Gi3 - LPA5 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL2 R 130 34x54 G.S1 E 33 G.S1.01
Polar TM6 K 231 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM6 K 231 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 231 6x32 G.H5 Y 354 G.H5.26
Polar TM3 D 118 3x49 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 126 34x50 G.H5 I 343 G.H5.15
Ionic ICL2 R 133 34x57 G.H5 E 350 G.H5.22
Polar ICL2 R 133 34x57 G.H5 E 350 G.H5.22
Polar TM4 R 134 4x38 G.HN R 24 G.HN.48
Hydrophobic TM4 R 134 4x38 G.HN R 24 G.HN.48
Van-der-waals TM4 R 134 4x38 G.HN R 24 G.HN.48
Hydrophobic TM3 I 123 3x54 G.H5 I 344 G.H5.16
Ionic TM4 R 136 4x40 G.HN D 20 G.HN.44
Polar TM4 R 136 4x40 G.HN D 20 G.HN.44
Van-der-waals TM4 R 136 4x40 G.HN D 20 G.HN.44
Polar ICL3 T 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL3 T 224 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 T 224 - G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 L 127 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 L 127 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM6 L 236 6x37 G.H5 L 353 G.H5.25
Polar H8 A 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 A 301 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 A 301 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL2 H 131 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 H 131 34x55 G.HN E 28 G.HN.52
Polar TM4 R 134 4x38 G.HN G 27 G.HN.51
Hydrophobic TM4 R 134 4x38 G.HN G 27 G.HN.51
Van-der-waals TM4 R 134 4x38 G.HN G 27 G.HN.51
Polar ICL2 R 133 34x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 133 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 133 34x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 C 351 G.H5.23
Polar ICL2 R 130 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 130 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 130 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 126 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 119 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 119 3x50 G.H5 L 353 G.H5.25
Polar TM6 T 232 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 232 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 232 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 L 353 G.H5.25
Polar TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 119 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 127 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 127 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM2 V 57 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 V 57 2x39 G.H5 C 351 G.H5.23
Polar TM6 R 228 6x29 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 228 6x29 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 228 6x29 G.h4s6 D 315 G.h4s6.09
Ionic TM4 R 134 4x38 G.HN E 28 G.HN.52
Polar TM4 R 134 4x38 G.HN E 28 G.HN.52
Hydrophobic TM4 R 134 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 R 134 4x38 G.HN E 28 G.HN.52
Hydrophobic ICL2 L 127 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 127 34x51 G.S3 L 194 G.S3.01
Hydrophobic ICL2 P 126 34x50 G.H5 T 340 G.H5.12
Polar TM6 R 228 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM6 R 228 6x29 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 228 6x29 G.H5 Y 354 G.H5.26
Polar TM2 S 55 2x37 G.H5 E 350 G.H5.22
Polar TM6 R 228 6x29 G.h4s6 T 316 G.h4s6.10
Hydrophobic TM6 R 228 6x29 G.h4s6 T 316 G.h4s6.10
Van-der-waals TM6 R 228 6x29 G.h4s6 T 316 G.h4s6.10
Polar TM3 A 122 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 122 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 122 3x53 G.H5 N 347 G.H5.19
Polar ICL2 R 133 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 133 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 235 6x36 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 123 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 123 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 232 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 T 232 6x33 G.H5 L 348 G.H5.20
Polar TM7 S 300 7x56 G.H5 G 352 G.H5.24