GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 78.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.3
PAE mean: 21.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM7 | F | 250 | 7x30 | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | TM7 | F | 250 | 7x30 | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | ECL3 | V | 244 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ECL3 | V | 244 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ECL3 | V | 244 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | N-term | T | 21 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | N-term | T | 21 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | N-term | T | 21 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | S | 170 | 5x33 | G.H3 | N | 278 | G.H3.14 |
Polar | TM6 | L | 240 | 6x59 | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | TM6 | L | 240 | 6x59 | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | N-term | C | 23 | - | G.H5 | Y | 391 | G.H5.23 |
Polar | TM7 | C | 251 | 7x31 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ECL2 | F | 165 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | ECL2 | F | 165 | - | G.H2 | R | 231 | G.H2.04 |
Ionic | TM4 | E | 157 | 4x60 | G.H3 | R | 280 | G.H3.16 |
Polar | TM4 | E | 157 | 4x60 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM4 | E | 157 | 4x60 | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | TM4 | E | 157 | 4x60 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ECL2 | F | 165 | - | G.H3 | L | 272 | G.H3.08 |
Hydrophobic | TM6 | H | 243 | 6x62 | G.h4s6 | R | 356 | G.h4s6.12 |
Ionic | ECL3 | E | 247 | - | G.H5 | R | 389 | G.H5.21 |
Polar | ECL3 | E | 247 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ECL3 | E | 247 | - | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | ECL3 | E | 247 | - | G.H5 | R | 389 | G.H5.21 |
Polar | ECL1 | T | 93 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | ECL1 | T | 93 | - | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | ECL1 | T | 93 | - | G.H2 | Q | 236 | G.H2.09 |
Aromatic | TM6 | W | 241 | 6x60 | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | TM6 | W | 241 | 6x60 | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | TM6 | W | 241 | 6x60 | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | TM3 | K | 96 | 3x26 | G.H2 | I | 235 | G.H2.08 |
Hydrophobic | TM3 | K | 96 | 3x26 | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | TM3 | K | 96 | 3x26 | G.H2 | I | 235 | G.H2.08 |
Polar | N-term | Y | 24 | - | G.H5 | Y | 391 | G.H5.23 |
Aromatic | N-term | Y | 24 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | N-term | Y | 24 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | N-term | Y | 24 | - | G.H5 | Y | 391 | G.H5.23 |
Ionic | TM5 | D | 177 | 5x40 | G.H3 | R | 280 | G.H3.16 |
Polar | TM5 | D | 177 | 5x40 | G.H3 | R | 280 | G.H3.16 |
Ionic | TM5 | D | 169 | 5x32 | G.H3 | K | 274 | G.H3.10 |
Polar | TM5 | D | 169 | 5x32 | G.H3 | K | 274 | G.H3.10 |
Polar | ECL3 | R | 246 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ECL3 | R | 246 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | ECL3 | R | 246 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | TM4 | C | 161 | 4x64 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM4 | C | 161 | 4x64 | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | TM4 | C | 161 | 4x64 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ECL2 | L | 164 | - | G.H3 | I | 276 | G.H3.12 |
Hydrophobic | TM6 | F | 236 | 6x55 | G.H3 | W | 281 | G.H3.17 |
Ionic | TM6 | H | 243 | 6x62 | G.h4s6 | D | 354 | G.h4s6.10 |
Polar | TM6 | H | 243 | 6x62 | G.h4s6 | D | 354 | G.h4s6.10 |
Hydrophobic | TM6 | H | 243 | 6x62 | G.h4s6 | D | 354 | G.h4s6.10 |
Van-der-waals | TM6 | H | 243 | 6x62 | G.h4s6 | D | 354 | G.h4s6.10 |
Polar | N-term | T | 21 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | N-term | T | 21 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | C | 173 | 5x36 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | N-term | E | 19 | - | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | N-term | E | 19 | - | G.H5 | L | 393 | G.H5.25 |
Polar | N-term | C | 23 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | N-term | C | 23 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | N-term | C | 23 | - | G.H5 | E | 392 | G.H5.24 |
Polar | ECL3 | R | 246 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Aromatic | ECL3 | R | 246 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Hydrophobic | ECL3 | R | 246 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Van-der-waals | ECL3 | R | 246 | - | G.h4s6 | H | 357 | G.h4s6.13 |
Hydrophobic | TM3 | K | 96 | 3x26 | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | TM3 | K | 96 | 3x26 | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | ECL2 | L | 164 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | ECL2 | L | 164 | - | G.H2 | I | 235 | G.H2.08 |
