G12 -
MCH1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | A | 309 | - | G.S6 | F | 347 | G.S6.02 |
Polar | ICL2 | R | 224 | 34x57 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM3 | V | 215 | 3x55 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | TM3 | V | 215 | 3x55 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | P | 217 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 217 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | TM4 | K | 225 | 4x38 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM4 | K | 225 | 4x38 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | K | 225 | 4x38 | G.HN | R | 52 | G.HN.52 |
Polar | TM6 | R | 319 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | R | 319 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | R | 319 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Polar | TM6 | S | 315 | 6x25 | G.h4s6 | S | 343 | G.h4s6.12 |
Polar | H8 | C | 384 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | C | 384 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | C | 384 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM2 | I | 151 | 2x43 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | P | 217 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 217 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | I | 218 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | I | 218 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | TM5 | M | 304 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | M | 304 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM2 | P | 147 | 2x39 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM6 | R | 319 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | R | 319 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM5 | S | 307 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL2 | P | 217 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 217 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | H8 | T | 386 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | T | 386 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | R | 322 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL2 | T | 221 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | T | 221 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | T | 221 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM6 | Q | 313 | 6x23 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM6 | Q | 313 | 6x23 | G.h4s6 | K | 344 | G.h4s6.19 |
Van-der-waals | TM6 | Q | 313 | 6x23 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM5 | S | 307 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ICL2 | I | 218 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM6 | Q | 313 | 6x23 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM6 | Q | 313 | 6x23 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 313 | 6x23 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | TM4 | S | 227 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM4 | S | 227 | 4x40 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | S | 227 | 4x40 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL3 | P | 310 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM3 | T | 214 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | I | 218 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Polar | TM3 | A | 213 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 213 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 213 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Polar | H8 | E | 385 | 8x48 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | F | 387 | 8x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | T | 386 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | T | 386 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Polar | TM6 | R | 319 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | R | 319 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 319 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Polar | TM6 | Q | 313 | 6x23 | G.h4s6 | R | 342 | G.h4s6.11 |
Van-der-waals | TM6 | Q | 313 | 6x23 | G.h4s6 | R | 342 | G.h4s6.11 |
Hydrophobic | TM6 | I | 316 | 6x26 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | H8 | C | 384 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | C | 384 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | R | 303 | 5x64 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM3 | T | 214 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | T | 214 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM3 | R | 210 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 210 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 210 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM2 | D | 148 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | D | 148 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | P | 217 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Polar | TM6 | R | 319 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 319 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL3 | A | 309 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | ICL3 | A | 309 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | A | 309 | - | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | V | 323 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | V | 323 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Polar | TM2 | N | 145 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | N | 145 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | N | 145 | 2x37 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM6 | T | 326 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 326 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL3 | V | 308 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | V | 308 | - | G.H5 | D | 368 | G.H5.13 |
Polar | ICL2 | R | 224 | 34x57 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 224 | 34x57 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM2 | P | 147 | 2x39 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | I | 218 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | H8 | R | 390 | 8x53 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | A | 213 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 213 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | TM2 | N | 144 | 2x36 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM2 | P | 147 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Ionic | TM5 | R | 303 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 303 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 303 | 5x64 | G.H5 | D | 368 | G.H5.13 |
Polar | H8 | E | 385 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | H8 | E | 385 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | H8 | E | 385 | 8x48 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | Q | 313 | 6x23 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ICL2 | I | 218 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | I | 218 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | ICL2 | K | 222 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | K | 222 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM6 | V | 323 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | T | 214 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | T | 214 | 3x54 | G.H5 | L | 371 | G.H5.16 |