Gq - GPR50 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gq/11

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 66.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 13.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 L 134 34x51 G.S1 L 40 G.S1.02
Van-der-waals ICL2 L 134 34x51 G.S1 L 40 G.S1.02
Hydrophobic TM5 V 215 5x65 G.H5 L 353 G.H5.20
Hydrophobic ICL2 L 134 34x51 G.H5 I 348 G.H5.15
Hydrophobic C-term F 460 - G.H3 L 254 G.H3.08
Hydrophobic TM6 E 232 6x30 G.H5 L 358 G.H5.25
Van-der-waals TM6 E 232 6x30 G.H5 L 358 G.H5.25
Hydrophobic TM3 I 130 3x54 G.H5 L 353 G.H5.20
Van-der-waals TM3 I 130 3x54 G.H5 L 353 G.H5.20
Ionic C-term R 333 - G.HN E 26 G.HN.44
Polar C-term R 333 - G.HN E 26 G.HN.44
Van-der-waals C-term R 333 - G.HN E 26 G.HN.44
Hydrophobic C-term F 460 - G.H3 I 258 G.H3.12
Hydrophobic ICL2 L 134 34x51 G.S3 V 199 G.S3.01
Hydrophobic ICL2 S 133 34x50 G.H5 I 348 G.H5.15
Van-der-waals ICL2 S 133 34x50 G.H5 I 348 G.H5.15
Hydrophobic TM5 A 218 5x68 G.H5 L 353 G.H5.20
Van-der-waals TM5 A 218 5x68 G.H5 L 353 G.H5.20
Polar C-term R 337 - G.HN A 18 G.HN.36
Hydrophobic C-term L 370 - G.H2 H 218 G.H2.09
Van-der-waals C-term L 370 - G.H2 H 218 G.H2.09
Hydrophobic ICL2 Q 135 34x52 G.s2s3 S 198 G.s2s3.02
Polar C-term F 453 - G.H3 R 256 G.H3.10
Hydrophobic TM3 I 130 3x54 G.H5 L 358 G.H5.25
Van-der-waals TM3 I 130 3x54 G.H5 L 358 G.H5.25
Hydrophobic TM6 E 232 6x30 G.H5 V 359 G.H5.26
Polar TM6 N 235 6x33 G.H5 N 357 G.H5.24
Hydrophobic TM6 N 235 6x33 G.H5 N 357 G.H5.24
Van-der-waals TM6 N 235 6x33 G.H5 N 357 G.H5.24
Van-der-waals TM4 R 143 4x40 G.HN R 34 G.HN.52
Hydrophobic TM5 K 214 5x64 G.H5 L 349 G.H5.16
Hydrophobic C-term F 460 - G.H2 W 216 G.H2.07
Hydrophobic C-term R 337 - G.HN I 21 G.HN.39
Van-der-waals C-term R 337 - G.HN I 21 G.HN.39
Hydrophobic TM6 M 239 6x37 G.H5 Y 356 G.H5.23
Van-der-waals TM6 M 239 6x37 G.H5 Y 356 G.H5.23
Hydrophobic TM3 I 130 3x54 G.H5 L 349 G.H5.16
Van-der-waals TM3 I 130 3x54 G.H5 L 349 G.H5.16
Hydrophobic ICL2 S 133 34x50 G.H5 N 352 G.H5.19
Van-der-waals ICL2 S 133 34x50 G.H5 N 352 G.H5.19
Hydrophobic C-term L 370 - G.H2 K 215 G.H2.06
Van-der-waals C-term L 370 - G.H2 K 215 G.H2.06
Hydrophobic ICL2 L 134 34x51 G.H5 F 341 G.H5.08
Van-der-waals ICL2 L 134 34x51 G.H5 F 341 G.H5.08
Polar TM5 A 218 5x68 G.H5 Q 350 G.H5.17
Hydrophobic TM5 A 218 5x68 G.H5 Q 350 G.H5.17
Van-der-waals TM5 A 218 5x68 G.H5 Q 350 G.H5.17
