Gi1 -
NK2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | V | 229 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | TM5 | V | 229 | 5x70 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | TM6 | A | 244 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 244 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | P | 230 | 5x71 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | P | 230 | 5x71 | G.H5 | F | 334 | G.H5.06 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | P | 138 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | P | 230 | 5x71 | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | A | 234 | - | G.H4 | E | 308 | G.H4.16 |
Polar | H8 | N | 311 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | N | 311 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | N | 311 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM4 | A | 145 | 4x39 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | A | 145 | 4x39 | G.HN | R | 24 | G.HN.48 |
Polar | ICL2 | R | 142 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | R | 142 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | R | 142 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | P | 230 | 5x71 | G.H5 | A | 338 | G.H5.10 |
Van-der-waals | TM5 | P | 230 | 5x71 | G.H5 | A | 338 | G.H5.10 |
Hydrophobic | TM6 | M | 252 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | M | 252 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | F | 139 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Ionic | H8 | R | 313 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | H8 | R | 313 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | R | 313 | 8x49 | G.H5 | D | 350 | G.H5.22 |
Polar | TM4 | S | 144 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | S | 144 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | S | 144 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | F | 139 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | G | 231 | 5x72 | G.S6 | T | 321 | G.S6.03 |
Ionic | ICL1 | R | 63 | 12x49 | G.h3s5 | D | 261 | G.h3s5.02 |
Polar | H8 | N | 311 | 8x47 | G.H5 | K | 349 | G.H5.21 |
Polar | TM4 | S | 144 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | S | 144 | 4x38 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | S | 144 | 4x38 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | P | 141 | - | G.HN | E | 28 | G.HN.52 |
Polar | C-term | S | 345 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Polar | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 134 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | F | 139 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | F | 139 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | P | 141 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | P | 141 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM5 | G | 231 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Van-der-waals | TM5 | G | 231 | 5x72 | G.H5 | F | 334 | G.H5.06 |
Hydrophobic | TM7 | L | 310 | 7x56 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | P | 138 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | F | 248 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | F | 139 | - | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | F | 139 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | TM5 | V | 229 | 5x70 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 227 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 227 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | L | 224 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM6 | H | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | H | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | H | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | H | 241 | 6x26 | G.H5 | D | 341 | G.H5.13 |
Ionic | ICL2 | R | 142 | - | G.H5 | D | 350 | G.H5.22 |
Ionic | ICL1 | R | 62 | 12x48 | G.HN | D | 20 | G.HN.44 |
Hydrophobic | C-term | L | 344 | - | G.H3 | W | 258 | G.H3.17 |
Van-der-waals | C-term | L | 344 | - | G.H3 | W | 258 | G.H3.17 |
Hydrophobic | TM5 | P | 230 | 5x71 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM4 | P | 146 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | P | 146 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM5 | P | 230 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | P | 230 | 5x71 | G.H5 | D | 337 | G.H5.09 |
Hydrophobic | TM6 | A | 237 | 6x22 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | A | 237 | 6x22 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | M | 245 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | M | 245 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | R | 240 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM5 | L | 224 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Ionic | TM6 | R | 240 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | R | 240 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | R | 240 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | R | 240 | 6x25 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | C-term | S | 343 | - | G.H3 | W | 258 | G.H3.17 |
Aromatic | ICL2 | F | 139 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | F | 139 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | F | 139 | - | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | TM7 | L | 310 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | L | 310 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | F | 248 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | F | 248 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | F | 358 | - | G.hfs2 | T | 182 | G.hfs2.06 |
Hydrophobic | TM3 | I | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 135 | 3x54 | G.H5 | L | 348 | G.H5.20 |