Gt2 - MAS1L complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 74.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Y 181 34x53 G.H5 N 347 G.H5.19
Hydrophobic H8 K 322 8x51 G.H5 K 349 G.H5.21
Van-der-waals H8 K 322 8x51 G.H5 K 349 G.H5.21
Polar C-term L 367 - G.H3 S 252 G.H3.11
Hydrophobic TM3 R 171 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 171 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM5 L 246 5x59 G.H5 L 353 G.H5.25
Hydrophobic TM3 V 175 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM2 Y 108 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 Y 108 2x39 G.H5 D 350 G.H5.22
Polar ICL2 C 183 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 C 183 34x55 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 C 183 34x55 G.S3 L 194 G.S3.01
Hydrophobic TM3 C 174 3x53 G.H5 L 348 G.H5.20
Van-der-waals TM3 C 174 3x53 G.H5 L 348 G.H5.20
Polar TM4 K 187 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM4 K 187 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 K 187 4x39 G.HN Q 24 G.HN.48
Hydrophobic ICL2 R 182 34x54 G.H5 I 343 G.H5.15
Ionic ICL2 H 184 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 H 184 34x56 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 H 184 34x56 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 F 250 5x63 G.H5 F 354 G.H5.26
Van-der-waals TM5 F 250 5x63 G.H5 F 354 G.H5.26
Hydrophobic ICL3 K 258 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 K 258 - G.H5 K 345 G.H5.17
Hydrophobic H8 R 321 8x50 G.H5 F 354 G.H5.26
Van-der-waals H8 R 321 8x50 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 261 6x32 G.H5 L 353 G.H5.25
Van-der-waals TM6 R 261 6x32 G.H5 L 353 G.H5.25
Polar ICL2 Y 181 34x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 Y 181 34x53 G.H5 C 351 G.H5.23
Polar TM5 Q 255 5x68 G.h4s6 K 314 G.h4s6.08
Hydrophobic C-term L 367 - G.H3 H 256 G.H3.15
Hydrophobic TM3 V 175 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 V 175 3x54 G.H5 L 348 G.H5.20
Polar TM3 R 171 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 171 3x50 G.H5 C 351 G.H5.23
Polar TM3 C 174 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 C 174 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 C 174 3x53 G.H5 N 347 G.H5.19
Polar ICL2 P 178 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 178 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM6 V 265 6x36 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 265 6x36 G.H5 L 353 G.H5.25
Polar TM2 N 106 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 N 106 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 N 106 2x37 G.H5 D 350 G.H5.22
Polar TM6 R 261 6x32 G.H5 F 354 G.H5.26
Hydrophobic TM6 R 261 6x32 G.H5 F 354 G.H5.26
Van-der-waals TM6 R 261 6x32 G.H5 F 354 G.H5.26
Polar TM2 Y 108 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM2 Y 108 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 Y 108 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 179 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 179 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 I 179 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM6 R 261 6x32 G.H5 G 352 G.H5.24
Hydrophobic TM6 R 261 6x32 G.H5 G 352 G.H5.24
Van-der-waals TM6 R 261 6x32 G.H5 G 352 G.H5.24
Hydrophobic ICL2 P 178 34x50 G.H5 T 340 G.H5.12
Van-der-waals ICL2 P 178 34x50 G.H5 T 340 G.H5.12
Polar H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 G 318 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 G 318 8x47 G.H5 G 352 G.H5.24
Hydrophobic ICL3 K 258 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 K 258 - G.H5 F 354 G.H5.26
Hydrophobic ICL2 P 178 34x50 G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 178 34x50 G.H5 I 344 G.H5.16
Hydrophobic C-term L 368 - G.H3 H 248 G.H3.07
Van-der-waals C-term L 368 - G.H3 H 248 G.H3.07
Polar ICL2 C 183 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 C 183 34x55 G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 C 183 34x55 G.hns1 K 32 G.hns1.03
Hydrophobic C-term P 369 - G.H3 H 248 G.H3.07
Van-der-waals C-term P 369 - G.H3 H 248 G.H3.07
Hydrophobic ICL2 I 179 34x51 G.H5 I 343 G.H5.15
Polar TM5 Q 255 5x68 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 Q 255 5x68 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 Q 255 5x68 G.h4s6 E 318 G.h4s6.12
Ionic TM5 R 249 5x62 G.H5 D 341 G.H5.13
Polar TM5 R 249 5x62 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 249 5x62 G.H5 D 341 G.H5.13
Polar ICL2 H 184 34x56 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 I 179 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 179 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM5 L 246 5x59 G.H5 L 348 G.H5.20
Polar TM5 Q 255 5x68 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM5 Q 255 5x68 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM5 Q 255 5x68 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM5 R 249 5x62 G.H5 I 344 G.H5.16
Van-der-waals TM5 R 249 5x62 G.H5 I 344 G.H5.16
Hydrophobic TM3 C 174 3x53 G.H5 C 351 G.H5.23
Ionic ICL3 K 258 - G.h4s6 E 318 G.h4s6.12
Polar ICL3 K 258 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 K 258 - G.h4s6 E 318 G.h4s6.12
Polar ICL2 R 182 34x54 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 182 34x54 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 182 34x54 G.hns1 A 31 G.hns1.02
Ionic ICL2 R 182 34x54 G.H5 E 346 G.H5.18
Polar ICL2 R 182 34x54 G.H5 E 346 G.H5.18
Van-der-waals ICL2 R 182 34x54 G.H5 E 346 G.H5.18
Hydrophobic ICL3 Q 257 - G.h4s6 D 315 G.h4s6.09
Van-der-waals ICL3 Q 257 - G.h4s6 D 315 G.h4s6.09
Polar TM5 C 253 5x66 G.H5 D 341 G.H5.13
Hydrophobic TM5 C 253 5x66 G.H5 D 341 G.H5.13
Van-der-waals TM5 C 253 5x66 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 178 34x50 G.H5 I 343 G.H5.15