Hydrophobic C-term V 365 - G.S2 Y 192 G.S2.04
Polar C-term S 457 - G.H3 E 250 G.H3.04
Hydrophobic TM5 I 211 5x61 G.H5 L 358 G.H5.25
Hydrophobic TM3 Y 129 3x53 G.H5 Y 356 G.H5.23
Van-der-waals TM3 Y 129 3x53 G.H5 Y 356 G.H5.23
Polar ICL2 R 138 34x55 G.s2s3 Q 197 G.s2s3.01
Van-der-waals ICL2 R 138 34x55 G.s2s3 Q 197 G.s2s3.01
Aromatic C-term F 446 - G.H4 K 311 G.H4.13
Hydrophobic C-term F 446 - G.H4 K 311 G.H4.13
Van-der-waals C-term F 446 - G.H4 K 311 G.H4.13
Hydrophobic C-term F 460 - G.h2s4 F 220 G.h2s4.01
Hydrophobic TM6 M 239 6x37 G.H5 L 358 G.H5.25
Ionic ICL1 K 57 12x48 G.HN E 26 G.HN.44
Polar ICL1 K 57 12x48 G.HN E 26 G.HN.44
Van-der-waals ICL1 K 57 12x48 G.HN E 26 G.HN.44
Polar TM4 S 141 4x38 G.HN R 34 G.HN.52
Hydrophobic TM4 S 141 4x38 G.HN R 34 G.HN.52
Van-der-waals TM4 S 141 4x38 G.HN R 34 G.HN.52
Hydrophobic ICL2 L 134 34x51 G.H5 K 345 G.H5.12
Polar C-term R 333 - G.HN N 22 G.HN.40
Hydrophobic C-term R 333 - G.HN N 22 G.HN.40
Van-der-waals C-term R 333 - G.HN N 22 G.HN.40
Polar TM3 Y 129 3x53 G.H5 E 355 G.H5.22
Van-der-waals TM3 Y 129 3x53 G.H5 E 355 G.H5.22
Polar TM3 Y 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM3 Y 129 3x53 G.H5 N 352 G.H5.19
Van-der-waals TM3 Y 129 3x53 G.H5 N 352 G.H5.19
Hydrophobic TM6 F 236 6x34 G.H5 L 358 G.H5.25
Van-der-waals TM6 F 236 6x34 G.H5 L 358 G.H5.25
Hydrophobic C-term M 363 - G.H1 R 60 G.H1.09
Van-der-waals C-term M 363 - G.H1 R 60 G.H1.09
Hydrophobic C-term V 365 - G.S2 I 190 G.S2.02
Van-der-waals C-term V 365 - G.S2 I 190 G.S2.02
Hydrophobic C-term V 458 - G.H3 T 257 G.H3.11
Van-der-waals C-term V 458 - G.H3 T 257 G.H3.11
Hydrophobic TM3 R 126 3x50 G.H5 Y 356 G.H5.23
Hydrophobic C-term P 462 - G.H2 I 217 G.H2.08
Van-der-waals C-term P 462 - G.H2 I 217 G.H2.08
Hydrophobic TM5 V 215 5x65 G.H5 L 358 G.H5.25
Van-der-waals TM5 V 215 5x65 G.H5 L 358 G.H5.25
Ionic ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Polar ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Van-der-waals ICL2 E 137 34x54 G.hns1 R 37 G.hns1.02
Hydrophobic TM6 N 235 6x33 G.H5 L 358 G.H5.25
Van-der-waals TM6 N 235 6x33 G.H5 L 358 G.H5.25
Hydrophobic TM5 A 218 5x68 G.H5 L 349 G.H5.16
Polar C-term F 460 - G.H3 Y 261 G.H3.15
Aromatic C-term F 460 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 460 - G.H3 Y 261 G.H3.15
Van-der-waals C-term F 460 - G.H3 Y 261 G.H3.15
Hydrophobic C-term F 460 - G.H3 T 257 G.H3.11
Van-der-waals C-term F 460 - G.H3 T 257 G.H3.11