G12 - motilin receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 77.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.0


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM6 R 289 6x26 G.H5 Q 372 G.H5.17
Hydrophobic TM4 T 151 4x38 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 140 3x54 G.H5 L 375 G.H5.20
Polar H8 S 359 8x47 G.H5 M 379 G.H5.24
Polar ICL2 R 147 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 147 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 147 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 A 285 - G.h4s6 K 344 G.h4s6.19
Van-der-waals ICL3 A 285 - G.h4s6 K 344 G.h4s6.19
Ionic TM6 R 289 6x26 G.H5 D 368 G.H5.13
Polar TM6 R 289 6x26 G.H5 D 368 G.H5.13
Hydrophobic TM6 R 289 6x26 G.H5 D 368 G.H5.13
Van-der-waals TM6 R 289 6x26 G.H5 D 368 G.H5.13
Hydrophobic H8 K 360 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 K 360 8x48 G.H5 Q 381 G.H5.26
Ionic TM5 E 273 5x64 G.H5 K 367 G.H5.12
Polar TM5 E 273 5x64 G.H5 K 367 G.H5.12
Van-der-waals TM5 E 273 5x64 G.H5 K 367 G.H5.12
Hydrophobic ICL2 L 144 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM5 P 280 5x71 G.H5 H 364 G.H5.09
Polar TM3 A 139 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 139 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 139 3x53 G.H5 N 374 G.H5.19
Hydrophobic ICL2 L 144 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 L 144 34x51 G.H5 F 363 G.H5.08
Polar TM6 H 293 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 H 293 6x30 G.H5 Q 372 G.H5.17
Polar TM6 Q 295 6x32 G.H5 Q 381 G.H5.26
Van-der-waals TM6 Q 295 6x32 G.H5 Q 381 G.H5.26
Hydrophobic TM6 T 296 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 T 296 6x33 G.H5 M 379 G.H5.24
Polar H8 K 361 8x49 G.H5 L 380 G.H5.25
Polar ICL2 R 147 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 147 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 147 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 L 144 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 L 144 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM5 L 274 5x65 G.H5 L 375 G.H5.20
Polar H8 S 359 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 359 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 359 8x47 G.H5 L 380 G.H5.25
Hydrophobic ICL3 A 285 - G.h4s6 P 345 G.h4s6.20
Van-der-waals ICL3 A 285 - G.h4s6 P 345 G.h4s6.20
Polar H8 K 360 8x48 G.H5 L 380 G.H5.25
Van-der-waals H8 K 360 8x48 G.H5 L 380 G.H5.25
Hydrophobic TM6 Q 295 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 Q 295 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 147 34x54 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 147 34x54 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 140 3x54 G.H5 L 371 G.H5.16
Hydrophobic ICL2 L 144 34x51 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 147 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM6 V 299 6x36 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 299 6x36 G.H5 M 379 G.H5.24
Hydrophobic ICL2 L 144 34x51 G.S1 V 58 G.S1.02
Hydrophobic TM5 L 281 5x72 G.h4s6 P 345 G.h4s6.20
Polar ICL2 V 148 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 V 148 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 148 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic TM2 N 74 2x40 G.H5 L 380 G.H5.25
Van-der-waals TM2 N 74 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 V 148 34x55 G.S3 P 222 G.S3.02
Polar ICL2 R 147 34x54 G.S1 L 57 G.S1.01
Hydrophobic ICL2 R 147 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 R 147 34x54 G.S1 L 57 G.S1.01
Hydrophobic TM3 A 139 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 139 3x53 G.H5 I 378 G.H5.23
Van-der-waals H8 K 361 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM7 Y 355 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 355 7x53 G.H5 L 380 G.H5.25
Hydrophobic TM6 H 293 6x30 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 143 34x50 G.H5 I 370 G.H5.15
Polar TM2 T 73 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM4 R 154 4x41 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 I 140 3x54 G.H5 I 378 G.H5.23
Hydrophobic ICL2 L 144 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 L 144 34x51 G.H5 I 370 G.H5.15
Hydrophobic ICL2 V 148 34x55 G.S3 I 221 G.S3.01
Hydrophobic ICL2 L 144 34x51 G.H5 V 366 G.H5.11
Hydrophobic TM5 L 281 5x72 G.S6 F 347 G.S6.02
Polar TM3 R 136 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 136 3x50 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 143 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 T 296 6x33 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 143 34x50 G.H5 K 367 G.H5.12
Van-der-waals ICL2 P 143 34x50 G.H5 K 367 G.H5.12
Ionic H8 K 361 8x49 G.H5 D 377 G.H5.22
Polar H8 K 361 8x49 G.H5 D 377 G.H5.22
Van-der-waals H8 K 361 8x49 G.H5 D 377 G.H5.22