G15 - MAS1L complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic C-term T 378 - G.h1ha G 67 G.h1ha.01
Polar TM2 N 106 2x37 G.H5 E 370 G.H5.22
Van-der-waals TM2 N 106 2x37 G.H5 E 370 G.H5.22
Polar TM6 R 261 6x32 G.H5 L 373 G.H5.25
Polar TM3 E 170 3x49 G.H5 Y 367 G.H5.19
Hydrophobic C-term V 376 - G.H1 R 63 G.H1.09
Hydrophobic ICL2 I 179 34x51 G.S1 L 43 G.S1.02
Hydrophobic TM3 V 175 3x54 G.H5 L 368 G.H5.20
Ionic H8 K 322 8x51 G.H5 D 369 G.H5.21
Polar H8 K 322 8x51 G.H5 D 369 G.H5.21
Hydrophobic H8 K 322 8x51 G.H5 D 369 G.H5.21
Van-der-waals H8 K 322 8x51 G.H5 D 369 G.H5.21
Polar H8 R 321 8x50 G.H5 L 374 G.H5.26
Van-der-waals H8 R 321 8x50 G.H5 L 374 G.H5.26
Hydrophobic TM3 C 174 3x53 G.H5 Y 367 G.H5.19
Van-der-waals TM3 C 174 3x53 G.H5 Y 367 G.H5.19
Polar C-term R 373 - G.S2 C 196 G.S2.05
Hydrophobic C-term R 373 - G.S2 C 196 G.S2.05
Van-der-waals C-term R 373 - G.S2 C 196 G.S2.05
Hydrophobic ICL2 P 178 34x50 G.H5 V 363 G.H5.15
Van-der-waals ICL2 P 178 34x50 G.H5 V 363 G.H5.15
Polar C-term V 374 - G.S2 C 196 G.S2.05
Van-der-waals C-term V 374 - G.S2 C 196 G.S2.05
Hydrophobic TM3 V 175 3x54 G.H5 L 364 G.H5.16
Hydrophobic C-term V 376 - G.S2 F 197 G.S2.06
Hydrophobic ICL2 R 182 34x54 G.S1 L 43 G.S1.02
Hydrophobic C-term T 378 - G.S2 S 198 G.S2.07
Van-der-waals C-term T 378 - G.S2 S 198 G.S2.07
Hydrophobic ICL2 I 179 34x51 G.S3 T 202 G.S3.01
Van-der-waals ICL2 I 179 34x51 G.S3 T 202 G.S3.01
Hydrophobic ICL2 C 183 34x55 G.S1 L 43 G.S1.02
Van-der-waals ICL2 C 183 34x55 G.S1 L 43 G.S1.02
Hydrophobic ICL2 I 179 34x51 G.H5 F 356 G.H5.08
Van-der-waals ICL2 I 179 34x51 G.H5 F 356 G.H5.08
Hydrophobic ICL2 P 178 34x50 G.H5 R 360 G.H5.12
Van-der-waals ICL2 P 178 34x50 G.H5 R 360 G.H5.12
Polar C-term D 375 - G.S2 C 196 G.S2.05
Hydrophobic C-term D 375 - G.S2 C 196 G.S2.05
Van-der-waals C-term D 375 - G.S2 C 196 G.S2.05
Hydrophobic ICL2 R 182 34x54 G.H5 V 363 G.H5.15
Hydrophobic TM2 Y 108 2x39 G.H5 I 371 G.H5.23
Van-der-waals TM2 Y 108 2x39 G.H5 I 371 G.H5.23
Ionic H8 R 324 8x53 G.h4s6 E 328 G.h4s6.10
Polar H8 R 324 8x53 G.h4s6 E 328 G.h4s6.10
Hydrophobic H8 R 324 8x53 G.h4s6 E 328 G.h4s6.10
Van-der-waals H8 R 324 8x53 G.h4s6 E 328 G.h4s6.10
Hydrophobic C-term V 376 - G.h1ha G 67 G.h1ha.01
Hydrophobic ICL2 I 179 34x51 G.H5 R 360 G.H5.12
Hydrophobic TM3 R 171 3x50 G.H5 L 373 G.H5.25
Hydrophobic C-term T 378 - G.H1 H 66 G.H1.12
Van-der-waals C-term T 378 - G.H1 H 66 G.H1.12
Hydrophobic H8 G 318 8x47 G.H5 N 372 G.H5.24
Van-der-waals H8 G 318 8x47 G.H5 N 372 G.H5.24
