G12 -
BLT1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | P | 122 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL3 | F | 213 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | F | 213 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM2 | M | 56 | 2x42 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM2 | M | 56 | 2x42 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | Q | 126 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | Q | 126 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | C-term | R | 317 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | C-term | R | 317 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 119 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL3 | F | 213 | - | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | ICL3 | F | 213 | - | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | C-term | S | 314 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Van-der-waals | C-term | S | 314 | - | G.h2s4 | D | 243 | G.h2s4.02 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | ICL2 | K | 127 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | K | 127 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | K | 127 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | L | 371 | G.H5.16 |
Polar | TM5 | R | 211 | 5x68 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM5 | R | 211 | 5x68 | G.H5 | K | 367 | G.H5.12 |
Polar | C-term | L | 321 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | L | 321 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | L | 321 | - | G.H3 | K | 284 | G.H3.16 |
Aromatic | ICL2 | F | 123 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | F | 123 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | T | 308 | - | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | C-term | T | 308 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM3 | M | 111 | 3x46 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | M | 111 | 3x46 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM3 | D | 114 | 3x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | F | 123 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | R | 129 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | R | 129 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | S | 310 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | C-term | S | 310 | - | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | C-term | S | 310 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM7 | A | 288 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | T | 219 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 219 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | C-term | T | 308 | - | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | C-term | T | 308 | - | G.H5 | L | 380 | G.H5.25 |
Ionic | TM5 | R | 211 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 211 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | R | 211 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 211 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | L | 222 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | L | 222 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | S | 310 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | C-term | S | 310 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | F | 123 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | ICL3 | F | 213 | - | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | ICL3 | F | 213 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | R | 211 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | R | 211 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Polar | TM3 | A | 118 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | F | 123 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Polar | C-term | R | 317 | - | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | C-term | R | 317 | - | G.h3s5 | N | 288 | G.h3s5.02 |
Van-der-waals | C-term | R | 317 | - | G.h3s5 | N | 288 | G.h3s5.02 |
Hydrophobic | TM5 | L | 208 | 5x65 | G.H5 | M | 379 | G.H5.24 |
Polar | TM2 | T | 53 | 2x39 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM2 | T | 53 | 2x39 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM2 | T | 53 | 2x39 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | L | 304 | - | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | C-term | L | 304 | - | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM5 | L | 208 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 208 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | ICL2 | R | 129 | 34x57 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | R | 129 | 34x57 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | ICL2 | R | 129 | 34x57 | G.H5 | Q | 381 | G.H5.26 |
Polar | C-term | S | 320 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | C-term | S | 320 | - | G.H3 | K | 284 | G.H3.16 |
Van-der-waals | C-term | S | 320 | - | G.H3 | K | 284 | G.H3.16 |
Hydrophobic | TM6 | V | 223 | 6x37 | G.H5 | M | 379 | G.H5.24 |