Gz - NPBW1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 83.9

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 R 134 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 134 3x50 G.H5 L 354 G.H5.25
Polar ICL2 T 141 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 T 141 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 T 141 - G.H5 N 348 G.H5.19
Ionic TM6 R 244 6x28 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM3 V 138 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 138 3x54 G.H5 L 349 G.H5.20
Polar TM3 R 134 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM3 R 134 3x50 G.H5 I 352 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 I 352 G.H5.23
Hydrophobic TM6 V 249 6x33 G.H5 C 355 G.H5.26
Van-der-waals TM6 V 249 6x33 G.H5 C 355 G.H5.26
Hydrophobic TM6 A 241 6x25 G.S6 Y 321 G.S6.02
Van-der-waals TM6 A 241 6x25 G.S6 Y 321 G.S6.02
Hydrophobic TM6 L 252 6x36 G.H5 G 353 G.H5.24
Van-der-waals TM6 L 252 6x36 G.H5 G 353 G.H5.24
Hydrophobic ICL2 R 145 - G.S3 L 195 G.S3.01
Hydrophobic TM3 V 138 3x54 G.H5 I 352 G.H5.23
Polar ICL2 R 146 - G.hns1 R 31 G.hns1.02
Hydrophobic ICL2 R 146 - G.hns1 R 31 G.hns1.02
Van-der-waals ICL2 R 146 - G.hns1 R 31 G.hns1.02
Polar ICL3 D 236 - G.H5 D 342 G.H5.13
Polar ICL2 R 146 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 R 146 - G.HN Q 28 G.HN.52
Van-der-waals ICL2 R 146 - G.HN Q 28 G.HN.52
Hydrophobic ICL2 R 150 - G.H5 I 352 G.H5.23
Hydrophobic TM6 L 242 6x26 G.H5 Q 346 G.H5.17
Polar ICL2 S 144 - G.S3 L 195 G.S3.01
Hydrophobic ICL2 S 144 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 S 144 - G.S3 L 195 G.S3.01
Hydrophobic TM6 A 241 6x25 G.H5 Q 346 G.H5.17
Hydrophobic TM6 V 249 6x33 G.H5 L 349 G.H5.20
Ionic ICL2 R 145 - G.s2s3 E 194 G.s2s3.02
Polar ICL2 R 145 - G.s2s3 E 194 G.s2s3.02
Hydrophobic ICL2 R 145 - G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 R 145 - G.s2s3 E 194 G.s2s3.02
Hydrophobic TM3 V 137 3x53 G.H5 I 352 G.H5.23
Van-der-waals TM3 V 137 3x53 G.H5 I 352 G.H5.23
Hydrophobic TM4 T 151 4x38 G.HN Q 28 G.HN.52
Van-der-waals TM4 T 151 4x38 G.HN Q 28 G.HN.52
Hydrophobic TM6 A 245 6x29 G.H5 Q 346 G.H5.17
Hydrophobic TM3 V 137 3x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 T 141 - G.H5 I 345 G.H5.16
Van-der-waals ICL2 T 141 - G.H5 I 345 G.H5.16
Hydrophobic TM6 V 253 6x37 G.H5 L 354 G.H5.25
Polar H8 R 316 8x52 G.h3s5 N 262 G.h3s5.02
Van-der-waals H8 R 316 8x52 G.h3s5 N 262 G.h3s5.02
Polar TM6 A 245 6x29 G.H5 C 355 G.H5.26
Hydrophobic TM6 A 245 6x29 G.H5 C 355 G.H5.26
Hydrophobic ICL3 H 238 - G.H5 F 335 G.H5.06
Hydrophobic ICL2 S 144 - G.s2s3 K 193 G.s2s3.01
Van-der-waals ICL2 S 144 - G.s2s3 K 193 G.s2s3.01
Hydrophobic TM6 L 252 6x36 G.H5 L 354 G.H5.25
Hydrophobic TM6 L 242 6x26 G.H5 I 345 G.H5.16
Hydrophobic ICL3 L 235 - G.H5 I 345 G.H5.16
Van-der-waals ICL3 L 235 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 R 150 - G.H5 Y 351 G.H5.22
Van-der-waals ICL2 R 150 - G.H5 Y 351 G.H5.22
Hydrophobic TM6 R 248 6x32 G.H5 C 355 G.H5.26
Van-der-waals TM6 R 248 6x32 G.H5 C 355 G.H5.26
Hydrophobic ICL2 S 144 - G.s2s3 E 194 G.s2s3.02
Van-der-waals ICL2 S 144 - G.s2s3 E 194 G.s2s3.02
Polar TM3 R 134 3x50 G.H5 G 353 G.H5.24
Van-der-waals TM3 R 134 3x50 G.H5 G 353 G.H5.24
Hydrophobic TM5 L 230 5x65 G.H5 L 349 G.H5.20
Hydrophobic TM5 M 233 5x68 G.H5 I 345 G.H5.16
Van-der-waals TM5 M 233 5x68 G.H5 I 345 G.H5.16
Hydrophobic TM2 T 70 2x37 G.H5 Y 351 G.H5.22
Hydrophobic TM2 T 72 2x39 G.H5 I 352 G.H5.23
Hydrophobic TM5 L 226 5x61 G.H5 L 354 G.H5.25
Hydrophobic ICL3 L 235 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 L 235 - G.H5 D 342 G.H5.13
Hydrophobic TM6 A 241 6x25 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 A 241 6x25 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 242 6x26 G.H5 D 342 G.H5.13
Van-der-waals TM6 L 242 6x26 G.H5 D 342 G.H5.13
Hydrophobic ICL3 D 236 - G.H5 F 335 G.H5.06
Van-der-waals ICL3 D 236 - G.H5 F 335 G.H5.06
Polar TM2 T 72 2x39 G.H5 Y 351 G.H5.22
Polar TM6 V 249 6x33 G.H5 L 354 G.H5.25
Hydrophobic TM6 V 249 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 V 249 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 R 146 - G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 146 - G.hns1 R 32 G.hns1.03