G13 -
NK2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 15.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | A | 134 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 134 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | M | 245 | 6x30 | G.H5 | L | 367 | G.H5.16 |
Polar | C-term | Y | 386 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Aromatic | ICL2 | F | 139 | - | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | F | 139 | - | G.H5 | F | 359 | G.H5.08 |
Polar | TM5 | H | 232 | 5x73 | G.S6 | H | 344 | G.S6.03 |
Polar | TM5 | H | 232 | 5x73 | G.S6 | H | 345 | G.S6.04 |
Aromatic | TM5 | H | 232 | 5x73 | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | TM5 | H | 232 | 5x73 | G.S6 | H | 345 | G.S6.04 |
Van-der-waals | TM5 | H | 232 | 5x73 | G.S6 | H | 345 | G.S6.04 |
Hydrophobic | ICL2 | F | 139 | - | G.S3 | F | 218 | G.S3.03 |
Hydrophobic | TM6 | F | 248 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | F | 248 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM5 | L | 224 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | F | 139 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | P | 141 | - | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | L | 382 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | L | 382 | - | H.HA | D | 101 | H.HA.24 |
Aromatic | C-term | W | 383 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | W | 383 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | W | 383 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | Y | 386 | - | G.s4h3 | L | 261 | G.s4h3.13 |
Hydrophobic | TM6 | F | 248 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | H8 | R | 313 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Ionic | TM5 | R | 227 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | H8 | F | 314 | 8x50 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | F | 314 | 8x50 | G.H5 | Q | 377 | G.H5.26 |
Polar | TM6 | R | 240 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | ICL2 | P | 138 | - | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | A | 244 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 244 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | C-term | F | 384 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM5 | L | 224 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 224 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM6 | F | 248 | 6x33 | G.H5 | L | 374 | G.H5.23 |
Polar | TM2 | T | 68 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | T | 68 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | T | 68 | 2x39 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | R | 142 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | P | 138 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | L | 382 | - | H.HB | M | 123 | H.HB.10 |
Van-der-waals | C-term | L | 382 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | C-term | Y | 386 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | Y | 386 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | ICL2 | P | 138 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 138 | - | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM5 | H | 232 | 5x73 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | ICL2 | F | 139 | - | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | F | 139 | - | G.S3 | V | 216 | G.S3.01 |
Polar | TM5 | R | 227 | 5x68 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM5 | R | 227 | 5x68 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | TM5 | R | 227 | 5x68 | G.H5 | K | 363 | G.H5.12 |
Polar | TM2 | T | 66 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | T | 66 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | T | 66 | 2x37 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | R | 142 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | R | 142 | - | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | R | 142 | - | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM6 | H | 241 | 6x26 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | N | 69 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | N | 69 | 2x40 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | C-term | W | 383 | - | H.hahb | H | 107 | H.hahb.01 |
Van-der-waals | C-term | W | 383 | - | H.hahb | H | 107 | H.hahb.01 |
Polar | C-term | W | 383 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | W | 383 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | W | 383 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | TM2 | T | 68 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | M | 245 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | M | 245 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | I | 72 | 2x43 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM2 | I | 72 | 2x43 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | H | 312 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | P | 138 | - | G.H5 | L | 367 | G.H5.16 |
Polar | H8 | N | 311 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | N | 311 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | N | 311 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | W | 383 | - | H.HA | E | 104 | H.HA.27 |
Van-der-waals | C-term | W | 383 | - | H.HA | E | 104 | H.HA.27 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | F | 139 | - | G.H5 | I | 366 | G.H5.15 |
Polar | ICL3 | H | 235 | - | G.H4 | R | 331 | G.H4.16 |
Aromatic | ICL3 | H | 235 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | H | 235 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | H | 235 | - | G.H4 | R | 331 | G.H4.16 |
Polar | H8 | N | 311 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 311 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 311 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | C-term | L | 382 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | L | 382 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | L | 382 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | H | 241 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Aromatic | TM6 | H | 241 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | H | 241 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | H | 241 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | P | 141 | - | G.HN | T | 43 | G.HN.52 |
Polar | ICL2 | R | 142 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | R | 142 | - | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | R | 142 | - | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | P | 141 | - | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | P | 141 | - | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | R | 227 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | R | 227 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | F | 139 | - | G.S1 | V | 49 | G.S1.02 |
Polar | H8 | N | 311 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 311 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | N | 311 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Ionic | ICL3 | H | 235 | - | G.H4 | E | 328 | G.H4.13 |