G11 -
BLT2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | C-term | G | 346 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | G | 346 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | G | 346 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | ICL2 | F | 127 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | F | 127 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | TM4 | S | 134 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM4 | S | 134 | 4x38 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM6 | L | 225 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | V | 123 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | V | 123 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | L | 333 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | C-term | L | 333 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | L | 333 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | ICL2 | R | 131 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | R | 131 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Polar | TM3 | R | 119 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | R | 119 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | P | 331 | - | G.H5 | R | 338 | G.H5.05 |
Hydrophobic | C-term | P | 331 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | C-term | P | 331 | - | G.H5 | R | 338 | G.H5.05 |
Hydrophobic | C-term | M | 325 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | C-term | M | 325 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | C-term | E | 350 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | C-term | E | 326 | - | G.H5 | F | 339 | G.H5.06 |
Polar | TM6 | V | 222 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | V | 222 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | V | 222 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Polar | ICL1 | R | 52 | 12x51 | G.h2s4 | N | 222 | G.h2s4.03 |
Van-der-waals | ICL1 | R | 52 | 12x51 | G.h2s4 | N | 222 | G.h2s4.03 |
Hydrophobic | C-term | L | 327 | - | G.H5 | A | 343 | G.H5.10 |
Van-der-waals | C-term | L | 327 | - | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | TM6 | V | 226 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | F | 127 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | F | 127 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | L | 333 | - | G.S2 | L | 196 | G.S2.08 |
Van-der-waals | C-term | L | 333 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | C-term | G | 337 | - | G.h1ha | G | 64 | G.h1ha.01 |
Van-der-waals | C-term | G | 337 | - | G.h1ha | G | 64 | G.h1ha.01 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Polar | ICL2 | P | 130 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | P | 130 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | P | 130 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | A | 129 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | A | 129 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | L | 327 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | C-term | L | 327 | - | G.S6 | Y | 325 | G.S6.02 |
Ionic | C-term | D | 344 | - | G.H1 | K | 57 | G.H1.06 |
Van-der-waals | C-term | D | 344 | - | G.H1 | K | 57 | G.H1.06 |
Hydrophobic | C-term | L | 327 | - | G.H5 | A | 342 | G.H5.09 |
Van-der-waals | C-term | L | 327 | - | G.H5 | A | 342 | G.H5.09 |
Polar | C-term | M | 325 | - | G.S6 | I | 324 | G.S6.01 |
Van-der-waals | C-term | M | 325 | - | G.S6 | I | 324 | G.S6.01 |
Polar | C-term | D | 344 | - | G.h1ha | Y | 67 | G.h1ha.04 |
Hydrophobic | C-term | D | 344 | - | G.h1ha | Y | 67 | G.h1ha.04 |
Van-der-waals | C-term | D | 344 | - | G.h1ha | Y | 67 | G.h1ha.04 |
Hydrophobic | C-term | P | 345 | - | H.HA | D | 71 | H.HA.03 |
Van-der-waals | C-term | P | 345 | - | H.HA | D | 71 | H.HA.03 |
Hydrophobic | C-term | V | 335 | - | G.H1 | H | 63 | G.H1.12 |
Van-der-waals | C-term | V | 335 | - | G.H1 | H | 63 | G.H1.12 |
Polar | C-term | T | 329 | - | G.H5 | E | 335 | G.H5.02 |
Hydrophobic | C-term | T | 329 | - | G.H5 | E | 335 | G.H5.02 |
Van-der-waals | C-term | T | 329 | - | G.H5 | E | 335 | G.H5.02 |
Van-der-waals | C-term | G | 347 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | G | 348 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | G | 348 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | TM3 | V | 123 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | V | 123 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | C-term | N | 342 | - | G.S2 | I | 190 | G.S2.02 |
Polar | ICL2 | R | 133 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | R | 133 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | R | 133 | 34x57 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | C-term | L | 333 | - | G.H5 | I | 337 | G.H5.04 |
Hydrophobic | C-term | V | 335 | - | G.S2 | F | 194 | G.S2.06 |
Hydrophobic | ICL2 | A | 129 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | F | 127 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | F | 127 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM6 | L | 225 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | L | 225 | 6x36 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | V | 336 | - | G.S2 | D | 195 | G.S2.07 |
Hydrophobic | C-term | V | 336 | - | G.S2 | D | 195 | G.S2.07 |
Van-der-waals | C-term | V | 336 | - | G.S2 | D | 195 | G.S2.07 |
Hydrophobic | C-term | L | 333 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | TM6 | V | 222 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | V | 222 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | T | 324 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | C-term | T | 324 | - | G.H4 | V | 314 | G.H4.16 |
Polar | TM7 | L | 295 | 7x60 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM7 | L | 295 | 7x60 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | L | 295 | 7x60 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | K | 351 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | K | 351 | - | G.S2 | I | 189 | G.S2.01 |
