Gs -
NK3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | L | 274 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM5 | L | 274 | 5x65 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | L | 274 | 5x65 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM6 | Y | 287 | 6x23 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | Y | 287 | 6x23 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM5 | G | 281 | 5x72 | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | TM5 | G | 281 | 5x72 | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | TM6 | M | 300 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | M | 300 | 6x36 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | G | 281 | 5x72 | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | TM5 | G | 281 | 5x72 | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | H8 | F | 363 | 8x50 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | K | 286 | 6x22 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM6 | K | 286 | 6x22 | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | TM6 | K | 286 | 6x22 | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | ICL3 | T | 283 | - | G.S6 | Y | 360 | G.S6.02 |
Polar | TM6 | Q | 290 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | Q | 290 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | Q | 290 | 6x26 | G.H5 | R | 385 | G.H5.17 |
Polar | H8 | N | 360 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | N | 360 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | N | 360 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | R | 396 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | C-term | R | 396 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | R | 396 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Polar | ICL2 | L | 191 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 191 | - | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 191 | - | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | P | 190 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 190 | - | G.H5 | I | 383 | G.H5.15 |
Polar | TM6 | Q | 290 | 6x26 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM5 | P | 280 | 5x71 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM5 | P | 280 | 5x71 | G.H5 | D | 378 | G.H5.10 |
Polar | TM6 | K | 294 | 6x30 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM6 | K | 294 | 6x30 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | R | 183 | 3x50 | G.H5 | L | 393 | G.H5.25 |
Polar | TM6 | Y | 287 | 6x23 | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | TM6 | Y | 287 | 6x23 | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | TM6 | Y | 287 | 6x23 | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | TM5 | P | 280 | 5x71 | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | ICL2 | L | 191 | - | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | ICL2 | P | 190 | - | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 190 | - | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | P | 190 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | P | 190 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | P | 190 | - | G.H5 | H | 387 | G.H5.19 |
Polar | C-term | Q | 397 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | C-term | Q | 397 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | Q | 397 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | TM3 | I | 187 | 3x54 | G.H5 | L | 393 | G.H5.25 |
Polar | H8 | R | 362 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Van-der-waals | H8 | R | 362 | 8x49 | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | ICL2 | L | 191 | - | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 191 | - | G.H5 | I | 383 | G.H5.15 |
Ionic | TM6 | K | 294 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | K | 294 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | K | 294 | 6x30 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | TM6 | V | 297 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM6 | A | 293 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM6 | A | 293 | 6x29 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM3 | R | 183 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 183 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM6 | Y | 287 | 6x23 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | Y | 287 | 6x23 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL1 | M | 116 | 12x50 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | M | 116 | 12x50 | G.H5 | E | 392 | G.H5.24 |
Polar | TM2 | T | 120 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Van-der-waals | TM2 | T | 120 | 2x39 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | P | 190 | - | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | L | 191 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | L | 191 | - | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | TM5 | I | 279 | 5x70 | G.H5 | R | 385 | G.H5.17 |
Polar | TM3 | D | 182 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | D | 182 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | D | 182 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM5 | P | 280 | 5x71 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM5 | P | 280 | 5x71 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | TM6 | V | 297 | 6x33 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM6 | V | 297 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM6 | V | 297 | 6x33 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | I | 187 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 187 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 187 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Ionic | H8 | R | 362 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | H8 | R | 362 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | R | 362 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | R | 362 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Polar | TM5 | D | 282 | 5x73 | G.S6 | H | 362 | G.S6.04 |
Van-der-waals | TM5 | D | 282 | 5x73 | G.S6 | H | 362 | G.S6.04 |
Hydrophobic | ICL2 | L | 191 | - | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | C-term | M | 400 | - | G.HN | L | 30 | G.HN.47 |
Polar | TM5 | D | 282 | 5x73 | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | TM5 | D | 282 | 5x73 | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | TM5 | D | 282 | 5x73 | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | ICL3 | C | 284 | - | G.H4 | L | 346 | G.H4.16 |
Polar | TM5 | D | 282 | 5x73 | G.H4 | Y | 339 | G.H4.08 |
Polar | ICL2 | R | 194 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | R | 194 | - | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | ICL2 | R | 194 | - | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL2 | P | 193 | - | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL3 | C | 284 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | C | 284 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | C | 284 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | TM3 | I | 187 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Van-der-waals | TM3 | I | 187 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Polar | TM2 | N | 121 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM2 | N | 121 | 2x40 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | L | 191 | - | G.S3 | F | 219 | G.S3.03 |
Polar | TM3 | A | 186 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 186 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 186 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM5 | P | 280 | 5x71 | G.H5 | N | 377 | G.H5.09 |
Hydrophobic | TM3 | A | 186 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | C-term | F | 392 | - | G.H3 | R | 280 | G.H3.16 |
Polar | ICL3 | D | 285 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL2 | L | 191 | - | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 191 | - | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | TM6 | M | 301 | 6x37 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM5 | P | 280 | 5x71 | G.H5 | D | 381 | G.H5.13 |
Polar | TM5 | D | 282 | 5x73 | G.S6 | F | 363 | G.S6.05 |
Hydrophobic | TM5 | D | 282 | 5x73 | G.S6 | F | 363 | G.S6.05 |
Van-der-waals | TM5 | D | 282 | 5x73 | G.S6 | F | 363 | G.S6.05 |
Polar | TM5 | D | 282 | 5x73 | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | TM5 | D | 282 | 5x73 | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | TM5 | D | 282 | 5x73 | G.H4 | R | 342 | G.H4.12 |
Hydrophobic | C-term | F | 392 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | C-term | F | 392 | - | G.H3 | W | 281 | G.H3.17 |
Polar | ICL2 | R | 194 | - | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | R | 194 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | R | 194 | - | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | R | 194 | - | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL3 | T | 283 | - | G.S6 | P | 361 | G.S6.03 |
Van-der-waals | ICL3 | T | 283 | - | G.S6 | P | 361 | G.S6.03 |
Hydrophobic | C-term | N | 395 | - | G.H3 | W | 281 | G.H3.17 |
Polar | TM2 | T | 120 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | T | 120 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | T | 120 | 2x39 | G.H5 | Y | 391 | G.H5.23 |