Hydrophobic C-term R 373 - G.S3 R 205 G.S3.04
Van-der-waals C-term R 373 - G.S3 R 205 G.S3.04
Polar ICL2 C 183 34x55 G.hns1 R 40 G.hns1.02
Hydrophobic ICL2 C 183 34x55 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 C 183 34x55 G.hns1 R 40 G.hns1.02
Polar ICL2 Y 181 34x53 G.H5 Y 367 G.H5.19
Aromatic ICL2 Y 181 34x53 G.H5 Y 367 G.H5.19
Hydrophobic ICL2 Y 181 34x53 G.H5 Y 367 G.H5.19
Van-der-waals ICL2 Y 181 34x53 G.H5 Y 367 G.H5.19
Polar ICL2 H 184 34x56 G.s2s3 K 201 G.s2s3.02
Hydrophobic ICL2 H 184 34x56 G.s2s3 K 201 G.s2s3.02
Van-der-waals ICL2 H 184 34x56 G.s2s3 K 201 G.s2s3.02
Polar C-term H 372 - G.S2 E 194 G.S2.03
Van-der-waals C-term H 372 - G.S2 E 194 G.S2.03
Hydrophobic C-term R 373 - G.S2 E 194 G.S2.03
Van-der-waals C-term R 373 - G.S2 E 194 G.S2.03
Hydrophobic ICL2 C 183 34x55 G.hns1 G 41 G.hns1.03
Polar C-term V 374 - G.S2 E 194 G.S2.03
Van-der-waals C-term V 374 - G.S2 E 194 G.S2.03
Polar ICL2 R 182 34x54 G.hns1 R 40 G.hns1.02
Van-der-waals ICL2 R 182 34x54 G.hns1 R 40 G.hns1.02
Hydrophobic TM6 A 264 6x35 G.H5 L 373 G.H5.25
Van-der-waals TM6 A 264 6x35 G.H5 L 373 G.H5.25
Polar C-term V 376 - G.S2 C 196 G.S2.05
Van-der-waals C-term V 376 - G.S2 C 196 G.S2.05
Hydrophobic TM6 Q 267 6x38 G.H5 L 373 G.H5.25
Van-der-waals TM6 Q 267 6x38 G.H5 L 373 G.H5.25
Hydrophobic TM6 T 260 6x31 G.H5 L 374 G.H5.26
Van-der-waals TM6 T 260 6x31 G.H5 L 374 G.H5.26
Ionic C-term R 373 - G.S1 E 42 G.S1.01
Polar C-term R 373 - G.S1 E 42 G.S1.01
Hydrophobic C-term R 373 - G.S1 E 42 G.S1.01
Van-der-waals C-term R 373 - G.S1 E 42 G.S1.01
Polar H8 R 321 8x50 G.h4s6 R 335 G.h4s6.17
Hydrophobic H8 R 321 8x50 G.h4s6 R 335 G.h4s6.17
Van-der-waals H8 R 321 8x50 G.h4s6 R 335 G.h4s6.17
Hydrophobic C-term V 376 - G.S2 Y 195 G.S2.04
Hydrophobic TM3 C 174 3x53 G.H5 L 364 G.H5.16
Hydrophobic ICL2 P 178 34x50 G.H5 L 364 G.H5.16
Hydrophobic C-term V 374 - G.S2 Y 195 G.S2.04
Van-der-waals C-term V 374 - G.S2 Y 195 G.S2.04
Hydrophobic ICL2 R 182 34x54 G.h2s4 I 227 G.h2s4.05
Van-der-waals ICL2 R 182 34x54 G.h2s4 I 227 G.h2s4.05
Hydrophobic TM3 R 171 3x50 G.H5 I 371 G.H5.23
Hydrophobic TM6 T 260 6x31 G.H5 L 373 G.H5.25
Van-der-waals TM6 T 260 6x31 G.H5 L 373 G.H5.25
Hydrophobic TM5 F 250 5x63 G.H5 L 368 G.H5.20
Polar C-term E 377 - G.h1ha A 68 G.h1ha.02
Hydrophobic C-term E 377 - G.h1ha A 68 G.h1ha.02
Van-der-waals C-term E 377 - G.h1ha A 68 G.h1ha.02
Hydrophobic H8 R 324 8x53 G.h4s6 K 332 G.h4s6.14
Van-der-waals H8 R 324 8x53 G.h4s6 K 332 G.h4s6.14