G12 -
MC1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM5 | I | 221 | 5x72 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM5 | L | 224 | 5x75 | G.S6 | F | 347 | G.S6.02 |
Polar | TM7 | H | 301 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM7 | H | 301 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM7 | H | 301 | 7x56 | G.H5 | L | 380 | G.H5.25 |
Polar | TM5 | H | 225 | 5x76 | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | TM3 | R | 142 | 3x50 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM6 | F | 235 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | F | 235 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | C | 315 | - | G.HN | C | 11 | G.HN.11 |
Hydrophobic | C-term | C | 315 | - | G.HN | C | 11 | G.HN.11 |
Van-der-waals | C-term | C | 315 | - | G.HN | C | 11 | G.HN.11 |
Polar | ICL1 | N | 68 | 12x49 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM6 | I | 245 | 6x39 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | M | 379 | G.H5.24 |
Polar | ICL1 | N | 68 | 12x49 | G.HN | R | 51 | G.HN.51 |
Van-der-waals | ICL1 | N | 68 | 12x49 | G.HN | R | 51 | G.HN.51 |
Polar | TM6 | T | 242 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 242 | 6x36 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Polar | TM5 | H | 225 | 5x76 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM5 | H | 225 | 5x76 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM5 | H | 225 | 5x76 | G.h4s6 | P | 345 | G.h4s6.20 |
Polar | TM7 | H | 301 | 7x56 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM7 | H | 301 | 7x56 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM7 | H | 301 | 7x56 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | R | 151 | 34x52 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | I | 146 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | TM7 | H | 301 | 7x56 | G.H5 | K | 376 | G.H5.21 |
Polar | TM5 | H | 217 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | H | 217 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Ionic | ICL1 | R | 67 | 12x48 | G.HN | D | 44 | G.HN.44 |
Polar | ICL1 | R | 67 | 12x48 | G.HN | D | 44 | G.HN.44 |
Van-der-waals | ICL1 | R | 67 | 12x48 | G.HN | D | 44 | G.HN.44 |
Van-der-waals | TM6 | F | 235 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Ionic | TM5 | H | 217 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | H | 217 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | H | 217 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | F | 235 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Polar | ICL2 | H | 153 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | H | 217 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM6 | T | 242 | 6x36 | G.H5 | I | 378 | G.H5.23 |
Polar | TM5 | H | 225 | 5x76 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM5 | H | 225 | 5x76 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM3 | I | 146 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | TM5 | R | 213 | 5x64 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM6 | G | 239 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | G | 239 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Ionic | H8 | E | 304 | 8x49 | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM3 | S | 145 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | S | 145 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | S | 145 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | A | 149 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL3 | Q | 228 | - | G.H4 | D | 336 | G.H4.16 |
Hydrophobic | ICL3 | Q | 228 | - | G.H4 | D | 336 | G.H4.16 |
Van-der-waals | ICL3 | Q | 228 | - | G.H4 | D | 336 | G.H4.16 |
Polar | TM6 | T | 242 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | T | 242 | 6x36 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM5 | A | 214 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | A | 214 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | M | 210 | 5x61 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM5 | H | 217 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM4 | L | 158 | 4x39 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | L | 158 | 4x39 | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | H | 153 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | H | 153 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | H | 153 | 34x54 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM6 | K | 238 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 238 | 6x32 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | ICL2 | L | 150 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 150 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM5 | I | 221 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | I | 221 | 5x72 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM4 | T | 157 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | TM4 | T | 157 | 4x38 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM7 | H | 301 | 7x56 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM7 | H | 301 | 7x56 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM7 | H | 301 | 7x56 | G.H5 | D | 377 | G.H5.22 |
Polar | ICL1 | H | 70 | 12x51 | G.HN | R | 52 | G.HN.52 |