Gi3 - MCH1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 A 213 3x53 G.H5 C 351 G.H5.23
Polar ICL2 R 224 34x57 G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 224 34x57 G.H5 N 347 G.H5.19
Aromatic TM6 R 322 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 R 322 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM5 M 304 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 M 304 5x65 G.H5 L 348 G.H5.20
Hydrophobic ICL2 P 217 34x50 G.H5 T 340 G.H5.12
Polar ICL2 R 224 34x57 G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 224 34x57 G.H5 C 351 G.H5.23
Hydrophobic TM5 R 303 5x64 G.H5 I 344 G.H5.16
Hydrophobic ICL3 A 311 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 A 311 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 I 330 6x40 G.H5 L 353 G.H5.25
Hydrophobic ICL3 A 309 - G.S6 Y 320 G.S6.02
Van-der-waals ICL3 A 309 - G.S6 Y 320 G.S6.02
Ionic TM6 R 319 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 319 6x29 G.h4s6 E 318 G.h4s6.12
Polar TM3 R 210 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 210 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 210 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 217 34x50 G.H5 I 343 G.H5.15
Hydrophobic ICL3 A 309 - G.H5 A 338 G.H5.10
Hydrophobic ICL3 P 310 - G.S6 Y 320 G.S6.02
Hydrophobic ICL2 I 218 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 I 218 34x51 G.S3 L 194 G.S3.01
Hydrophobic TM6 V 323 6x33 G.H5 L 348 G.H5.20
Hydrophobic TM6 T 326 6x36 G.H5 L 353 G.H5.25
Polar TM3 A 213 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 213 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 213 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 T 214 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 M 304 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL3 A 309 - G.H5 D 341 G.H5.13
Polar C-term E 418 - G.H3 S 252 G.H3.11
Van-der-waals C-term E 418 - G.H3 S 252 G.H3.11
Hydrophobic ICL3 A 311 - G.S6 Y 320 G.S6.02
Ionic C-term E 415 - G.H2 K 209 G.H2.05
Polar C-term E 415 - G.H2 K 209 G.H2.05
Hydrophobic C-term E 415 - G.H2 K 209 G.H2.05
Van-der-waals C-term E 415 - G.H2 K 209 G.H2.05
Hydrophobic ICL3 P 310 - G.S6 H 322 G.S6.04
Van-der-waals ICL3 P 310 - G.S6 H 322 G.S6.04
Hydrophobic TM2 P 147 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 P 147 2x39 G.H5 C 351 G.H5.23
Hydrophobic ICL2 I 218 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 I 218 34x51 G.H5 F 336 G.H5.08
Polar C-term T 411 - G.H3 K 257 G.H3.16
Hydrophobic C-term T 411 - G.H3 K 257 G.H3.16
Van-der-waals C-term T 411 - G.H3 K 257 G.H3.16
Ionic C-term E 414 - G.h4s6 R 312 G.h4s6.03
Polar C-term E 414 - G.h4s6 R 312 G.h4s6.03
Van-der-waals C-term E 414 - G.h4s6 R 312 G.h4s6.03
Ionic TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Polar TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 R 314 6x24 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 R 319 6x29 G.H5 Y 354 G.H5.26
Hydrophobic TM3 T 214 3x54 G.H5 L 348 G.H5.20
Hydrophobic H8 T 386 8x49 G.H5 K 349 G.H5.21
Van-der-waals H8 T 386 8x49 G.H5 K 349 G.H5.21
Polar H8 T 386 8x49 G.H5 Y 354 G.H5.26
Van-der-waals H8 T 386 8x49 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 P 217 34x50 G.H5 I 344 G.H5.16
Polar H8 C 384 8x47 G.H5 Y 354 G.H5.26
Hydrophobic H8 C 384 8x47 G.H5 Y 354 G.H5.26
Van-der-waals H8 C 384 8x47 G.H5 Y 354 G.H5.26
Ionic TM6 R 319 6x29 G.H5 D 341 G.H5.13
Polar TM6 R 319 6x29 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 319 6x29 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 319 6x29 G.H5 D 341 G.H5.13
Ionic TM4 K 225 4x38 G.HN E 28 G.HN.52
Polar TM4 K 225 4x38 G.HN E 28 G.HN.52
Van-der-waals TM4 K 225 4x38 G.HN E 28 G.HN.52
Hydrophobic TM5 Y 297 5x58 G.H5 L 353 G.H5.25
Polar H8 E 385 8x48 G.H5 Y 354 G.H5.26
Hydrophobic H8 E 385 8x48 G.H5 Y 354 G.H5.26
Van-der-waals H8 E 385 8x48 G.H5 Y 354 G.H5.26
Polar H8 C 384 8x47 G.H5 G 352 G.H5.24
Hydrophobic H8 C 384 8x47 G.H5 G 352 G.H5.24
Van-der-waals H8 C 384 8x47 G.H5 G 352 G.H5.24
Ionic C-term E 415 - G.H3 K 257 G.H3.16
Ionic ICL2 K 222 34x55 G.s2s3 D 193 G.s2s3.02
Polar ICL2 K 222 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL2 K 222 34x55 G.s2s3 D 193 G.s2s3.02
Van-der-waals ICL2 K 222 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic ICL3 A 309 - G.H5 D 337 G.H5.09
Hydrophobic TM3 R 210 3x50 G.H5 L 353 G.H5.25
Hydrophobic TM2 P 147 2x39 G.H5 E 350 G.H5.22
Polar ICL3 P 310 - G.S6 T 321 G.S6.03
Hydrophobic ICL3 P 310 - G.S6 T 321 G.S6.03
Van-der-waals ICL3 P 310 - G.S6 T 321 G.S6.03
Polar TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 S 315 6x25 G.h4s6 E 318 G.h4s6.12
Polar TM5 S 307 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 307 5x68 G.H5 D 341 G.H5.13
Polar C-term N 408 - G.H3 K 257 G.H3.16
Van-der-waals C-term N 408 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 I 218 34x51 G.s2s3 D 193 G.s2s3.02
Polar TM3 R 210 3x50 G.H5 G 352 G.H5.24