GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 84.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | H8 | R | 286 | 8x53 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | H8 | R | 286 | 8x53 | G.h4s6 | D | 316 | G.h4s6.10 |
Van-der-waals | H8 | R | 286 | 8x53 | G.h4s6 | D | 316 | G.h4s6.10 |
Polar | TM2 | N | 59 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | N | 59 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | N | 59 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | S | 126 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | S | 126 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | S | 126 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | H8 | V | 295 | 8x62 | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | H8 | V | 295 | 8x62 | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM5 | W | 204 | 5x62 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | W | 204 | 5x62 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM2 | F | 61 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 61 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | L | 296 | - | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | C-term | L | 296 | - | G.H3 | Y | 258 | G.H3.17 |
Polar | ICL3 | R | 213 | - | G.H4 | L | 308 | G.H4.16 |
Polar | ICL2 | C | 135 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | C | 135 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | C | 135 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Ionic | C-term | E | 303 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | E | 303 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | E | 303 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | E | 303 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | M | 319 | - | G.h1ha | K | 58 | G.h1ha.01 |
Van-der-waals | C-term | M | 319 | - | G.h1ha | K | 58 | G.h1ha.01 |
Polar | H8 | S | 291 | 8x58 | G.H3 | K | 257 | G.H3.16 |
Polar | TM6 | L | 219 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | L | 219 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | L | 300 | - | G.H2 | I | 212 | G.H2.08 |
Polar | TM3 | S | 126 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | S | 126 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 126 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | P | 130 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM6 | L | 219 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | L | 219 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 296 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | TM3 | R | 123 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 123 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 123 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | H | 136 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | I | 131 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL3 | R | 213 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 213 | - | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | V | 205 | 5x63 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL3 | R | 213 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 213 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 127 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | H | 136 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | ICL2 | H | 136 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | H | 136 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | H | 136 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Aromatic | ICL3 | W | 212 | - | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL3 | W | 212 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | W | 212 | - | G.H5 | K | 345 | G.H5.17 |
Polar | H8 | L | 292 | 8x59 | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | H8 | L | 292 | 8x59 | G.H3 | Y | 258 | G.H3.17 |
Van-der-waals | H8 | L | 292 | 8x59 | G.H3 | Y | 258 | G.H3.17 |
Polar | H8 | G | 293 | 8x60 | G.H3 | Y | 258 | G.H3.17 |
Hydrophobic | ICL2 | C | 135 | 34x55 | G.S3 | L | 194 | G.S3.01 |
Ionic | ICL2 | K | 134 | 34x54 | G.H5 | E | 346 | G.H5.18 |
Polar | ICL2 | K | 134 | 34x54 | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | ICL2 | K | 134 | 34x54 | G.H5 | E | 346 | G.H5.18 |
Hydrophobic | ICL2 | F | 133 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | M | 319 | - | G.H1 | K | 54 | G.H1.09 |
Van-der-waals | C-term | M | 319 | - | G.H1 | K | 54 | G.H1.09 |
Hydrophobic | ICL3 | W | 212 | - | G.H5 | F | 354 | G.H5.26 |
Polar | ICL3 | W | 212 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | W | 212 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | W | 212 | - | G.H5 | D | 341 | G.H5.13 |
Ionic | ICL3 | R | 213 | - | G.H4 | D | 309 | G.H4.17 |
Polar | ICL3 | R | 213 | - | G.H4 | D | 309 | G.H4.17 |
Hydrophobic | ICL2 | K | 134 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Polar | H8 | G | 280 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | G | 280 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | G | 280 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL3 | W | 212 | - | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | R | 218 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 218 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | V | 222 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 222 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | I | 131 | 34x51 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL3 | W | 212 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | L | 201 | 5x59 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | F | 61 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | F | 61 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | H8 | R | 283 | 8x50 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | R | 283 | 8x50 | G.H5 | F | 354 | G.H5.26 |
Polar | H8 | L | 292 | 8x59 | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | H8 | L | 292 | 8x59 | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | H8 | L | 292 | 8x59 | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | L | 296 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | L | 300 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | ICL3 | W | 212 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | W | 212 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Ionic | ICL3 | R | 214 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Polar | ICL3 | R | 214 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | ICL3 | R | 214 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | ICL3 | R | 214 | - | G.h4s6 | E | 315 | G.h4s6.09 |
Hydrophobic | TM3 | V | 127 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | C | 135 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | C | 135 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | C | 135 | 34x55 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | P | 130 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | P | 130 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | L | 300 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | L | 296 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | L | 296 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM5 | L | 201 | 5x59 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | P | 216 | 6x30 | G.H5 | F | 354 | G.H5.26 |