GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 66.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | V | 215 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL2 | L | 134 | 34x51 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | TM5 | A | 222 | 5x72 | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 126 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 130 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | I | 130 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | S | 457 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | S | 457 | - | G.H2 | R | 210 | G.H2.01 |
Van-der-waals | C-term | S | 457 | - | G.H2 | R | 210 | G.H2.01 |
Hydrophobic | C-term | F | 460 | - | G.H3 | I | 258 | G.H3.12 |
Ionic | C-term | R | 339 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Polar | C-term | R | 339 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Van-der-waals | C-term | R | 339 | - | G.h2s4 | E | 221 | G.h2s4.02 |
Hydrophobic | C-term | L | 370 | - | G.H2 | H | 218 | G.H2.09 |
Hydrophobic | TM5 | A | 222 | 5x72 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM6 | T | 238 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 238 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | I | 130 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | I | 130 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | V | 458 | - | G.H3 | A | 253 | G.H3.07 |
Hydrophobic | TM5 | K | 214 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | K | 214 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM3 | I | 130 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL3 | Q | 224 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | Q | 224 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM5 | P | 221 | 5x71 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM5 | A | 218 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Polar | ICL3 | Q | 224 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | ICL3 | Q | 224 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | Q | 224 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | C-term | V | 458 | - | G.H3 | L | 254 | G.H3.08 |
Polar | C-term | F | 460 | - | G.H3 | Y | 261 | G.H3.15 |
Aromatic | C-term | F | 460 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | F | 460 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | F | 460 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | TM3 | Y | 129 | 3x53 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM3 | Y | 129 | 3x53 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | TM3 | Y | 129 | 3x53 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | C-term | F | 460 | - | G.H2 | W | 216 | G.H2.07 |
Hydrophobic | TM2 | N | 61 | 2x37 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | I | 211 | 5x61 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | I | 130 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 130 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM6 | M | 239 | 6x37 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | L | 370 | - | G.H2 | K | 215 | G.H2.06 |
Hydrophobic | TM6 | N | 235 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | N | 235 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Ionic | TM5 | R | 219 | 5x69 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM5 | R | 219 | 5x69 | G.H5 | D | 346 | G.H5.13 |
Polar | C-term | S | 457 | - | G.H3 | E | 250 | G.H3.04 |
Van-der-waals | C-term | S | 457 | - | G.H3 | E | 250 | G.H3.04 |
Hydrophobic | TM6 | M | 239 | 6x37 | G.H5 | L | 353 | G.H5.20 |
Aromatic | TM3 | Y | 129 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | Y | 129 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | Y | 129 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Polar | H8 | N | 298 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | N | 298 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 298 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | T | 238 | 6x36 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | F | 460 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Van-der-waals | C-term | F | 460 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | TM5 | A | 222 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | TM5 | A | 222 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Polar | ICL2 | Y | 136 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | Y | 136 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | Y | 136 | 34x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | V | 215 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | V | 215 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Polar | TM6 | M | 239 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | M | 239 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | M | 239 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | N | 300 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Polar | H8 | N | 300 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | H8 | N | 300 | 8x49 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | R | 126 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | R | 126 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | A | 222 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | A | 222 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | C-term | M | 363 | - | G.H1 | R | 60 | G.H1.09 |
Van-der-waals | C-term | M | 363 | - | G.H1 | R | 60 | G.H1.09 |
Polar | TM3 | Y | 129 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM3 | Y | 129 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM3 | Y | 129 | 3x53 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | Y | 129 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | Y | 129 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | Y | 129 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | M | 363 | - | G.h1ha | A | 65 | G.h1ha.02 |
Hydrophobic | TM5 | Y | 208 | 5x58 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM5 | Y | 208 | 5x58 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | V | 365 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | V | 365 | - | G.S2 | I | 190 | G.S2.02 |
Polar | H8 | E | 299 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | E | 299 | 8x48 | G.H5 | N | 357 | G.H5.24 |
Polar | TM3 | R | 126 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 126 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 126 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | G | 63 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | V | 458 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | V | 458 | - | G.H3 | T | 257 | G.H3.11 |
Ionic | ICL2 | E | 137 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | E | 137 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | E | 137 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | TM5 | A | 218 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | A | 218 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Polar | H8 | N | 300 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 300 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | N | 125 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL3 | Q | 224 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | Q | 224 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | F | 460 | - | G.H3 | T | 257 | G.H3.11 |