Polar | ECL1 | H | 92 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ECL1 | H | 92 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | ECL1 | H | 92 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Ionic | N-term | E | 20 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | N-term | E | 20 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | N-term | E | 20 | - | G.H5 | L | 393 | G.H5.25 |
Aromatic | TM3 | Y | 99 | 3x29 | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | TM3 | Y | 99 | 3x29 | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | TM3 | Y | 99 | 3x29 | G.H3 | W | 281 | G.H3.17 |
Hydrophobic | ECL2 | G | 162 | - | G.H2 | I | 235 | G.H2.08 |
Van-der-waals | ECL2 | G | 162 | - | G.H2 | I | 235 | G.H2.08 |
Ionic | TM7 | H | 252 | 7x32 | G.H5 | E | 392 | G.H5.24 |
Polar | TM7 | H | 252 | 7x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | H | 252 | 7x32 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | H | 252 | 7x32 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ECL2 | F | 165 | - | G.H2 | R | 232 | G.H2.05 |
Van-der-waals | ECL2 | F | 165 | - | G.H2 | R | 232 | G.H2.05 |
Polar | N-term | Y | 24 | - | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | N-term | Y | 24 | - | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | N-term | Y | 24 | - | G.hns1 | R | 38 | G.hns1.02 |
Polar | N-term | T | 21 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | N-term | T | 21 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | N-term | T | 21 | - | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | L | 240 | 6x59 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | L | 240 | 6x59 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM6 | L | 240 | 6x59 | G.h4s6 | R | 356 | G.h4s6.12 |
Ionic | ECL3 | D | 245 | - | G.H5 | R | 389 | G.H5.21 |
Polar | TM6 | I | 242 | 6x61 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | I | 242 | 6x61 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM6 | I | 242 | 6x61 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM2 | F | 87 | 2x65 | G.HN | K | 34 | G.HN.51 |
Van-der-waals | TM2 | F | 87 | 2x65 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ECL2 | L | 164 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Van-der-waals | ECL2 | L | 164 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Polar | TM3 | Y | 99 | 3x29 | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | TM3 | Y | 99 | 3x29 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | TM6 | F | 236 | 6x55 | G.H3 | R | 280 | G.H3.16 |
Van-der-waals | TM6 | F | 236 | 6x55 | G.H3 | R | 280 | G.H3.16 |
Hydrophobic | ECL3 | R | 246 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | ECL3 | R | 246 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Polar | ECL1 | S | 89 | - | G.hns1 | Y | 37 | G.hns1.01 |
Hydrophobic | ECL1 | S | 89 | - | G.hns1 | Y | 37 | G.hns1.01 |
Van-der-waals | ECL1 | S | 89 | - | G.hns1 | Y | 37 | G.hns1.01 |
Hydrophobic | N-term | L | 22 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | N-term | L | 22 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM1 | L | 28 | 1x33 | G.hns1 | R | 38 | G.hns1.02 |
Polar | ECL3 | R | 246 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | ECL3 | R | 246 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Van-der-waals | ECL3 | R | 246 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Hydrophobic | ECL2 | L | 164 | - | G.H2 | W | 234 | G.H2.07 |
Polar | TM6 | F | 239 | 6x58 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM6 | F | 239 | 6x58 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ECL2 | L | 164 | - | G.H3 | N | 279 | G.H3.15 |
Van-der-waals | ECL2 | L | 164 | - | G.H3 | N | 279 | G.H3.15 |
Polar | ECL1 | H | 92 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Hydrophobic | ECL1 | H | 92 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Van-der-waals | ECL1 | H | 92 | - | G.h2s4 | F | 238 | G.h2s4.01 |
Polar | TM7 | C | 251 | 7x31 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | C | 251 | 7x31 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM7 | C | 251 | 7x31 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM7 | L | 249 | 7x29 | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | TM7 | L | 249 | 7x29 | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | TM6 | H | 243 | 6x62 | G.h4s6 | G | 353 | G.h4s6.09 |
Hydrophobic | TM1 | L | 28 | 1x33 | G.HN | K | 34 | G.HN.51 |
Van-der-waals | TM1 | L | 28 | 1x33 | G.HN | K | 34 | G.HN.51 |
Aromatic | ECL2 | F | 165 | - | G.H2 | W | 234 | G.H2.07 |
Hydrophobic | ECL2 | F | 165 | - | G.H2 | W | 234 | G.H2.07 |
Van-der-waals | ECL2 | F | 165 | - | G.H2 | W | 234 | G.H2.07 |
Polar | TM6 | H | 243 | 6x62 | G.h4s6 | S | 352 | G.h4s6.08 |
Hydrophobic | TM6 | H | 243 | 6x62 | G.h4s6 | S | 352 | G.h4s6.08 |
Van-der-waals | TM6 | H | 243 | 6x62 | G.h4s6 | S | 352 | G.h4s6.08 |
Polar | ECL1 | H | 92 | - | G.H2 | Q | 236 | G.H2.09 |
Hydrophobic | ECL1 | H | 92 | - | G.H2 | Q | 236 | G.H2.09 |
Van-der-waals | ECL1 | H | 92 | - | G.H2 | Q | 236 | G.H2.09 |