Gi2 - BB1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 E 249 6x18 G.S6 T 322 G.S6.03
Hydrophobic TM6 E 249 6x18 G.S6 T 322 G.S6.03
Van-der-waals TM6 E 249 6x18 G.S6 T 322 G.S6.03
Hydrophobic TM2 P 78 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 P 78 2x39 G.H5 C 352 G.H5.23
Polar TM6 Q 257 6x26 G.H5 D 342 G.H5.13
Hydrophobic ICL3 L 246 - G.H5 D 342 G.H5.13
Hydrophobic TM3 I 145 3x54 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 148 34x50 G.H5 T 341 G.H5.12
Hydrophobic ICL2 M 149 34x51 G.H5 I 344 G.H5.15
Polar TM6 E 249 6x18 G.S6 F 324 G.S6.05
Hydrophobic TM6 E 249 6x18 G.S6 F 324 G.S6.05
Van-der-waals TM6 E 249 6x18 G.S6 F 324 G.S6.05
Polar H8 S 328 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 S 328 8x47 G.H5 G 353 G.H5.24
Hydrophobic ICL2 M 149 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 M 149 34x51 G.S3 L 195 G.S3.01
Polar TM6 H 253 6x22 G.h4s6 K 315 G.h4s6.08
Hydrophobic TM6 H 253 6x22 G.h4s6 K 315 G.h4s6.08
Van-der-waals TM6 H 253 6x22 G.h4s6 K 315 G.h4s6.08
Hydrophobic H8 S 328 8x47 G.H5 F 355 G.H5.26
Van-der-waals H8 S 328 8x47 G.H5 F 355 G.H5.26
Hydrophobic TM3 I 145 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 349 G.H5.20
Hydrophobic ICL3 P 247 - G.H5 D 342 G.H5.13
Hydrophobic ICL2 S 154 34x56 G.HN R 24 G.HN.48
Van-der-waals ICL2 S 154 34x56 G.HN R 24 G.HN.48
Hydrophobic ICL2 Q 152 34x54 G.hns1 A 31 G.hns1.02
Ionic TM6 K 256 6x25 G.h4s6 D 316 G.h4s6.09
Polar TM6 K 256 6x25 G.h4s6 D 316 G.h4s6.09
Van-der-waals TM6 K 256 6x25 G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 V 268 6x37 G.H5 L 354 G.H5.25
Polar TM3 R 141 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 R 141 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 141 3x50 G.H5 C 352 G.H5.23
Hydrophobic ICL3 G 248 - G.S6 T 322 G.S6.03
Van-der-waals ICL3 G 248 - G.S6 T 322 G.S6.03
Polar TM3 A 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 A 144 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 A 144 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 T 153 34x55 G.HN R 24 G.HN.48
Polar H8 E 329 8x48 G.H5 F 355 G.H5.26
Hydrophobic H8 E 329 8x48 G.H5 F 355 G.H5.26
Van-der-waals H8 E 329 8x48 G.H5 F 355 G.H5.26
Hydrophobic ICL2 M 151 34x53 G.H5 I 344 G.H5.15
Ionic TM6 R 261 6x30 G.H5 D 342 G.H5.13
Polar TM6 R 261 6x30 G.H5 D 342 G.H5.13
Hydrophobic TM6 R 261 6x30 G.H5 D 342 G.H5.13
Van-der-waals TM6 R 261 6x30 G.H5 D 342 G.H5.13
Hydrophobic TM3 R 141 3x50 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 264 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 264 6x33 G.H5 L 354 G.H5.25
Polar TM2 S 76 2x37 G.H5 D 351 G.H5.22
Van-der-waals TM7 L 327 7x56 G.H5 G 353 G.H5.24
Hydrophobic ICL2 T 153 34x55 G.HN E 28 G.HN.52
Van-der-waals ICL2 T 153 34x55 G.HN E 28 G.HN.52
Van-der-waals TM6 N 251 6x20 G.H4 Q 305 G.H4.12
Polar TM7 L 327 7x56 G.H5 F 355 G.H5.26
Hydrophobic TM7 L 327 7x56 G.H5 F 355 G.H5.26
Van-der-waals TM7 L 327 7x56 G.H5 F 355 G.H5.26
Polar ICL2 P 148 34x50 G.H5 N 348 G.H5.19
Hydrophobic TM6 E 249 6x18 G.S6 H 323 G.S6.04
Ionic ICL2 D 150 34x52 G.hns1 R 32 G.hns1.03
Polar ICL2 D 150 34x52 G.hns1 R 32 G.hns1.03
Polar TM6 N 251 6x20 G.H4 E 309 G.H4.16
Hydrophobic TM6 N 251 6x20 G.H4 E 309 G.H4.16
Van-der-waals TM6 N 251 6x20 G.H4 E 309 G.H4.16
Hydrophobic ICL3 P 247 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 P 247 - G.S6 Y 321 G.S6.02
Polar ICL2 M 149 34x51 G.hns1 R 32 G.hns1.03
Hydrophobic ICL3 P 247 - G.S6 H 323 G.S6.04
Hydrophobic TM6 H 253 6x22 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM2 P 78 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 P 78 2x39 G.H5 D 351 G.H5.22
Hydrophobic ICL2 M 151 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 M 151 34x53 G.hns1 A 31 G.hns1.02
Polar C-term Y 353 - G.H3 K 258 G.H3.16
Hydrophobic ICL3 P 247 - G.H5 D 338 G.H5.09
Van-der-waals ICL3 P 247 - G.H5 D 338 G.H5.09
Hydrophobic TM7 L 327 7x56 G.H5 L 354 G.H5.25
Van-der-waals TM7 L 327 7x56 G.H5 L 354 G.H5.25
Polar TM6 Q 257 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 Q 257 6x26 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 Q 257 6x26 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 P 148 34x50 G.H5 I 345 G.H5.16
Hydrophobic ICL3 P 247 - G.H5 A 339 G.H5.10
Van-der-waals ICL3 P 247 - G.H5 A 339 G.H5.10
Polar ICL3 G 248 - G.S6 H 323 G.S6.04
Hydrophobic ICL3 G 248 - G.S6 H 323 G.S6.04
Van-der-waals ICL3 G 248 - G.S6 H 323 G.S6.04
Hydrophobic ICL2 M 149 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 M 149 34x51 G.H5 F 337 G.H5.08
Hydrophobic ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Van-der-waals ICL2 P 148 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 L 239 5x65 G.H5 L 349 G.H5.20
Hydrophobic ICL2 M 149 34x51 G.H5 T 341 G.H5.12
Van-der-waals ICL2 M 149 34x51 G.H5 T 341 G.H5.12
Polar TM5 S 242 5x68 G.H5 D 342 G.H5.13
Polar ICL2 S 154 34x56 G.HN L 23 G.HN.47
Hydrophobic ICL2 S 154 34x56 G.HN L 23 G.HN.47
Hydrophobic TM3 A 144 3x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 S 154 34x56 G.HN G 27 G.HN.51
Hydrophobic TM6 E 249 6x18 G.H4 Q 305 G.H4.12
Van-der-waals TM6 E 249 6x18 G.H4 Q 305 G.H4.12