Polar | TM3 | A | 122 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Aromatic | ICL2 | F | 127 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | F | 127 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | F | 127 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | C-term | T | 329 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | T | 329 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | T | 329 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | C-term | T | 329 | - | G.H5 | R | 338 | G.H5.05 |
Hydrophobic | TM2 | A | 57 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Ionic | C-term | K | 351 | - | G.S2 | E | 191 | G.S2.03 |
Polar | C-term | K | 351 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | K | 351 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | K | 351 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | ICL2 | F | 127 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | F | 127 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | V | 123 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | TM7 | G | 293 | 7x58 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | G | 293 | 7x58 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | M | 325 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | C-term | L | 333 | - | G.H5 | R | 338 | G.H5.05 |
Van-der-waals | C-term | L | 333 | - | G.H5 | R | 338 | G.H5.05 |
Polar | TM3 | Q | 118 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | Q | 118 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | Q | 118 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | M | 349 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | M | 349 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | C-term | V | 335 | - | G.S2 | L | 196 | G.S2.08 |
Van-der-waals | C-term | V | 335 | - | G.S2 | L | 196 | G.S2.08 |
Hydrophobic | TM6 | V | 222 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | V | 222 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM7 | A | 292 | 7x57 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | A | 292 | 7x57 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 126 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | P | 345 | - | H.HA | G | 74 | H.HA.06 |
Hydrophobic | C-term | D | 344 | - | H.HA | F | 75 | H.HA.07 |
Van-der-waals | C-term | D | 344 | - | H.HA | F | 75 | H.HA.07 |
Ionic | C-term | D | 344 | - | G.H1 | R | 60 | G.H1.09 |
Polar | C-term | D | 344 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | D | 344 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | TM6 | R | 221 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 221 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | L | 327 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | W | 213 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | W | 213 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | A | 122 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 122 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM3 | R | 119 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 119 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 119 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL2 | P | 126 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | P | 126 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | H | 218 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | H | 218 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Ionic | ICL2 | R | 133 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Polar | ICL2 | R | 133 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | R | 133 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | ICL2 | R | 133 | 34x57 | G.H5 | E | 355 | G.H5.22 |
Polar | C-term | M | 349 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | M | 349 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | L | 333 | - | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | C-term | L | 333 | - | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | TM5 | L | 208 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | G | 337 | - | G.h1ha | A | 65 | G.h1ha.02 |
Hydrophobic | C-term | G | 337 | - | G.h1ha | A | 65 | G.h1ha.02 |
Hydrophobic | ICL3 | W | 213 | - | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | ICL3 | W | 213 | - | G.H5 | L | 353 | G.H5.20 |
Polar | ICL3 | W | 213 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL3 | W | 213 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL3 | W | 213 | - | G.H5 | Q | 350 | G.H5.17 |
Polar | C-term | M | 325 | - | G.S6 | S | 326 | G.S6.03 |
Hydrophobic | C-term | G | 348 | - | G.S2 | I | 190 | G.S2.02 |
Polar | C-term | P | 345 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | C-term | P | 345 | - | H.HA | F | 75 | H.HA.07 |
Van-der-waals | C-term | P | 345 | - | H.HA | F | 75 | H.HA.07 |
Polar | C-term | G | 337 | - | G.H1 | H | 63 | G.H1.12 |
Hydrophobic | TM3 | R | 119 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | F | 127 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Hydrophobic | C-term | L | 327 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | L | 327 | - | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | C-term | V | 335 | - | G.S2 | D | 195 | G.S2.07 |
Van-der-waals | C-term | V | 335 | - | G.S2 | D | 195 | G.S2.07 |
Polar | C-term | K | 334 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | C-term | K | 334 | - | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | TM7 | D | 294 | 7x59 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | D | 294 | 7x59 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | G | 347 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | T | 330 | - | G.H5 | R | 338 | G.H5.05 |
Polar | ICL2 | R | 131 | 34x55 | G.s2s3 | N | 198 | G.s2s3.02 |