H5.23
Polar C-term F 370 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term F 370 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term F 370 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term S 368 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM6 N 243 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 N 243 6x29 G.H5 M 379 G.H5.24
Polar ICL2 R 147 34x54 G.S1 L 57 G.S1.01
Hydrophobic TM3 A 139 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 I 378 G.H5.23
Hydrophobic TM6 I 240 6x26 G.H5 Q 372 G.H5.17
Van-der-waals TM6 I 240 6x26 G.H5 Q 372 G.H5.17
Hydrophobic C-term F 370 - H.HA K 114 H.HA.28
Van-der-waals C-term F 370 - H.HA K 114 H.HA.28
Hydrophobic ICL2 F 144 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 144 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL1 M 68 12x48 G.H5 L 380 G.H5.25
Van-der-waals ICL1 M 68 12x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 I 240 6x26 G.H5 D 368 G.H5.13
Polar C-term S 368 - H.HA K 114 H.HA.28
Van-der-waals C-term S 368 - H.HA K 114 H.HA.28
Polar C-term S 368 - H.HA D 110 H.HA.24
Hydrophobic C-term S 368 - H.HA D 110 H.HA.24
Van-der-waals C-term S 368 - H.HA D 110 H.HA.24
Hydrophobic TM6 Q 239 6x25 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 Q 239 6x25 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM6 V 247 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 247 6x33 G.H5 M 379 G.H5.24
Polar TM3 A 139 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 374 G.H5.19
Aromatic ICL2 F 144 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 144 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 144 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL3 T 236 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 T 236 - G.H5 D 368 G.H5.13
Hydrophobic TM2 A 75 2x40 G.H5 L 380 G.H5.25
Hydrophobic C-term F 370 - H.HA A 111 H.HA.25
Van-der-waals C-term F 370 - H.HA A 111 H.HA.25
Hydrophobic ICL2 F 144 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 F 144 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 F 144 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 144 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM6 K 246 6x32 G.H5 M 379 G.H5.24
Hydrophobic H8 L 315 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 L 315 8x47 G.H5 M 379 G.H5.24
Polar TM2 E 73 2x38 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 72 2x37 G.H5 L 380 G.H5.25
Van-der-waals TM2 S 72 2x37 G.H5 L 380 G.H5.25
Polar ICL2 S 146 34x53 G.H5 N 374 G.H5.19
Polar ICL2 P 143 34x50 G.H5 N 374 G.H5.19
Polar C-term S 368 - H.HA A 111 H.HA.25
Hydrophobic C-term S 368 - H.HA A 111 H.HA.25
Van-der-waals C-term S 368 - H.HA A 111 H.HA.25
Polar H8 E 316 8x48 G.H5 Q 381 G.H5.26
Hydrophobic H8 E 316 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 E 316 8x48 G.H5 Q 381 G.H5.26
Polar H8 S 317 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 S 317 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 S 317 8x49 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 143 34x50 G.H5 L 371 G.H5.16
Ionic C-term E 367 - H.HA K 114 H.HA.28
Polar C-term E 367 - H.HA K 114 H.HA.28
Hydrophobic C-term E 367 - H.HA K 114 H.HA.28
Van-der-waals C-term E 367 - H.HA K 114 H.HA.28
Hydrophobic TM3 I 140 3x54 G.H5 L 375 G.H5.20
Hydrophobic H8 L 315 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 L 315 8x47 G.H5 L 380 G.H5.25
Hydrophobic TM2 I 78 2x43 G.H5 L 380 G.H5.25
Van-der-waals TM2 I 78 2x43 G.H5 L 380 G.H5.25
Hydrophobic TM1 F 64 1x57 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 144 34x51 G.S3 F 223 G.S3.03
Polar TM6 Q 239 6x25 G.S6 F 347 G.S6.02
Hydrophobic TM6 Q 239 6x25 G.S6 F 347 G.S6.02
Van-der-waals TM6 Q 239 6x25 G.S6 F 347 G.S6.02
Hydrophobic C-term L 366 - H.HA R 106 H.HA.20
Van-der-waals C-term L 366 - H.HA R 106 H.HA.20
Polar ICL2 R 147 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 F 144 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 144 34x51 G.S3 I 221 G.S3.01
Hydrophobic C-term F 370 - H.HD E 172 H.HD.12
Van-der-waals C-term F 370 - H.HD E 172 H.HD.12
Hydrophobic ICL2 T 148 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 T 148 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 T 148 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 T 148 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 T 148 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic C-term F 370 - H.hdhe F 173 H.hdhe.01
Hydrophobic TM3 I 140 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 144 34x51 G.H5 V 366 G.H5.11
Polar TM2 S 72 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 72 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 72 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM3 R 136 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 136 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 143 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 143 34x50 G.H5 K 367 G.H5.12
Hydrophobic C-term F 370 - H.HA L 115 H.HA.29
Van-der-waals C-term F 370 - H.HA L 115 H.HA.29
Polar H8 S 317 8x49 G.H5 Q 381 G.H5.26
Hydrophobic H8 S 317 8x49 G.H5 Q 381 G.H5.26
Ionic ICL2 R 150 34x57 G.H5 D 377 G.H5.22
Polar ICL2 R 150 34x57 G.H5 D 377 G.H5.22
Van-der-waals ICL2 R 150 34x57 G.H5 D 377 G.H5.22
Polar TM2 T 74 2x39 G.H5 D 377 G.H5.22
Hydrophobic ICL3 T 236 - G.H5 L 371 G.H5.16
Polar ICL2 R 150 34x57 G.H5 N 374 G.H5.19
Hydrophobic ICL3 L 237 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 L 237 - G.H5 L 371 G.H5.16
Polar C-term T 369 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term T 369 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term T 369 - G.s4h3 R 265 G.s4h3.12
Polar C-term S 368 - H.HA V 107 H.HA.21
Hydrophobic C-term S 368 - H.HA V 107 H.HA.21
Van-der-waals C-term S 368 - H.HA V 107 H.HA.21
Hydrophobic TM3 I 140 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 140 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 R 147 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 247 6x33 G.H5 L 375 G.H5.20
Hydrophobic C-term L 366 - H.HA K 103 H.HA.17
Hydrophobic ICL2 P 143 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 143 34x50 G.H5 I 370 G.H5.15
Polar H8 S 317 8x49 G.H5 M 379 G.H5.24
Hydrophobic TM4 T 151 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 T 151 4x38 G.hns1 R 55 G.hns1.02
Hydrophobic C-term E 367 - H.HA D 110 H.HA.24
Van-der-waals C-term E 367 - H.HA D 110 H.HA.24