G12 - MC1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 F 235 6x29 G.H5 Q 381 G.H5.26
Ionic ICL1 R 67 12x48 G.HN D 44 G.HN.44
Polar ICL1 R 67 12x48 G.HN D 44 G.HN.44
Van-der-waals ICL1 R 67 12x48 G.HN D 44 G.HN.44
Polar C-term C 315 - G.HN C 11 G.HN.11
Hydrophobic C-term C 315 - G.HN C 11 G.HN.11
Van-der-waals C-term C 315 - G.HN C 11 G.HN.11
Polar ICL1 N 68 12x49 G.HN R 51 G.HN.51
Van-der-waals ICL1 N 68 12x49 G.HN R 51 G.HN.51
Hydrophobic ICL2 L 150 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 R 213 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 224 5x75 G.S6 F 347 G.S6.02
Hydrophobic TM5 A 214 5x65 G.H5 L 375 G.H5.20
Van-der-waals TM5 A 214 5x65 G.H5 L 375 G.H5.20
Polar TM7 H 301 7x56 G.H5 Q 381 G.H5.26
Hydrophobic TM7 H 301 7x56 G.H5 Q 381 G.H5.26
Van-der-waals TM7 H 301 7x56 G.H5 Q 381 G.H5.26
Ionic TM5 H 217 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 217 5x68 G.H5 D 368 G.H5.13
Hydrophobic TM5 H 217 5x68 G.H5 D 368 G.H5.13
Van-der-waals TM5 H 217 5x68 G.H5 D 368 G.H5.13
Polar TM5 H 225 5x76 G.h4s6 K 344 G.h4s6.19
Hydrophobic TM5 H 225 5x76 G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 L 150 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 151 34x52 G.S3 I 221 G.S3.01
Polar TM3 S 145 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 145 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 145 3x53 G.H5 N 374 G.H5.19
Polar ICL2 H 153 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 153 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 H 153 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 146 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 I 146 3x54 G.H5 I 378 G.H5.23
Polar TM6 T 242 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM6 T 242 6x36 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 146 3x54 G.H5 L 375 G.H5.20
Polar ICL1 N 68 12x49 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 K 238 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 238 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM4 T 157 4x38 G.hns1 R 56 G.hns1.03
Van-der-waals TM4 T 157 4x38 G.hns1 R 56 G.hns1.03
Polar ICL3 Q 228 - G.H4 D 336 G.H4.16
Hydrophobic ICL3 Q 228 - G.H4 D 336 G.H4.16
Van-der-waals ICL3 Q 228 - G.H4 D 336 G.H4.16
Polar TM5 H 225 5x76 G.h4s6 R 342 G.h4s6.11
Polar TM7 H 301 7x56 G.H5 D 377 G.H5.22
Hydrophobic TM7 H 301 7x56 G.H5 D 377 G.H5.22
Van-der-waals TM7 H 301 7x56 G.H5 D 377 G.H5.22
Hydrophobic ICL2 L 150 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 150 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 L 150 34x51 G.H5 V 366 G.H5.11
Polar ICL2 H 153 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 H 153 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 H 153 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 H 217 5x68 G.H5 L 375 G.H5.20
Van-der-waals TM5 H 217 5x68 G.H5 L 375 G.H5.20
Hydrophobic TM6 T 242 6x36 G.H5 I 378 G.H5.23
Van-der-waals TM6 T 242 6x36 G.H5 I 378 G.H5.23
Hydrophobic TM6 F 235 6x29 G.H5 M 379 G.H5.24
Van-der-waals TM6 F 235 6x29 G.H5 M 379 G.H5.24
Polar TM3 R 142 3x50 G.H5 D 377 G.H5.22
Polar TM7 H 301 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM7 H 301 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 H 301 7x56 G.H5 L 380 G.H5.25
Hydrophobic TM4 L 158 4x39 G.HN R 52 G.HN.52
Van-der-waals TM4 L 158 4x39 G.HN R 52 G.HN.52
Polar TM5 H 225 5x76 G.h4s6 P 345 G.h4s6.20
Hydrophobic TM5 H 225 5x76 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM5 H 225 5x76 G.h4s6 P 345 G.h4s6.20
Van-der-waals TM6 F 235 6x29 G.H5 Q 372 G.H5.17
Hydrophobic TM5 M 210 5x61 G.H5 I 378 G.H5.23
Hydrophobic TM5 H 217 5x68 G.H5 L 371 G.H5.16
Hydrophobic TM5 I 221 5x72 G.h4s6 P 345 G.h4s6.20
Polar TM5 H 217 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM5 H 217 5x68 G.H5 Q 372 G.H5.17
Van-der-waals TM5 H 217 5x68 G.H5 Q 372 G.H5.17
Hydrophobic TM6 K 238 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 238 6x32 G.H5 M 379 G.H5.24
Hydrophobic TM5 I 221 5x72 G.H5 Q 372 G.H5.17
Van-der-waals TM5 I 221 5x72 G.H5 Q 372 G.H5.17
Ionic H8 E 304 8x49 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 A 149 34x50 G.H5 I 370 G.H5.15
Polar ICL1 H 70 12x51 G.HN R 52 G.HN.52
Hydrophobic ICL2 L 150 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 150 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM6 I 245 6x39 G.H5 L 380 G.H5.25
Polar TM6 T 242 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM6 T 242 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 242 6x36 G.H5 M 379 G.H5.24
Polar TM7 H 301 7x56 G.H5 K 376 G.H5.21
Hydrophobic ICL2 L 150 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 150 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM6 G 239 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 G 239 6x33 G.H5 M 379 G.H5.24
Hydrophobic TM3 I 146 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 146 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM3 R 142 3x50 G.H5 I 378 G.H5.23