GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 75.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM7 | Y | 314 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM7 | Y | 314 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Polar | ICL2 | Y | 181 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | Y | 181 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | Y | 181 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | Q | 362 | - | H.hbhc | E | 119 | H.hbhc.01 |
Polar | C-term | H | 372 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | H | 372 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | C-term | V | 376 | - | G.H2 | H | 218 | G.H2.09 |
Van-der-waals | C-term | V | 376 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | C-term | V | 376 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | TM3 | V | 175 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | V | 175 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | P | 178 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | I | 179 | 34x51 | G.s2s3 | S | 198 | G.s2s3.02 |
Polar | C-term | E | 371 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | E | 371 | - | G.S2 | Y | 192 | G.S2.04 |
Van-der-waals | C-term | E | 371 | - | G.S2 | Y | 192 | G.S2.04 |
Hydrophobic | C-term | V | 374 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | TM3 | V | 175 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM2 | Y | 108 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | C | 183 | 34x55 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | TM4 | K | 187 | 4x39 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | P | 178 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | P | 178 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | R | 182 | 34x54 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | R | 182 | 34x54 | G.H5 | I | 348 | G.H5.15 |
Polar | ICL2 | C | 183 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | C | 183 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | C | 183 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM5 | L | 246 | 5x59 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | R | 261 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | R | 261 | 6x32 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | G | 318 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | G | 318 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | R | 321 | 8x50 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | E | 371 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | E | 371 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | ICL2 | Y | 181 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Polar | TM3 | C | 174 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | C | 174 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | C | 174 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | R | 182 | 34x54 | G.H5 | L | 351 | G.H5.18 |
Van-der-waals | ICL2 | R | 182 | 34x54 | G.H5 | L | 351 | G.H5.18 |
Hydrophobic | TM3 | R | 171 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Ionic | ICL3 | K | 258 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | ICL3 | K | 258 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | ICL3 | K | 258 | - | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM2 | Y | 108 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Polar | TM3 | E | 170 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 170 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 170 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | C | 174 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | K | 258 | - | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | L | 367 | - | H.HA | G | 74 | H.HA.06 |
Polar | TM2 | Y | 108 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | TM2 | Y | 108 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | Y | 108 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | Y | 108 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | V | 262 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | V | 175 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | V | 175 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | P | 178 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Polar | ICL2 | C | 183 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | C | 183 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | C | 183 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | C | 183 | 34x55 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | P | 369 | - | G.H1 | R | 60 | G.H1.09 |
Polar | TM3 | R | 171 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 171 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 171 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | I | 179 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Polar | ICL2 | H | 184 | 34x56 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | ICL2 | H | 184 | 34x56 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | H | 184 | 34x56 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM3 | C | 174 | 3x53 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | L | 368 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | L | 368 | - | G.H1 | R | 60 | G.H1.09 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | TM6 | R | 261 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | R | 261 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 261 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Polar | C-term | V | 374 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | TM6 | V | 265 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | V | 265 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | R | 373 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | ICL2 | I | 179 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | I | 179 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | P | 178 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | P | 178 | 34x50 | G.H5 | I | 348 | G.H5.15 |