G12 -
BB1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Ionic | TM6 | E | 249 | 6x18 | G.S6 | H | 348 | G.S6.03 |
Polar | TM6 | E | 249 | 6x18 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM6 | E | 249 | 6x18 | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | TM6 | E | 249 | 6x18 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM3 | Q | 123 | 3x32 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | Q | 123 | 3x32 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | TM3 | G | 115 | 3x24 | G.HN | L | 13 | G.HN.13 |
Van-der-waals | TM3 | G | 115 | 3x24 | G.HN | L | 13 | G.HN.13 |
Polar | H8 | S | 328 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | S | 328 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | S | 328 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | V | 121 | 3x30 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | V | 121 | 3x30 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | TM2 | Y | 104 | 2x64 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM2 | Y | 104 | 2x64 | G.HN | V | 4 | G.HN.04 |
Hydrophobic | ICL3 | P | 247 | - | G.H5 | D | 368 | G.H5.13 |
Polar | TM3 | L | 118 | 3x27 | G.HN | L | 13 | G.HN.13 |
Hydrophobic | TM3 | L | 118 | 3x27 | G.HN | L | 13 | G.HN.13 |
Van-der-waals | TM3 | L | 118 | 3x27 | G.HN | L | 13 | G.HN.13 |
Polar | ICL3 | N | 245 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | ICL3 | N | 245 | - | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | ICL3 | N | 245 | - | G.H5 | H | 364 | G.H5.09 |
Polar | TM2 | R | 103 | 2x63 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM2 | R | 103 | 2x63 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM2 | R | 103 | 2x63 | G.HN | L | 8 | G.HN.08 |
Polar | TM3 | V | 146 | 3x55 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | TM3 | V | 146 | 3x55 | G.H5 | K | 367 | G.H5.12 |
Polar | TM2 | R | 103 | 2x63 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM2 | R | 103 | 2x63 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | TM2 | R | 103 | 2x63 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ECL3 | I | 296 | - | G.HN | V | 5 | G.HN.05 |
Van-der-waals | ECL3 | I | 296 | - | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM5 | L | 239 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Polar | TM1 | E | 39 | 1x28 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM1 | E | 39 | 1x28 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | E | 39 | 1x28 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Polar | TM3 | Q | 123 | 3x32 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM3 | Q | 123 | 3x32 | G.HN | R | 10 | G.HN.10 |
Van-der-waals | TM3 | Q | 123 | 3x32 | G.HN | R | 10 | G.HN.10 |
Polar | ECL1 | D | 107 | - | G.HN | G | 3 | G.HN.03 |
Hydrophobic | ECL1 | D | 107 | - | G.HN | G | 3 | G.HN.03 |
Hydrophobic | ECL2 | A | 197 | - | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL2 | A | 197 | - | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM2 | V | 99 | 2x59 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | TM2 | V | 99 | 2x59 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | ICL2 | M | 149 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | M | 149 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | S | 242 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM5 | S | 242 | 5x68 | G.H5 | L | 371 | G.H5.16 |
Polar | TM3 | A | 144 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 144 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 144 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Polar | TM6 | Q | 257 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM6 | Q | 257 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | Q | 257 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL2 | M | 149 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Polar | TM3 | I | 119 | 3x28 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM3 | I | 119 | 3x28 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | TM3 | I | 119 | 3x28 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM1 | F | 68 | 1x57 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM1 | F | 68 | 1x57 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | L | 118 | 3x27 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | L | 118 | 3x27 | G.HN | L | 12 | G.HN.12 |
Polar | TM5 | S | 242 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | S | 242 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM1 | G | 35 | 1x24 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM1 | G | 35 | 1x24 | G.HN | M | 1 | G.HN.01 |
Polar | TM3 | Q | 123 | 3x32 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM3 | Q | 123 | 3x32 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM3 | Q | 123 | 3x32 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM3 | L | 124 | 3x33 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | L | 124 | 3x33 | G.HN | L | 12 | G.HN.12 |
Polar | TM2 | V | 99 | 2x59 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM2 | V | 99 | 2x59 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM2 | V | 99 | 2x59 | G.HN | S | 9 | G.HN.09 |
Polar | TM6 | R | 289 | 6x58 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM6 | R | 289 | 6x58 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | TM6 | R | 289 | 6x58 | G.HN | V | 5 | G.HN.05 |
Polar | TM3 | I | 119 | 3x28 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | TM3 | I | 119 | 3x28 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | I | 119 | 3x28 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | M | 151 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | M | 151 | 34x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ECL2 | I | 187 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ICL3 | P | 247 | - | G.H5 | A | 365 | G.H5.10 |
Hydrophobic | TM6 | L | 264 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | L | 264 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL3 | P | 247 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | TM7 | M | 303 | 7x31 | G.HN | V | 4 | G.HN.04 |
Polar | TM2 | C | 96 | 2x56 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM2 | C | 96 | 2x56 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | TM2 | C | 96 | 2x56 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Polar | ICL2 | S | 154 | 34x56 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL2 | S | 154 | 34x56 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | S | 154 | 34x56 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM3 | I | 119 | 3x28 | G.HN | R | 10 | G.HN.10 |
Van-der-waals | TM3 | I | 119 | 3x28 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM2 | P | 78 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Polar | TM2 | D | 100 | 2x60 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM2 | D | 100 | 2x60 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | TM2 | D | 100 | 2x60 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM6 | Y | 286 | 6x55 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM6 | Y | 286 | 6x55 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | ICL2 | M | 149 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | M | 149 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Polar | H8 | E | 329 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Polar | H8 | S | 330 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | S | 330 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 330 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Polar | ICL2 | S | 154 | 34x56 | G.HN | A | 48 | G.HN.48 |
Van-der-waals | ICL2 | S | 154 | 34x56 | G.HN | A | 48 | G.HN.48 |
Hydrophobic | ICL2 | G | 155 | 34x57 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL2 | G | 155 | 34x57 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | ECL3 | P | 298 | - | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM6 | R | 261 | 6x30 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | ICL2 | M | 151 | 34x53 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | M | 151 | 34x53 | G.hns1 | R | 56 | G.hns1.03 |
Polar | TM6 | R | 261 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 261 | 6x30 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ICL3 | G | 248 | - | G.S6 | L | 346 | G.S6.01 |
Van-der-waals | ICL3 | G | 248 | - | G.S6 | L | 346 | G.S6.01 |
Ionic | TM4 | E | 178 | 4x61 | G.HN | R | 10 | G.HN.10 |
Polar | TM4 | E | 178 | 4x61 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM4 | E | 178 | 4x61 | G.HN | R | 10 | G.HN.10 |
Van-der-waals | TM4 | E | 178 | 4x61 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | ICL2 | M | 149 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | M | 149 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | TM3 | P | 120 | 3x29 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | P | 120 | 3x29 | G.HN | L | 12 | G.HN.12 |
Polar | ECL1 | D | 107 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | ECL1 | D | 107 | - | G.HN | M | 1 | G.HN.01 |
Polar | ICL2 | P | 148 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL3 | P | 247 | - | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | ICL3 | P | 247 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | ICL2 | M | 149 | 34x51 | G.S3 | F | 223 | G.S3.03 |
Hydrophobic | ECL2 | P | 200 | 45x52 | G.HN | R | 10 | G.HN.10 |
Van-der-waals | ECL2 | P | 200 | 45x52 | G.HN | R | 10 | G.HN.10 |
Polar | TM2 | T | 95 | 2x551 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM2 | T | 95 | 2x551 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | TM2 | T | 95 | 2x551 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM3 | I | 122 | 3x31 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM3 | I | 122 | 3x31 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | TM3 | P | 120 | 3x29 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM6 | T | 260 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 260 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Polar | ECL3 | Y | 293 | - | G.HN | R | 6 | G.HN.06 |
Aromatic | ECL3 | Y | 293 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ECL3 | Y | 293 | - | G.HN | R | 6 | G.HN.06 |
Van-der-waals | ECL3 | Y | 293 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ICL2 | T | 153 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Van-der-waals | ICL2 | T | 153 | 34x55 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM2 | T | 95 | 2x551 | G.HN | L | 12 | G.HN.12 |
Van-der-waals | TM2 | T | 95 | 2x551 | G.HN | L | 12 | G.HN.12 |
Hydrophobic | TM3 | I | 119 | 3x28 | G.HN | L | 13 | G.HN.13 |
Van-der-waals | TM3 | I | 119 | 3x28 | G.HN | L | 13 | G.HN.13 |
Hydrophobic | ICL2 | Q | 152 | 34x54 | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ECL2 | F | 195 | - | G.HN | G | 3 | G.HN.03 |
Hydrophobic | TM2 | V | 99 | 2x59 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM2 | N | 79 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | N | 79 | 2x40 | G.H5 | L | 380 | G.H5.25 |
Polar | TM5 | H | 212 | 5x39 | G.HN | R | 10 | G.HN.10 |
Van-der-waals | TM5 | H | 212 | 5x39 | G.HN | R | 10 | G.HN.10 |
Hydrophobic | ICL3 | L | 246 | - | G.H5 | D | 368 | G.H5.13 |
Polar | TM2 | D | 100 | 2x60 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM2 | D | 100 | 2x60 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL3 | I | 296 | - | G.HN | R | 6 | G.HN.06 |
Van-der-waals | ECL3 | I | 296 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ICL2 | S | 154 | 34x56 | G.HN | R | 51 | G.HN.51 |
Van-der-waals | ICL2 | S | 154 | 34x56 | G.HN | R | 51 | G.HN.51 |
Hydrophobic | TM3 | V | 114 | 3x23 | G.HN | L | 13 | G.HN.13 |
Van-der-waals | TM3 | V | 114 | 3x23 | G.HN | L | 13 | G.HN.13 |
Polar | TM3 | Q | 123 | 3x32 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM3 | Q | 123 | 3x32 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | TM3 | Q | 123 | 3x32 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM6 | L | 264 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | TM7 | H | 302 | 7x30 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM6 | E | 249 | 6x18 | G.H4 | V | 332 | G.H4.12 |
Van-der-waals | TM6 | E | 249 | 6x18 | G.H4 | V | 332 | G.H4.12 |
Ionic | TM6 | R | 261 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 261 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | R | 261 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | R | 261 | 6x30 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | E | 249 | 6x18 | G.S6 | L | 346 | G.S6.01 |
Polar | TM2 | R | 103 | 2x63 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM2 | R | 103 | 2x63 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM2 | R | 103 | 2x63 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ICL3 | G | 248 | - | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM4 | L | 158 | 4x40 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM4 | L | 158 | 4x40 | G.HN | R | 52 | G.HN.52 |
Polar | H8 | S | 328 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | S | 328 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 328 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Polar | TM7 | R | 310 | 7x38 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | TM7 | R | 310 | 7x38 | G.HN | S | 9 | G.HN.09 |
Polar | TM6 | H | 253 | 6x22 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | TM6 | H | 253 | 6x22 | G.h4s6 | S | 343 | G.h4s6.12 |
Van-der-waals | TM6 | H | 253 | 6x22 | G.h4s6 | S | 343 | G.h4s6.12 |
Hydrophobic | ICL2 | M | 149 | 34x51 | G.H5 | K | 367 | G.H5.12 |